Overexpression of Hypoxia-inducible Factor 1{{alpha}} Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer

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Overexpression of Hypoxia-inducible Factor 1 ${alpha}$ Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer¹

Peter Birner², Monika Schindl, Andreas Obermair, Christina Plank, Gerhard Breitenecker and Georg Oberhuber

Institute of Clinical Pathology [P. B., C. P., G. B., G. O.] and Department of Gynecology and Obstetrics [M. S., A. O.], University of Vienna, A-1090 Vienna, Austria

Hypoxia-inducible factor 1 ${alpha}$ (HIF-1 ${alpha}$ ) is a transcriptional factor thatregulates genes involved in response to hypoxia and promotes neoangiogenesis,which are considered essential for tumor growth and progression.Using immunohistochemistry, we investigated the influence ofHIF-1 ${alpha}$ expression on prognosis in 91 patients with cervical cancer stagepT1b. In univariate and multivariate analysis, patients with strongexpression of HIF-1 ${alpha}$ had a significantly shorter overall survivaltime (P = 0.0307, log-rank test) and disease-free survival time(P < 0.0001, log-rank test) compared with those with moderateto absent HIF-1 ${alpha}$ expression. HIF-1 ${alpha}$ expression is a strong independent prognosticmarker in early stage cervical cancer.

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