| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Laboratories of Molecular Medicine [K. On., T. Tan., O. K., C. K., Y. N.] and Genome Database [T. Ts., T. Tak.], Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan [A. O., K. Oc.]
To identify genes involved in the development or progression of ovarian cancer, we analyzed gene expression profiles of nine ovarian tumors using a DNA microarray consisting of 9121 genes. Comparison of expression patterns between carcinomas and the corresponding normal ovarian tissues enabled us to identify 55 genes that were commonly up-regulated and 48 genes that were down-regulated in the cancer specimens. When the five serous adenocarcinomas were analyzed separately from the four mucinous adenocarcinomas, we identified 115 genes that were expressed differently between the two types of tumor. Investigation of these genes should help to disclose the molecular mechanism(s) of ovarian carcinogenesis and define molecular separation of the two most common histological types of ovarian cancer.
This article has been cited by other articles:
![]() |
A. B. Tchagang, A. H. Tewfik, M. S. DeRycke, K. M. Skubitz, and A. P.N. Skubitz Early detection of ovarian cancer using group biomarkers Mol. Cancer Ther., January 1, 2008; 7(1): 27 - 37. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. K. Dressman, A. Berchuck, G. Chan, J. Zhai, A. Bild, R. Sayer, J. Cragun, J. Clarke, R. S. Whitaker, L. Li, et al. An Integrated Genomic-Based Approach to Individualized Treatment of Patients With Advanced-Stage Ovarian Cancer J. Clin. Oncol., February 10, 2007; 25(5): 517 - 525. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Okamoto, T. Nikaido, K. Ochiai, S. Takakura, M. Saito, Y. Aoki, N. Ishii, N. Yanaihara, K. Yamada, O. Takikawa, et al. Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells Clin. Cancer Res., August 15, 2005; 11(16): 6030 - 6039. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. G. Peters, D. M. Kudla, J. A. DeLoia, T. J. Chu, L. Fairfull, R. P. Edwards, and R. E. Ferrell Comparative Gene Expression Analysis of Ovarian Carcinoma and Normal Ovarian Epithelium by Serial Analysis of Gene Expression Cancer Epidemiol. Biomarkers Prev., July 1, 2005; 14(7): 1717 - 1723. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. J. Yang, M.-H. Tan, H. L. Kim, J. A. Ditlev, M. W. Betten, C. E. Png, E. J. Kort, K. Futami, K. A. Furge, M. Takahashi, et al. A Molecular Classification of Papillary Renal Cell Carcinoma Cancer Res., July 1, 2005; 65(13): 5628 - 5637. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Togashi, T. Katagiri, S. Ashida, T. Fujioka, O. Maruyama, Y. Wakumoto, Y. Sakamoto, M. Fujime, Y. Kawachi, T. Shuin, et al. Hypoxia-Inducible Protein 2 (HIG2), a Novel Diagnostic Marker for Renal Cell Carcinoma and Potential Target for Molecular Therapy Cancer Res., June 1, 2005; 65(11): 4817 - 4826. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. D. Santin, S. Cane, S. Bellone, M. Palmieri, E. R. Siegel, M. Thomas, J. J. Roman, A. Burnett, M. J. Cannon, and S. Pecorelli Treatment of Chemotherapy-Resistant Human Ovarian Cancer Xenografts in C.B-17/SCID Mice by Intraperitoneal Administration of Clostridium perfringens Enterotoxin Cancer Res., May 15, 2005; 65(10): 4334 - 4342. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Berchuck, E. S. Iversen, J. M. Lancaster, J. Pittman, J. Luo, P. Lee, S. Murphy, H. K. Dressman, P. G. Febbo, M. West, et al. Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers Clin. Cancer Res., May 15, 2005; 11(10): 3686 - 3696. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Takata, T. Katagiri, M. Kanehira, T. Tsunoda, T. Shuin, T. Miki, M. Namiki, K. Kohri, Y. Matsushita, T. Fujioka, et al. Predicting Response to Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Neoadjuvant Chemotherapy for Bladder Cancers through Genome-Wide Gene Expression Profiling Clin. Cancer Res., April 1, 2005; 11(7): 2625 - 2636. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Drapkin, H. H. von Horsten, Y. Lin, S. C. Mok, C. P. Crum, W. R. Welch, and J. L. Hecht Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas Cancer Res., March 15, 2005; 65(6): 2162 - 2169. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. C. Hartmann, K. H. Lu, G. P. Linette, W. A. Cliby, K. R. Kalli, D. Gershenson, R. C. Bast, J. Stec, N. Iartchouk, D. I. Smith, et al. Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy Clin. Cancer Res., March 15, 2005; 11(6): 2149 - 2155. [Abstract] [Full Text] [PDF] |
||||
![]() |
W.-R. Park and Y. Nakamura p53CSV, a Novel p53-Inducible Gene Involved in the p53-Dependent Cell-Survival Pathway Cancer Res., February 15, 2005; 65(4): 1197 - 1206. [Abstract] [Full Text] [PDF] |
||||
![]() |
M Onda, M Emi, A Yoshida, S Miyamoto, J Akaishi, S Asaka, K Mizutani, K Shimizu, M Nagahama, K Ito, et al. Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25 344 genes Endocr. Relat. Cancer, December 1, 2004; 11(4): 843 - 854. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. DEVOOGDT, H. REVETS, G. H. GHASSABEH, and P. DE BAETSELIER Secretory Leukocyte Protease Inhibitor in Cancer Development Ann. N.Y. Acad. Sci., December 1, 2004; 1028(1): 380 - 389. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Melov and A. Hubbard Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future Sci. Aging Knowl. Environ., October 20, 2004; 2004(42): re7 - re7. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Matar, F. Rojo, R. Cassia, G. Moreno-Bueno, S. Di Cosimo, J. Tabernero, M. Guzman, S. Rodriguez, J. Arribas, J. Palacios, et al. Combined Epidermal Growth Factor Receptor Targeting with the Tyrosine Kinase Inhibitor Gefitinib (ZD1839) and the Monoclonal Antibody Cetuximab (IMC-C225): Superiority Over Single-Agent Receptor Targeting Clin. Cancer Res., October 1, 2004; 10(19): 6487 - 6501. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Ashida, H. Nakagawa, T. Katagiri, M. Furihata, M. Iiizumi, Y. Anazawa, T. Tsunoda, R. Takata, K. Kasahara, T. Miki, et al. Molecular Features of the Transition from Prostatic Intraepithelial Neoplasia (PIN) to Prostate Cancer: Genome-wide Gene-expression Profiles of Prostate Cancers and PINs Cancer Res., September 1, 2004; 64(17): 5963 - 5972. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Hibbs, K. M. Skubitz, S. E. Pambuccian, R. C. Casey, K. M. Burleson, T. R. Oegema Jr, J. J. Thiele, S. M. Grindle, R. L. Bliss, and A. P.N. Skubitz Differential Gene Expression in Ovarian Carcinoma: Identification of Potential Biomarkers Am. J. Pathol., August 1, 2004; 165(2): 397 - 414. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bali, P. M. O'Brien, L. S. Edwards, R. L. Sutherland, N. F. Hacker, and S. M. Henshall Cyclin D1, p53, and p21Waf1/Cip1 Expression Is Predictive of Poor Clinical Outcome in Serous Epithelial Ovarian Cancer Clin. Cancer Res., August 1, 2004; 10(15): 5168 - 5177. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Widschwendter, G. Jiang, C. Woods, H. M. Muller, H. Fiegl, G. Goebel, C. Marth, E. Muller-Holzner, A. G. Zeimet, P. W. Laird, et al. DNA Hypomethylation and Ovarian Cancer Biology Cancer Res., July 1, 2004; 64(13): 4472 - 4480. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. A. Heinzelmann-Schwarz, M. Gardiner-Garden, S. M. Henshall, J. Scurry, R. A. Scolyer, M. J. Davies, M. Heinzelmann, L. H. Kalish, A. Bali, J. G. Kench, et al. Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer Clin. Cancer Res., July 1, 2004; 10(13): 4427 - 4436. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Lancaster, H. K. Dressman, R. S. Whitaker, L. Havrilesky, J. Gray, J. R. Marks, J. R. Nevins, and A. Berchuck Gene Expression Patterns That Characterize Advanced Stage Serous Ovarian Cancers Reproductive Sciences, January 1, 2004; 11(1): 51 - 59. [Abstract] [PDF] |
||||
![]() |
Y. Sasaki, H. Mita, M. Toyota, S. Ishida, I. Morimoto, T. Yamashita, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino Identification of the Interleukin 4 Receptor {alpha} Gene as a Direct Target for p73 Cancer Res., December 1, 2003; 63(23): 8145 - 8152. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Tsuchiya, M. Sakamoto, J. Yasuda, M. Chuma, T. Ohta, M. Ohki, T. Yasugi, Y. Taketani, and S. Hirohashi Expression Profiling in Ovarian Clear Cell Carcinoma: Identification of Hepatocyte Nuclear Factor-1{beta} as a Molecular Marker and a Possible Molecular Target for Therapy of Ovarian Clear Cell Carcinoma Am. J. Pathol., December 1, 2003; 163(6): 2503 - 2512. [Abstract] [Full Text] |
||||
![]() |
M. E. Schaner, D. T. Ross, G. Ciaravino, T. Sorlie, O. Troyanskaya, M. Diehn, Y. C. Wang, G. E. Duran, T. L. Sikic, S. Caldeira, et al. Gene Expression Patterns in Ovarian Carcinomas Mol. Biol. Cell, November 1, 2003; 14(11): 4376 - 4386. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. K. Zorn, A. A. Jazaeri, C. S. Awtrey, G. J. Gardner, S. C. Mok, J. Boyd, and M. J. Birrer Choice of Normal Ovarian Control Influences Determination of Differentially Expressed Genes in Ovarian Cancer Expression Profiling Studies Clin. Cancer Res., October 15, 2003; 9(13): 4811 - 4818. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Moreno-Bueno, C. Sanchez-Estevez, R. Cassia, S. Rodriguez-Perales, R. Diaz-Uriarte, O. Dominguez, D. Hardisson, M. Andujar, J. Prat, X. Matias-Guiu, et al. Differential Gene Expression Profile in Endometrioid and Nonendometrioid Endometrial Carcinoma: STK15 Is Frequently Overexpressed and Amplified in Nonendometrioid Carcinomas Cancer Res., September 15, 2003; 63(18): 5697 - 5702. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Kaminski, J. A. Belperio, P. B. Bitterman, L. Chen, S. W. Chensue, A. M.K. Choi, S. Dacic, J. H. Dauber, R. M. du Bois, J. J. Enghild, et al. Idiopathic Pulmonary Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): S1 - 105. [Full Text] [PDF] |
||||
![]() |
I. Hellstrom, J. Raycraft, M. Hayden-Ledbetter, J. A. Ledbetter, M. Schummer, M. McIntosh, C. Drescher, N. Urban, and K. E. Hellstrom The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma Cancer Res., July 1, 2003; 63(13): 3695 - 3700. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Lancaster, R. Sayer, C. Blanchette, B. Calingaert, R. Whitaker, J. Schildkraut, J. Marks, and A. Berchuck High Expression of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Is Associated with Favorable Ovarian Cancer Survival Clin. Cancer Res., February 1, 2003; 9(2): 762 - 766. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Takahashi, M. Fujita, Y. Furukawa, R. Hamamoto, T. Shimokawa, N. Miwa, M. Ogawa, and Y. Nakamura Isolation of a Novel Human Gene, APCDD1, as a Direct Target of the {beta}-Catenin/T-Cell Factor 4 Complex with Probable Involvement in Colorectal Carcinogenesis Cancer Res., October 15, 2002; 62(20): 5651 - 5656. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nagayama, T. Katagiri, T. Tsunoda, T. Hosaka, Y. Nakashima, N. Araki, K. Kusuzaki, T. Nakayama, T. Tsuboyama, T. Nakamura, et al. Genome-wide Analysis of Gene Expression in Synovial Sarcomas Using a cDNA Microarray Cancer Res., October 15, 2002; 62(20): 5859 - 5866. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-i. Okutsu, T. Tsunoda, Y. Kaneta, T. Katagiri, O. Kitahara, H. Zembutsu, R. Yanagawa, S. Miyawaki, K. Kuriyama, N. Kubota, et al. Prediction of Chemosensitivity for Patients with Acute Myeloid Leukemia, According to Expression Levels of 28 Genes Selected by Genome-wide Complementary DNA Microarray Analysis, Mol. Cancer Ther., October 1, 2002; 1(12): 1035 - 1042. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Hilton, J. P. Geisler, J. A. Rathe, M. A. Hattermann-Zogg, B. DeYoung, and R. E. Buller Inactivation of BRCA1 and BRCA2 in Ovarian Cancer J Natl Cancer Inst, September 18, 2002; 94(18): 1396 - 1406. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. R. Schwartz, S. L. R. Kardia, K. A. Shedden, R. Kuick, G. Michailidis, J. M. G. Taylor, D. E. Misek, R. Wu, Y. Zhai, D. M. Darrah, et al. Gene Expression in Ovarian Cancer Reflects Both Morphology and Biological Behavior, Distinguishing Clear Cell from Other Poor-Prognosis Ovarian Carcinomas Cancer Res., August 15, 2002; 62(16): 4722 - 4729. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Mohr, G. D. Leikauf, G. Keith, and B. H. Rihn Microarrays as Cancer Keys: An Array of Possibilities J. Clin. Oncol., July 15, 2002; 20(14): 3165 - 3175. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Miura, E. D. Bowman, R. Simon, A. C. Peng, A. I. Robles, R. T. Jones, T. Katagiri, P. He, H. Mizukami, L. Charboneau, et al. Laser Capture Microdissection and Microarray Expression Analysis of Lung Adenocarcinoma Reveals Tobacco Smoking- and Prognosis-related Molecular Profiles Cancer Res., June 1, 2002; 62(11): 3244 - 3250. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Bayani, J. D. Brenton, P. F. Macgregor, B. Beheshti, M. Albert, D. Nallainathan, J. Karaskova, B. Rosen, J. Murphy, S. Laframboise, et al. Parallel Analysis of Sporadic Primary Ovarian Carcinomas by Spectral Karyotyping, Comparative Genomic Hybridization, and Expression Microarrays Cancer Res., June 1, 2002; 62(12): 3466 - 3476. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Scheidl, S. Nilsson, M. Kalen, M. Hellstrom, M. Takemoto, J. Hakansson, and P. Lindahl mRNA Expression Profiling of Laser Microbeam Microdissected Cells from Slender Embryonic Structures Am. J. Pathol., March 1, 2002; 160(3): 801 - 813. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Dan, T. Tsunoda, O. Kitahara, R. Yanagawa, H. Zembutsu, T. Katagiri, K. Yamazaki, Y. Nakamura, and T. Yamori An Integrated Database of Chemosensitivity to 55 Anticancer Drugs and Gene Expression Profiles of 39 Human Cancer Cell Lines Cancer Res., February 1, 2002; 62(4): 1139 - 1147. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Sasaki, S. Ishida, I. Morimoto, T. Yamashita, T. Kojima, C. Kihara, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino The p53 Family Member Genes Are Involved in the Notch Signal Pathway J. Biol. Chem., January 4, 2002; 277(1): 719 - 724. [Abstract] [Full Text] |
||||
![]() |
H. Zembutsu, Y. Ohnishi, T. Tsunoda, Y. Furukawa, T. Katagiri, Y. Ueyama, N. Tamaoki, T. Nomura, O. Kitahara, R. Yanagawa, et al. Genome-wide cDNA Microarray Screening to Correlate Gene Expression Profiles with Sensitivity of 85 Human Cancer Xenografts to Anticancer Drugs Cancer Res., January 1, 2002; 62(2): 518 - 527. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Fujita, Y. Furukawa, T. Tsunoda, T. Tanaka, M. Ogawa, and Y. Nakamura Up-Regulation of the Ectodermal-Neural Cortex 1 (ENC1) Gene, a Downstream Target of the {beta}-Catenin/T-Cell Factor Complex, in Colorectal Carcinomas Cancer Res., November 1, 2001; 61(21): 7722 - 7726. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Wiechen, L. Diatchenko, A. Agoulnik, K. M. Scharff, H. Schober, K. Arlt, B. Zhumabayeva, P. D. Siebert, M. Dietel, R. Schafer, et al. Caveolin-1 Is Down-Regulated in Human Ovarian Carcinoma and Acts as a Candidate Tumor Suppressor Gene Am. J. Pathol., November 1, 2001; 159(5): 1635 - 1643. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Kihara, T. Tsunoda, T. Tanaka, H. Yamana, Y. Furukawa, K. Ono, O. Kitahara, H. Zembutsu, R. Yanagawa, K. Hirata, et al. Prediction of Sensitivity of Esophageal Tumors to Adjuvant Chemotherapy by cDNA Microarray Analysis of Gene-Expression Profiles Cancer Res., September 1, 2001; 61(17): 6474 - 6479. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Y. Ljubimova, A. J. Lakhter, A. Loksh, W. H. Yong, M. S. Riedinger, J. H. Miner, L. M. Sorokin, A. V. Ljubimov, and K. L. Black Overexpression of {alpha}4 Chain-containing Laminins in Human Glial Tumors Identified by Gene Microarray Analysis Cancer Res., July 1, 2001; 61(14): 5601 - 5610. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Luo, D. J. Duggan, Y. Chen, J. Sauvageot, C. M. Ewing, M. L. Bittner, J. M. Trent, and W. B. Isaacs Human Prostate Cancer and Benign Prostatic Hyperplasia: Molecular Dissection by Gene Expression Profiling Cancer Res., June 1, 2001; 61(12): 4683 - 4688. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, M. E. Nita, T. Takagi, Y. Nakamura, and T. Tsunoda Alterations of Gene Expression during Colorectal Carcinogenesis Revealed by cDNA Microarrays after Laser-Capture Microdissection of Tumor Tissues and Normal Epithelia Cancer Res., May 1, 2001; 61(9): 3544 - 3549. [Abstract] [Full Text] |
||||
![]() |
H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa, and Y. Nakamura Genome-wide Analysis of Gene Expression in Human Hepatocellular Carcinomas Using cDNA Microarray: Identification of Genes Involved in Viral Carcinogenesis and Tumor Progression Cancer Res., March 1, 2001; 61(5): 2129 - 2137. [Abstract] [Full Text] |
||||
![]() |
J. B. Welsh, P. P. Zarrinkar, L. M. Sapinoso, S. G. Kern, C. A. Behling, B. J. Monk, D. J. Lockhart, R. A. Burger, and G. M. Hampton Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer PNAS, January 30, 2001; 98(3): 1176 - 1181. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |