Cancer Research Meeting Calendar Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haruki, N.
Right arrow Articles by Takahashi, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haruki, N.
Right arrow Articles by Takahashi, T.
[Cancer Research 60, 4689-4692, September 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Histological Type-selective, Tumor-predominant Expression of a Novel CHK1 Isoform and Infrequent in Vivo Somatic CHK2 Mutation in Small Cell Lung Cancer1

Nobuhiro Haruki, Hiroko Saito, Yoshio Tatematsu, Hiroyuki Konishi, Tomoko Harano, Akira Masuda, Hirotaka Osada, Yoshitaka Fujii and Takashi Takahashi2

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan [N. H., H. S., Y. T., H. K., T. H., A. M., H. O., T. T.], and Department of Surgery II, Nagoya City University Medical School, Nagoya 467-8601, Japan [N. H., Y. F.]

Inactivation of p53, which represents the most prevalent genetic alteration in lung cancer, has been shown to play a crucial role in the acquisition of genomic instability. We examined 44 lung cancer specimens to search for mutations in the CHK1 and CHK2 genes, which have been suggested to play roles in regulating p53 after DNA damage. We found that the CHK2 gene was somatically mutated in lung cancer in vivo, although at a low frequency, and that a previously undescribed shorter isoform of CHK1 was expressed preferentially in small cell lung cancer in a tumor-predominant manner. Additional studies are warranted to investigate the functional significance of these changes as well as the potential involvement of other components in this important pathway to maintain genomic stability.




This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
S. A. Martin and T. Ouchi
Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN
Mol. Cancer Ther., August 1, 2008; 7(8): 2509 - 2516.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. M. Kass, J. Ahn, T. Tanaka, W. A. Freed-Pastor, S. Keezer, and C. Prives
Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456
J. Biol. Chem., October 12, 2007; 282(41): 30311 - 30321.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. H. Williams, D. Choong, S. A. Johnson, and I. G. Campbell
Genetic and Epigenetic Analysis of CHEK2 in Sporadic Breast, Colon, and Ovarian Cancers
Clin. Cancer Res., December 1, 2006; 12(23): 6967 - 6972.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
V. Cordon-Preciado, S. Ufano, and A. Bueno
Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damage
Nucleic Acids Res., November 6, 2006; 34(20): 5852 - 5862.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. L. Gibson, R. S. Bindra, and P. M. Glazer
Hypoxia-Induced Phosphorylation of Chk2 in an Ataxia Telangiectasia Mutated-Dependent Manner
Cancer Res., December 1, 2005; 65(23): 10734 - 10741.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Jurvansuu, K. Raj, A. Stasiak, and P. Beard
Viral Transport of DNA Damage That Mimics a Stalled Replication Fork
J. Virol., January 1, 2005; 79(1): 569 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. S. Kim, L. Cao, C. Li, X. Xu, L. J. Huber, L. A. Chodosh, and C.-X. Deng
Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1
Mol. Cell. Biol., November 1, 2004; 24(21): 9498 - 9507.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Tort, S. Hernandez, S. Bea, A. Martinez, M. Esteller, J. G. Herman, X. Puig, E. Camacho, M. Sanchez, I. Nayach, et al.
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
Blood, December 15, 2002; 100(13): 4602 - 4608.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. Shibata, N. Haruki, Y. Kuwabara, H. Ishiguro, N. Shinoda, A. Sato, M. Kimura, H. Koyama, T. Toyama, T. Nishiwaki, et al.
Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer
Carcinogenesis, October 1, 2002; 23(10): 1695 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
X. Xu, L. M. Tsvetkov, and D. F. Stern
Chk2 Activation and Phosphorylation-Dependent Oligomerization
Mol. Cell. Biol., June 15, 2002; 22(12): 4419 - 4432.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-Y. Ahn, X. Li, H. L. Davis, and C. E. Canman
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
J. Biol. Chem., May 24, 2002; 277(22): 19389 - 19395.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Hangaishi, S. Ogawa, Y. Qiao, L. Wang, N. Hosoya, K. Yuji, Y. Imai, K. Takeuchi, S. Miyawaki, and H. Hirai
Mutations of Chk2 in primary hematopoietic neoplasms
Blood, April 15, 2002; 99(8): 3075 - 3077.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Konishi, T. Nakagawa, T. Harano, K. Mizuno, H. Saito, A. Masuda, H. Matsuda, H. Osada, and T. Takahashi
Identification of Frequent G2 Checkpoint Impairment and a Homozygous Deletion of 14-3-3{epsilon} at 17p13.3 in Small Cell Lung Cancers
Cancer Res., January 1, 2002; 62(1): 271 - 276.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. Zheng, L. Li, H. Shen, E. M. Sturgis, S. A. Eicher, S. S. Strom, M. R. Spitz, and Q. Wei
Polymorphic hCHK2/hCds1 codon 84 allele and risk of squamous cell carcinoma of the head and neck--a case-control analysis
Carcinogenesis, December 1, 2001; 22(12): 2005 - 2008.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. B. Lee, S. H. Kim, D. W. Bell, D. C. R. Wahrer, T. A. Schiripo, M. M. Jorczak, D. C. Sgroi, J. E. Garber, F. P. Li, K. E. Nichols, et al.
Destabilization of CHK2 by a Missense Mutation Associated with Li-Fraumeni Syndrome
Cancer Res., November 1, 2001; 61(22): 8062 - 8067.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Vahteristo, A. Tamminen, P. Karvinen, H. Eerola, C. Eklund, L. A. Aaltonen, C. Blomqvist, K. Aittomaki, and H. Nevanlinna
p53, CHK2, and CHK1 Genes in Finnish Families with Li-Fraumeni Syndrome: Further Evidence of CHK2 in Inherited Cancer Predisposition
Cancer Res., August 1, 2001; 61(15): 5718 - 5722.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Lukas, J. Bartkova, L. Latella, J. Falck, N. Mailand, T. Schroeder, M. Sehested, J. Lukas, and J. Bartek
DNA Damage-activated Kinase Chk2 Is Independent of Proliferation or Differentiation Yet Correlates with Tissue Biology
Cancer Res., July 1, 2001; 61(13): 4990 - 4993.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Matsuoka, T. Nakagawa, A. Masuda, N. Haruki, S. J. Elledge, and T. Takahashi
Reduced Expression and Impaired Kinase Activity of a Chk2 Mutant Identified in Human Lung Cancer
Cancer Res., July 1, 2001; 61(14): 5362 - 5365.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.