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Is a Marker for an Unfavorable Prognosis in Early-Stage Invasive Cervical Cancer1
Institute of Clinical Pathology [P. B., C. P., G. B., G. O.] and Department of Gynecology and Obstetrics [M. S., A. O.], University of Vienna, A-1090 Vienna, Austria
Hypoxia-inducible factor 1
(HIF-1) is a transcriptional factor
that regulates genes involved in response to hypoxia and promotes
neoangiogenesis, which are considered essential for tumor growth and
progression. Using immunohistochemistry, we investigated the influence
of HIF-1 expression on prognosis in 91 patients with cervical cancer
stage pT1b. In univariate and multivariate analysis, patients with
strong expression of HIF-1 had a significantly shorter overall
survival time (P = 0.0307, log-rank test)
and disease-free survival time (P < 0.0001, log-rank test) compared with those with moderate to absent
HIF-1 expression. HIF-1 expression is a strong independent
prognostic marker in early stage cervical cancer.
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T. K.-W. Lee, K. Man, M.-T. Ling, X.-H. Wang, Y.-C. Wong, C.-M. Lo, R. T.-P. Poon, I. O.-L. Ng, and S.-T. Fan Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway Carcinogenesis, November 1, 2003; 24(11): 1729 - 1736. [Abstract] [Full Text] [PDF]
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E.-J. Yeo, Y.-S. Chun, Y.-S. Cho, J. Kim, J.-C. Lee, M.-S. Kim, and J.-W. Park YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor 1 J Natl Cancer Inst, April 2, 2003; 95(7): 516 - 525. [Abstract] [Full Text] [PDF]
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M. Schindl, S. F. Schoppmann, T. Strobel, H. Heinzl, C. Leisser, R. Horvat, and P. Birner Level of Id-1 Protein Expression Correlates with Poor Differentiation, Enhanced Malignant Potential, and More Aggressive Clinical Behavior of Epithelial Ovarian Tumors Clin. Cancer Res., February 1, 2003; 9(2): 779 - 785. [Abstract] [Full Text] [PDF]
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S. J. Welsh, W. T. Bellamy, M. M. Briehl, and G. Powis The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1{alpha} Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis Cancer Res., September 1, 2002; 62(17): 5089 - 5095. [Abstract] [Full Text] [PDF]
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J. S. Isaacs, Y.-J. Jung, E. G. Mimnaugh, A. Martinez, F. Cuttitta, and L. M. Neckers Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1alpha -degradative Pathway J. Biol. Chem., August 9, 2002; 277(33): 29936 - 29944. [Abstract] [Full Text] [PDF]
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H. Lu, R. A. Forbes, and A. Verma Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis J. Biol. Chem., June 21, 2002; 277(26): 23111 - 23115. [Abstract] [Full Text] [PDF]
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M. S. Wiesener, P. M. Munchenhagen, I. Berger, N. V. Morgan, J. Roigas, A. Schwiertz, J. S. Jurgensen, G. Gruber, P. H. Maxwell, S. A. Loning, et al. Constitutive Activation of Hypoxia-inducible Genes Related to Overexpression of Hypoxia-inducible Factor-1{{alpha}} in Clear Cell Renal Carcinomas Cancer Res., July 1, 2001; 61(13): 5215 - 5222. [Abstract] [Full Text] [PDF]
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P. Birner, M. Schindl, A. Obermair, G. Breitenecker, and G. Oberhuber Expression of Hypoxia-inducible Factor 1{{alpha}} in Epithelial Ovarian Tumors: Its Impact on Prognosis and on Response to Chemotherapy Clin. Cancer Res., June 1, 2001; 7(6): 1661 - 1668. [Abstract] [Full Text] [PDF]
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M. I. Koukourakis, A. Giatromanolaki, J. Skarlatos, L. Corti, S. Blandamura, M. Piazza, K. C. Gatter, and A. L. Harris Hypoxia Inducible Factor (HIF-1a and HIF-2a) Expression in Early Esophageal Cancer and Response to Photodynamic Therapy and Radiotherapy Cancer Res., March 1, 2001; 61(5): 1830 - 1832. [Abstract] [Full Text]
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R. Bos, H. Zhong, C. F. Hanrahan, E. C. M. Mommers, G. L. Semenza, H. M. Pinedo, M. D. Abeloff, J. W. Simons, P. J. van Diest, and E. van der Wall Levels of Hypoxia-Inducible Factor-1{{alpha}} During Breast Carcinogenesis J Natl Cancer Inst, February 21, 2001; 93(4): 309 - 314. [Abstract] [Full Text] [PDF] |
