Cancer Research Grants Frontiers in Basic Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Okegawa, T.
Right arrow Articles by Hsieh, J.-T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Okegawa, T.
Right arrow Articles by Hsieh, J.-T.
[Cancer Research 60, 5031-5036, September 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

The Dual Impact of Coxsackie and Adenovirus Receptor Expression on Human Prostate Cancer Gene Therapy1

Takatsugu Okegawa2, Yingming Li2, Rey-Chen Pong, Jeffrey M. Bergelson, Jian Zhou and Jer-Tsong Hsieh3

Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 [T. O., Y. L., R. C. P., J. Z., J. T. H.], and Division of Immunologic and Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19100 [J. M. B.]

In a recent paper, we reported a significant difference in coxsackie and adenovirus receptor (CAR) from several human bladder cancer cell lines that correlated with their sensitivities to adenoviral infection (Y. Li, R-C. Pong, J. M. Bergelson, M, C. Hall, A. I. Sagalowsky, C-P. Tseng, Z. Wang, and J. T. Hsieh, Cancer Res., 59: 325–330, 1999). In human prostate cancer, CAR protein is down-regulated in the highly tumorigenic PC3 cell line, which suggests that, in addition to its function as a viral receptor, CAR may have a pathophysiological role in prostate cancer progression. In this paper, we document that CAR does not merely enhance the viral sensitivity of prostate cancer cells but also acts as a tumor inhibitor for androgen-independent prostate cancer cells. Our data indicate that CAR is a potential therapeutic agent for increasing the efficacy of prostate cancer therapy.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
S. Ganesh, M. Gonzalez-Edick, D. Gibbons, M. Van Roey, and K. Jooss
Intratumoral Coadministration of Hyaluronidase Enzyme and Oncolytic Adenoviruses Enhances Virus Potency in Metastatic Tumor Models
Clin. Cancer Res., June 15, 2008; 14(12): 3933 - 3941.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. E. Lupold, T. A. Kudrolli, W. H. Chowdhury, P. Wu, and R. Rodriguez
A novel method for generating and screening peptides and libraries displayed on adenovirus fiber
Nucleic Acids Res., November 29, 2007; 35(20): e138 - e138.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
K. Guse, T. Ranki, M. Ala-Opas, P. Bono, M. Sarkioja, M. Rajecki, A. Kanerva, T. Hakkarainen, and A. Hemminki
Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses
Mol. Cancer Ther., October 1, 2007; 6(10): 2728 - 2736.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H.-J. Li, M. Everts, L. Pereboeva, S. Komarova, A. Idan, D. T. Curiel, and H. R. Herschman
Adenovirus Tumor Targeting and Hepatic Untargeting by a Coxsackie/Adenovirus Receptor Ectodomain Anti-Carcinoembryonic Antigen Bispecific Adapter
Cancer Res., June 1, 2007; 67(11): 5354 - 5361.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Ganesh, M. Gonzalez Edick, N. Idamakanti, M. Abramova, M. VanRoey, M. Robinson, C.-O. Yun, and K. Jooss
Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice
Cancer Res., May 1, 2007; 67(9): 4399 - 4407.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. T. Fok, K.-C. Huang, P. C. Holland, and J. Nalbantoglu
The Coxsackie and Adenovirus Receptor Binds Microtubules and Plays a Role in Cell Migration
J. Biol. Chem., March 9, 2007; 282(10): 7512 - 7521.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Rajecki, A. Kanerva, U.-H. Stenman, M. Tenhunen, L. Kangasniemi, M. Sarkioja, M. Y. Ala-Opas, H. Alfthan, A. Sankila, E. Rintala, et al.
Treatment of prostate cancer with Ad5/3{Delta}24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo
Mol. Cancer Ther., February 1, 2007; 6(2): 742 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R.-C. Pong, R. Roark, J.-Y. Ou, J. Fan, J. Stanfield, E. Frenkel, A. Sagalowsky, and J.-T. Hsieh
Mechanism of Increased Coxsackie and Adenovirus Receptor Gene Expression and Adenovirus Uptake by Phytoestrogen and Histone Deacetylase Inhibitor in Human Bladder Cancer Cells and the Potential Clinical Application.
Cancer Res., September 1, 2006; 66(17): 8822 - 8828.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-W. Chen, B. Zhou, Q.-C. Yu, S. J. Shin, K. Jiao, M. D. Schneider, H. S. Baldwin, and J. M. Bergelson
Cardiomyocyte-Specific Deletion of the Coxsackievirus and Adenovirus Receptor Results in Hyperplasia of the Embryonic Left Ventricle and Abnormalities of Sinuatrial Valves
Circ. Res., April 14, 2006; 98(7): 923 - 930.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. D. Lacher, M. I. Tiirikainen, E. F. Saunier, C. Christian, M. Anders, M. Oft, A. Balmain, R. J. Akhurst, and W. M. Korn
Transforming Growth Factor-{beta} Receptor Inhibition Enhances Adenoviral Infectability of Carcinoma Cells via Up-Regulation of Coxsackie and Adenovirus Receptor in Conjunction with Reversal of Epithelial-Mesenchymal Transition
Cancer Res., February 1, 2006; 66(3): 1648 - 1657.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Bruning, E. Stickeler, D. Diederich, L. Walz, H. Rohleder, K. Friese, and I. B. Runnebaum
Coxsackie and Adenovirus Receptor Promotes Adenocarcinoma Cell Survival and Is Expressionally Activated after Transition from Preneoplastic Precursor Lesions to Invasive Adenocarcinomas
Clin. Cancer Res., June 15, 2005; 11(12): 4316 - 4320.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Yotnda, B. Savoldo, N. Charlet-Berguerand, C. Rooney, and M. Brenner
Targeted delivery of adenoviral vectors by cytotoxic T cells
Blood, October 15, 2004; 104(8): 2272 - 2280.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Qin, B. Escuadro, M. Dohadwala, S. Sharma, and R. K. Batra
A Novel Role for the Coxsackie Adenovirus Receptor in Mediating Tumor Formation by Lung Cancer Cells
Cancer Res., September 15, 2004; 64(18): 6377 - 6380.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. J. D. A. Excoffon, A. Hruska-Hageman, M. Klotz, G. L. Traver, and J. Zabner
A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth
J. Cell Sci., September 1, 2004; 117(19): 4401 - 4409.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
V. Awasthi, G. Meinken, K. Springer, S. C. Srivastava, and P. Freimuth
Biodistribution of Radioiodinated Adenovirus Fiber Protein Knob Domain after Intravenous Injection in Mice
J. Virol., June 15, 2004; 78(12): 6431 - 6438.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Gu, A. Ogose, H. Kawashima, M. Ito, T. Ito, A. Matsuba, H. Kitahara, T. Hotta, K. Tokunaga, H. Hatano, et al.
High-Level Expression of the Coxsackievirus and Adenovirus Receptor Messenger RNA in Osteosarcoma, Ewing's Sarcoma, and Benign Neurogenic Tumors among Musculoskeletal Tumors
Clin. Cancer Res., June 1, 2004; 10(11): 3831 - 3838.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Raschperger, U. Engstrom, R. F. Pettersson, and J. Fuxe
CLMP, a Novel Member of the CTX Family and a New Component of Epithelial Tight Junctions
J. Biol. Chem., January 2, 2004; 279(1): 796 - 804.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R.-C. Pong, Y.-J. Lai, H. Chen, T. Okegawa, E. Frenkel, A. Sagalowsky, and J.-T. Hsieh
Epigenetic Regulation of Coxsackie and Adenovirus Receptor (CAR) Gene Promoter in Urogenital Cancer Cells
Cancer Res., December 15, 2003; 63(24): 8680 - 8686.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. Belousova, N. Korokhov, V. Krendelshchikova, V. Simonenko, G. Mikheeva, P. L. Triozzi, W. A. Aldrich, P. T. Banerjee, S. D. Gillies, D. T. Curiel, et al.
Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells
J. Virol., November 1, 2003; 77(21): 11367 - 11377.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Anders, C. Christian, M. McMahon, F. McCormick, and W. M. Korn
Inhibition of the Raf/MEK/ERK Pathway Up-Regulates Expression of the Coxsackievirus and Adenovirus Receptor in Cancer Cells
Cancer Res., May 1, 2003; 63(9): 2088 - 2095.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Sollerbrant, E. Raschperger, M. Mirza, U. Engstrom, L. Philipson, P. O. Ljungdahl, and R. F. Pettersson
The Coxsackievirus and Adenovirus Receptor (CAR) Forms a Complex with the PDZ Domain-containing Protein Ligand-of-Numb Protein-X (LNX)
J. Biol. Chem., February 21, 2003; 278(9): 7439 - 7444.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Anders, R. Hansen, R.-X. Ding, K. A. Rauen, M. J. Bissell, and W. M. Korn
Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor
PNAS, February 18, 2003; 100(4): 1943 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. Belousova, V. Krendelchtchikova, D. T. Curiel, and V. Krasnykh
Modulation of Adenovirus Vector Tropism via Incorporation of Polypeptide Ligands into the Fiber Protein
J. Virol., July 29, 2002; 76(17): 8621 - 8631.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. A. Rauen, D. Sudilovsky, J. L. Le, K. L. Chew, B. Hann, V. Weinberg, L. D. Schmitt, and F. McCormick
Expression of the Coxsackie Adenovirus Receptor in Normal Prostate and in Primary and Metastatic Prostate Carcinoma: Potential Relevance to Gene Therapy
Cancer Res., July 1, 2002; 62(13): 3812 - 3818.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. Hemminki, K. R. Zinn, B. Liu, T. R. Chaudhuri, R. A. Desmond, B. E. Rogers, M. N. Barnes, R. D. Alvarez, and D. T. Curiel
In Vivo Molecular Chemotherapy and Noninvasive Imaging With an Infectivity-Enhanced Adenovirus
J Natl Cancer Inst, May 15, 2002; 94(10): 741 - 749.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W. van't Hof and R. G. Crystal
Fatty Acid Modification of the Coxsackievirus and Adenovirus Receptor
J. Virol., May 15, 2002; 76(12): 6382 - 6386.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. M. Shayakhmetov, Z.-Y. Li, S. Ni, and A. Lieber
Targeting of Adenovirus Vectors to Tumor Cells Does Not Enable Efficient Transduction of Breast Cancer Metastases
Cancer Res., February 1, 2002; 62(4): 1063 - 1068.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. A. Kashentseva, T. Seki, D. T. Curiel, and I. P. Dmitriev
Adenovirus Targeting to c-erbB-2 Oncoprotein by Single-Chain Antibody Fused to Trimeric Form of Adenovirus Receptor Ectodomain
Cancer Res., January 1, 2002; 62(2): 609 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Kanerva, G. V. Mikheeva, V. Krasnykh, C. J. Coolidge, J. T. Lam, P. J. Mahasreshti, S. D. Barker, M. Straughn, M. N. Barnes, R. D. Alvarez, et al.
Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells
Clin. Cancer Res., January 1, 2002; 8(1): 275 - 280.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Pramudji, S. Shimura, S. Ebara, G. Yang, J. Wang, C. Ren, Y. Yuan, S. A. Tahir, T. L. Timme, and T. C. Thompson
In Situ Prostate Cancer Gene Therapy Using a Novel Adenoviral Vector Regulated by the Caveolin-1 Promoter
Clin. Cancer Res., December 1, 2001; 7(12): 4272 - 4279.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Hemminki, I. Dmitriev, B. Liu, R. A. Desmond, R. Alemany, and D. T. Curiel
Targeting Oncolytic Adenoviral Agents to the Epidermal Growth Factor Pathway with a Secretory Fusion Molecule
Cancer Res., September 1, 2001; 61(17): 6377 - 6381.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Okegawa, R.-C. Pong, Y. Li, J. M. Bergelson, A. I. Sagalowsky, and J.-T. Hsieh
The Mechanism of the Growth-inhibitory Effect of Coxsackie and Adenovirus Receptor (CAR) on Human Bladder Cancer: A Functional Analysis of CAR Protein Structure
Cancer Res., September 1, 2001; 61(17): 6592 - 6600.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Tallone, S. Malin, A. Samuelsson, J. Wilbertz, M. Miyahara, K. Okamoto, L. Poellinger, L. Philipson, and S. Pettersson
A mouse model for adenovirus gene delivery
PNAS, July 3, 2001; 98(14): 7910 - 7915.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. P. Cripe, E. J. Dunphy, A. D. Holub, A. Saini, N. H. Vasi, Y. Y. Mahller, M. H. Collins, J. D. Snyder, V. Krasnykh, D. T. Curiel, et al.
Fiber Knob Modifications Overcome Low, Heterogeneous Expression of the Coxsackievirus-Adenovirus Receptor That Limits Adenovirus Gene Transfer and Oncolysis for Human Rhabdomyosarcoma Cells
Cancer Res., April 1, 2001; 61(7): 2953 - 2960.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.