Cancer Research AACR Conference on Molecular Diagnostics - 2008 Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chulada, P. C.
Right arrow Articles by Langenbach, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chulada, P. C.
Right arrow Articles by Langenbach, R.
[Cancer Research 60, 4705-4708, September 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Genetic Disruption of Ptgs-1, as well as of Ptgs-2, Reduces Intestinal Tumorigenesis in Min Mice

Patricia C. Chulada1, Morrow B. Thompson, Joel F. Mahler, Christine M. Doyle, Beth W. Gaul, Christopher Lee, Howard F. Tiano, Scott G. Morham, Oliver Smithies and Robert Langenbach1

Laboratory of Experimental Carcinogenesis and Mutagenesis [P. C. C., M. B. T., C. L., H. F. T., C. D. L., R. L.], Laboratory of Experimental Pathology [J. F. M.], NIH, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Experimental Pathology Laboratories, Research Triangle Park, North Carolina 27709 [C. M. D., B. W. G.]; and Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 [S. G. M., O. S.]

Two isoforms of cyclooxygenase (COX) are known, and to date most studies have implicated COX-2, rather than COX-1, as the isoform involved in colon carcinogenesis. In the present study, we show that homologous disruption of either Ptgs-1 or Ptgs-2 (genes coding for COX-1 or COX-2, respectively) reduced polyp formation in Min/+ mice by ~80%. Only COX-1 protein was immunohistochemically detected in normal intestinal tissue, whereas both COX-1 and variable levels of COX-2 protein were detected in polyps. Prostaglandin E2 was increased in polyps compared with normal tissue, and both COX-1 and COX-2 contributed to the PGE2 produced. The results indicate that COX-1, as well as COX-2, plays a key role in intestinal tumorigenesis and that COX-1 may also be a chemotherapeutic target for nonsteroidal anti-inflammatory drugs.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
M. Nakanishi, D. C. Montrose, P. Clark, P. R. Nambiar, G. S. Belinsky, K. P. Claffey, D. Xu, and D. W. Rosenberg
Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis
Cancer Res., May 1, 2008; 68(9): 3251 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Blanc, J. O. Henderson, R. D. Newberry, Y. Xie, S.-J. Cho, E. P. Newberry, S. Kennedy, D. C. Rubin, H. L. Wang, J. Luo, et al.
Deletion of the AU-Rich RNA Binding Protein Apobec-1 Reduces Intestinal Tumor Burden in Apcmin Mice
Cancer Res., September 15, 2007; 67(18): 8565 - 8573.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Rakoff-Nahoum and R. Medzhitov
Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88
Science, July 6, 2007; 317(5834): 124 - 127.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. T. Chan, S. Ogino, and C. S. Fuchs
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of COX-2
N. Engl. J. Med., May 24, 2007; 356(21): 2131 - 2142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W.-L. Yang, K. Q. Cai, J. L. Smedberg, E. R. Smith, A. Klein-Szanto, T. C. Hamilton, and X.-X. Xu
A Reduction of Cyclooxygenase 2 Gene Dosage Counters the Ovarian Morphological Aging and Tumor Phenotype in Wv Mice
Am. J. Pathol., April 1, 2007; 170(4): 1325 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Ponthan, M. Wickstrom, H. Gleissman, O. M. Fuskevag, L. Segerstrom, B. Sveinbjornsson, C. P.F. Redfern, S. Eksborg, P. Kogner, and J. I. Johnsen
Celecoxib Prevents Neuroblastoma Tumor Development and Potentiates the Effect of Chemotherapeutic Drugs In vitro and In vivo
Clin. Cancer Res., February 1, 2007; 13(3): 1036 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. E. Riehl, R. J. George, M. A. Sturmoski, R. May, B. Dieckgraefe, S. Anant, and C. W. Houchen
Azoxymethane protects intestinal stem cells and reduces crypt epithelial mitosis through a COX-1-dependent mechanism
Am J Physiol Gastrointest Liver Physiol, December 1, 2006; 291(6): G1062 - G1070.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
W.-C. Tsai, S.-T. Tsai, Y.-T. Jin, and L.-W. Wu
Cyclooxygenase-2 Is Involved in S100A2-Mediated Tumor Suppression in Squamous Cell Carcinoma
Mol. Cancer Res., August 1, 2006; 4(8): 539 - 547.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Muller, K. J. Sales, A. A. Katz, and H. N. Jabbour
Seminal Plasma Promotes the Expression of Tumorigenic and Angiogenic Genes in Cervical Adenocarcinoma Cells via the E-Series Prostanoid 4 Receptor
Endocrinology, July 1, 2006; 147(7): 3356 - 3365.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J Mrena, J-P Wiksten, S Nordling, A Kokkola, A Ristimaki, and C Haglund
MMP-2 but not MMP-9 associated with COX-2 and survival in gastric cancer.
J. Clin. Pathol., June 1, 2006; 59(6): 618 - 623.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. Wang, H. Wang, J. Brown, T. Daikoku, W. Ning, Q. Shi, A. Richmond, R. Strieter, S. K. Dey, and R. N. DuBois
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
J. Exp. Med., April 17, 2006; 203(4): 941 - 951.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Williams, S. H. Lee, M. Pollack, and I. A. Blair
Endogenous Lipid Hydroperoxide-mediated DNA-adduct Formation in Min Mice
J. Biol. Chem., April 14, 2006; 281(15): 10127 - 10133.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M.A. Hull, O.O. Faluyi, C.W.S. Ko, S. Holwell, D.J. Scott, R.J. Cuthbert, R. Poulsom, R. Goodlad, C. Bonifer, A.F. Markham, et al.
Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis
Carcinogenesis, March 1, 2006; 27(3): 382 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. R. Howe, S.-H. Chang, K. C. Tolle, R. Dillon, L. J.T. Young, R. D. Cardiff, R. A. Newman, P. Yang, H. T. Thaler, W. J. Muller, et al.
HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis Are Reduced in Cyclooxygenase-2 Knockout Mice
Cancer Res., November 1, 2005; 65(21): 10113 - 10119.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Mrena, J.-P. Wiksten, A. Thiel, A. Kokkola, L. Pohjola, J. Lundin, S. Nordling, A. Ristimaki, and C. Haglund
Cyclooxygenase-2 Is an Independent Prognostic Factor in Gastric Cancer and Its Expression Is Regulated by the Messenger RNA Stability Factor HuR
Clin. Cancer Res., October 15, 2005; 11(20): 7362 - 7368.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Yamaguchi, A. Lantowski, A. J. Dannenberg, and K. Subbaramaiah
Histone Deacetylase Inhibitors Suppress the Induction of c-Jun and Its Target Genes Including COX-2
J. Biol. Chem., September 23, 2005; 280(38): 32569 - 32577.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. Rigas and K. Kashfi
Cancer Prevention: A New Era beyond Cyclooxygenase-2
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. H.A. von Rahden, H. J. Stein, F. Puhringer, I. Koch, R. Langer, G. Piontek, J. R. Siewert, H. Hofler, and M. Sarbia
Coexpression of Cyclooxygenases (COX-1, COX-2) and Vascular Endothelial Growth Factors (VEGF-A, VEGF-C) in Esophageal Adenocarcinoma
Cancer Res., June 15, 2005; 65(12): 5038 - 5044.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. K. Altorki, J. L. Port, F. Zhang, D. Golijanin, H. T. Thaler, A. J. Duffield-Lillico, K. Subbaramaiah, and A. J. Dannenberg
Chemotherapy Induces the Expression of Cyclooxygenase-2 in Non-Small Cell Lung Cancer
Clin. Cancer Res., June 1, 2005; 11(11): 4191 - 4197.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. N. Davis, M. T. McCabe, S. W. Hayward, J. M. Park, and M. L. Day
Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells
Cancer Res., May 1, 2005; 65(9): 3633 - 3642.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. R. Brown and R. N. DuBois
COX-2: A Molecular Target for Colorectal Cancer Prevention
J. Clin. Oncol., April 20, 2005; 23(12): 2840 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Murakami, S. Masuda, K. Ueda-Semmyo, E. Yoda, H. Kuwata, Y. Takanezawa, J. Aoki, H. Arai, H. Sumimoto, Y. Ishikawa, et al.
Group VIB Ca2+-independent Phospholipase A2{gamma} Promotes Cellular Membrane Hydrolysis and Prostaglandin Production in a Manner Distinct from Other Intracellular Phospholipases A2
J. Biol. Chem., April 8, 2005; 280(14): 14028 - 14041.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y.N. Ye, W.K.K. Wu, V.Y. Shin, I.C. Bruce, B.C.Y. Wong, and C.H. Cho
Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke
Carcinogenesis, April 1, 2005; 26(4): 827 - 834.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. M. Ulrich, J. Whitton, J.-H. Yu, J. Sibert, R. Sparks, J. D. Potter, and J. Bigler
PTGS2 (COX-2) -765G > C Promoter Variant Reduces Risk of Colorectal Adenoma among Nonusers of Nonsteroidal Anti-inflammatory Drugs
Cancer Epidemiol. Biomarkers Prev., March 1, 2005; 14(3): 616 - 619.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Wang, F. G. Buchanan, H. Wang, S. K. Dey, and R. N. DuBois
Prostaglandin E2 Enhances Intestinal Adenoma Growth via Activation of the Ras-Mitogen-Activated Protein Kinase Cascade
Cancer Res., March 1, 2005; 65(5): 1822 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. I. Patel, K. Subbaramaiah, B. Du, M. Chang, P. Yang, R. A. Newman, C. Cordon-Cardo, H. T. Thaler, and A. J. Dannenberg
Celecoxib Inhibits Prostate Cancer Growth: Evidence of a Cyclooxygenase-2-Independent Mechanism
Clin. Cancer Res., March 1, 2005; 11(5): 1999 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. R. Paccani, L. Patrussi, C. Ulivieri, J. L. Masferrer, M. M. D'Elios, and C. T. Baldari
Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling
Blood, March 1, 2005; 105(5): 2042 - 2048.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Niho, M. Mutoh, M. Takahashi, K. Tsutsumi, T. Sugimura, and K. Wakabayashi
Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice
PNAS, February 22, 2005; 102(8): 2970 - 2974.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. L.E. Siezen, A. I.M. van Leeuwen, N. R. Kram, M. E.M. Luken, H. J. van Kranen, and E. Kampman
Colorectal adenoma risk is modified by the interplay between polymorphisms in arachidonic acid pathway genes and fish consumption
Carcinogenesis, February 1, 2005; 26(2): 449 - 457.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
T. Kawamori, T. Kitamura, K. Watanabe, N. Uchiya, T. Maruyama, S. Narumiya, T. Sugimura, and K. Wakabayashi
Prostaglandin E receptor subtype EP1 deficiency inhibits colon cancer development
Carcinogenesis, February 1, 2005; 26(2): 353 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Muller-Decker, I. Berger, K. Ackermann, V. Ehemann, S. Zoubova, S. Aulmann, W. Pyerin, and G. Furstenberger
Cystic Duct Dilatations and Proliferative Epithelial Lesions in Mouse Mammary Glands upon Keratin 5 Promoter-Driven Overexpression of Cyclooxygenase-2
Am. J. Pathol., February 1, 2005; 166(2): 575 - 584.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Moraitis, B. Du, M. S. De Lorenzo, J. O. Boyle, B. B. Weksler, E. G. Cohen, J. F. Carew, N. K. Altorki, L. Kopelovich, K. Subbaramaiah, et al.
Levels of Cyclooxygenase-2 Are Increased in the Oral Mucosa of Smokers: Evidence for the Role of Epidermal Growth Factor Receptor and Its Ligands
Cancer Res., January 15, 2005; 65(2): 664 - 670.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois
Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention
J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. T. Soumaoro, H. Uetake, T. Higuchi, Y. Takagi, M. Enomoto, and K. Sugihara
Cyclooxygenase-2 Expression: A Significant Prognostic Indicator for Patients With Colorectal Cancer
Clin. Cancer Res., December 15, 2004; 10(24): 8465 - 8471.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A J M Watson
Apoptosis and colorectal cancer
Gut, November 1, 2004; 53(11): 1701 - 1709.
[Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. L. Simmons, R. M. Botting, and T. Hla
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Pharmacol. Rev., September 1, 2004; 56(3): 387 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. A. Adegboyega, O. Ololade, J. Saada, R. Mifflin, J. F. Di Mari, and D. W. Powell
Subepithelial Myofibroblasts Express Cyclooxygenase-2 in Colorectal Tubular Adenomas
Clin. Cancer Res., September 1, 2004; 10(17): 5870 - 5879.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. P. Pentland, G. Scott, J. VanBuskirk, C. Tanck, G. LaRossa, and S. Brouxhon
Cyclooxygenase-1 Deletion Enhances Apoptosis but Does Not Protect Against Ultraviolet Light-Induced Tumors
Cancer Res., August 15, 2004; 64(16): 5587 - 5591.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. A. Hull, S. C.W. Ko, and G. Hawcroft
Prostaglandin EP receptors: Targets for treatment and prevention of colorectal cancer?
Mol. Cancer Ther., August 1, 2004; 3(8): 1031 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. M. Huycke and H. R. Gaskins
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
Experimental Biology and Medicine, July 1, 2004; 229(7): 586 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. C Larsson, M. Kumlin, M. Ingelman-Sundberg, and A. Wolk
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms
Am. J. Clinical Nutrition, June 1, 2004; 79(6): 935 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
C. M. Ulrich, J. Bigler, R. Sparks, J. Whitton, J. G. Sibert, E. L. Goode, Y. Yasui, and J. D. Potter
Polymorphisms in PTGS1 (=COX-1) and Risk of Colorectal Polyps
Cancer Epidemiol. Biomarkers Prev., May 1, 2004; 13(5): 889 - 893.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
F. G. Bottone Jr, J. M. Martinez, B. Alston-Mills, and T. E. Eling
Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells
Carcinogenesis, March 1, 2004; 25(3): 349 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Golijanin, J.-Y. Tan, A. Kazior, E. G. Cohen, P. Russo, G. Dalbagni, K. J. Auborn, K. Subbaramaiah, and A. J. Dannenberg
Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
Clin. Cancer Res., February 1, 2004; 10(3): 1024 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T.-L. Erkinheimo, H. Lassus, P. Finne, B. P. van Rees, A. Leminen, O. Ylikorkala, C. Haglund, R. Butzow, and A. Ristimaki
Elevated Cyclooxygenase-2 Expression Is Associated with Altered Expression of p53 and SMAD4, Amplification of HER-2/neu, and Poor Outcome in Serous Ovarian Carcinoma
Clin. Cancer Res., January 15, 2004; 10(2): 538 - 545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Puxeddu, N. Mitsutake, J. A. Knauf, S. Moretti, H. W. Kim, K. A. Seta, D. Brockman, L. Myatt, D. E. Millhorn, and J. A. Fagin
Microsomal Prostaglandin E2 Synthase-1 Is Induced by Conditional Expression of RET/PTC in Thyroid PCCL3 Cells through the Activation of the MEK-ERK Pathway
J. Biol. Chem., December 26, 2003; 278(52): 52131 - 52138.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. ROMANO and J. CLARIA
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy
FASEB J, November 1, 2003; 17(14): 1986 - 1995.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Subbaramaiah, T. P. Marmo, D. A. Dixon, and A. J. Dannenberg
Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes: EVIDENCE FOR INVOLVEMENT OF p38, MAPKAPK-2, and HuR
J. Biol. Chem., September 26, 2003; 278(39): 37637 - 37647.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Salcedo, X. Zhang, H. A. Young, N. Michael, K. Wasserman, W.-H. Ma, M. Martins-Green, W. J. Murphy, and J. J. Oppenheim
Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells
Blood, September 15, 2003; 102(6): 1966 - 1977.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Takeda, M. Sonoshita, H. Oshima, K.-i. Sugihara, P. C. Chulada, R. Langenbach, M. Oshima, and M. M. Taketo
Cooperation of Cyclooxygenase 1 and Cyclooxygenase 2 in Intestinal Polyposis
Cancer Res., August 15, 2003; 63(16): 4872 - 4877.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. L. Kettunen, A. S. L. Kettunen, and N. E. Rautonen
Intestinal Immune Responses in Wild-Type and ApcMin/+ Mouse, a Model for Colon Cancer
Cancer Res., August 15, 2003; 63(16): 5136 - 5142.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Nishihara, S. Kizaka-Kondoh, P. A. Insel, and L. Eckmann
Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2
PNAS, July 22, 2003; 100(15): 8921 - 8926.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. Hawcroft, S. H. Gardner, and M. A. Hull
Activation of Peroxisome Proliferator-Activated Receptor gamma Does Not Explain the Antiproliferative Activity of the Nonsteroidal Anti-Inflammatory Drug Indomethacin on Human Colorectal Cancer Cells
J. Pharmacol. Exp. Ther., May 1, 2003; 305(2): 632 - 637.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. Klatt and M. Serrano
Engineering cancer resistance in mice
Carcinogenesis, May 1, 2003; 24(5): 817 - 826.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
T. Kawamori, N. Uchiya, T. Sugimura, and K. Wakabayashi
Enhancement of colon carcinogenesis by prostaglandin E2 administration
Carcinogenesis, May 1, 2003; 24(5): 985 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. S. Cutler, R. Graves-Deal, B. J. LaFleur, Z. Gao, B. M. Boman, R. H. Whitehead, E. Terry, J. D. Morrow, and R. J. Coffey
Stromal Production of Prostacyclin Confers an Antiapoptotic Effect to Colonic Epithelial Cells
Cancer Res., April 15, 2003; 63(8): 1748 - 1751.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Fujino, W. Xu, and J. W. Regan
Prostaglandin E2 Induced Functional Expression of Early Growth Response Factor-1 by EP4, but Not EP2, Prostanoid Receptors via the Phosphatidylinositol 3-Kinase and Extracellular Signal-regulated Kinases
J. Biol. Chem., March 28, 2003; 278(14): 12151 - 12156.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. A. Gupta, L. V. Tejada, B. J. Tong, S. K. Das, J. D. Morrow, S. K. Dey, and R. N. DuBois
Cyclooxygenase-1 is Overexpressed and Promotes Angiogenic Growth Factor Production in Ovarian Cancer
Cancer Res., March 1, 2003; 63(5): 906 - 911.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. W. Houchen, M. A. Sturmoski, S. Anant, R. M. Breyer, and W. F. Stenson
Prosurvival and antiapoptotic effects of PGE2 in radiation injury are mediated by EP2 receptor in intestine
Am J Physiol Gastrointest Liver Physiol, March 1, 2003; 284(3): G490 - G498.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S. Tokudome, Y. Yokoyama, T. Kamiya, K. Seno, H. Okuyama, K. Kuriki, J. Cheng, T. Nakamura, T. Fujii, H. Ichikawa, et al.
Rati