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[Cancer Research 60, 4709-4713, September 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

ß-Catenin Affects Androgen Receptor Transcriptional Activity and Ligand Specificity1

Cristina I. Truica, Stephen Byers and Edward P. Gelmann2

Lombardi Cancer Center, Georgetown University, Washington, D.C. 20007-2197

ß-Catenin is a multifunctional molecule with important roles in intercellular adhesion and signal transduction. We reported previously that ß-catenin is mutated in human prostate cancer. In this study, we investigated the role of ß-catenin mutations on androgen receptor (AR) signaling. ß-Catenin significantly enhanced androgen-stimulated transcriptional activation by the AR. ß-Catenin also increased AR transcriptional activation by androstenedione and estradiol and diminished the antagonism of bicalutamide. Coimmunoprecipitation of ß-catenin with AR from LNCaP prostate cancer cells showed that the two molecules are present in the same complex. The amount of ß-catenin in complex with AR was increased by androgen. These findings implicate ß-catenin in the regulation of AR function and support a role for ß-catenin mutations in the pathogenesis of prostate cancer.




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