Cancer Research AACR Conference on Molecular Diagnostics - 2008 AACR Conference on Molecular Diagnostics - 2008
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[Cancer Research 60, 4682-4688, September 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Increased Expression of H/T-Cadherin in Tumor-penetrating Blood Vessels1

Lorenza Wyder2,3, Alessandra Vitaliti2,4, Henriette Schneider, Lionel W. Hebbard, Dirk R. Moritz5, Mariana Wittmer, Malek Ajmo and Roman Klemenz6

Division of Cancer Research, Department of Pathology, University Hospital, CH-8091 Zurich, Switzerland

Neovascularization is a prerequisite for tumor growth. Thus, selective destruction of the tumor vasculature should prevent tumor expansion. We have established a method to identify proteins that are specifically expressed on the surface of endothelial cells in tumors. CD31-positive endothelial cells were isolated from Lewis lung carcinoma lung metastases as well as from normal lung tissue. cDNAs derived from these cells were subjected to a subtractive hybridization procedure, and cDNAs overrepresented in tumor-derived endothelial cells were isolated; those encoding surface proteins were selected using a signal sequence trap assay. One isolated cDNA encoded H/T-cadherin. In this report, we show that mouse H/T-cadherin is overexpressed on endothelial cells of several tumors, whereas it is expressed only on a subset of endothelial cells in healthy organs. On the basis of the expression of H/T-cadherin in lung metastases of different tumors, we suggest that different tumors can have a differential influence on the expression of endothelial cell surface proteins.




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