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Department of Urology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 [T. O., Y. L., R. C. P., J. Z., J. T. H.], and Division of Immunologic and Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania 19100 [J. M. B.]
In a recent paper, we reported a significant difference in coxsackie and adenovirus receptor (CAR) from several human bladder cancer cell lines that correlated with their sensitivities to adenoviral infection (Y. Li, R-C. Pong, J. M. Bergelson, M, C. Hall, A. I. Sagalowsky, C-P. Tseng, Z. Wang, and J. T. Hsieh, Cancer Res., 59: 325–330, 1999). In human prostate cancer, CAR protein is down-regulated in the highly tumorigenic PC3 cell line, which suggests that, in addition to its function as a viral receptor, CAR may have a pathophysiological role in prostate cancer progression. In this paper, we document that CAR does not merely enhance the viral sensitivity of prostate cancer cells but also acts as a tumor inhibitor for androgen-independent prostate cancer cells. Our data indicate that CAR is a potential therapeutic agent for increasing the efficacy of prostate cancer therapy.
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S. Ganesh, M. Gonzalez Edick, N. Idamakanti, M. Abramova, M. VanRoey, M. Robinson, C.-O. Yun, and K. Jooss Relaxin-Expressing, Fiber Chimeric Oncolytic Adenovirus Prolongs Survival of Tumor-Bearing Mice Cancer Res., May 1, 2007; 67(9): 4399 - 4407. [Abstract] [Full Text] [PDF]
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M. Rajecki, A. Kanerva, U.-H. Stenman, M. Tenhunen, L. Kangasniemi, M. Sarkioja, M. Y. Ala-Opas, H. Alfthan, A. Sankila, E. Rintala, et al. Treatment of prostate cancer with Ad5/3{Delta}24hCG allows non-invasive detection of the magnitude and persistence of virus replication in vivo Mol. Cancer Ther., February 1, 2007; 6(2): 742 - 751. [Abstract] [Full Text] [PDF]
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R.-C. Pong, R. Roark, J.-Y. Ou, J. Fan, J. Stanfield, E. Frenkel, A. Sagalowsky, and J.-T. Hsieh Mechanism of Increased Coxsackie and Adenovirus Receptor Gene Expression and Adenovirus Uptake by Phytoestrogen and Histone Deacetylase Inhibitor in Human Bladder Cancer Cells and the Potential Clinical Application. Cancer Res., September 1, 2006; 66(17): 8822 - 8828. [Abstract] [Full Text] [PDF]
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 J.-W. Chen, B. Zhou, Q.-C. Yu, S. J. Shin, K. Jiao, M. D. Schneider, H. S. Baldwin, and J. M. Bergelson Cardiomyocyte-Specific Deletion of the Coxsackievirus and Adenovirus Receptor Results in Hyperplasia of the Embryonic Left Ventricle and Abnormalities of Sinuatrial Valves Circ. Res., April 14, 2006; 98(7): 923 - 930. [Abstract] [Full Text] [PDF]
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M. D. Lacher, M. I. Tiirikainen, E. F. Saunier, C. Christian, M. Anders, M. Oft, A. Balmain, R. J. Akhurst, and W. M. Korn Transforming Growth Factor-{beta} Receptor Inhibition Enhances Adenoviral Infectability of Carcinoma Cells via Up-Regulation of Coxsackie and Adenovirus Receptor in Conjunction with Reversal of Epithelial-Mesenchymal Transition Cancer Res., February 1, 2006; 66(3): 1648 - 1657. [Abstract] [Full Text] [PDF]
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A. Bruning, E. Stickeler, D. Diederich, L. Walz, H. Rohleder, K. Friese, and I. B. Runnebaum Coxsackie and Adenovirus Receptor Promotes Adenocarcinoma Cell Survival and Is Expressionally Activated after Transition from Preneoplastic Precursor Lesions to Invasive Adenocarcinomas Clin. Cancer Res., June 15, 2005; 11(12): 4316 - 4320. [Abstract] [Full Text] [PDF]
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 P. Yotnda, B. Savoldo, N. Charlet-Berguerand, C. Rooney, and M. Brenner Targeted delivery of adenoviral vectors by cytotoxic T cells Blood, October 15, 2004; 104(8): 2272 - 2280. [Abstract] [Full Text] [PDF]
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M. Qin, B. Escuadro, M. Dohadwala, S. Sharma, and R. K. Batra A Novel Role for the Coxsackie Adenovirus Receptor in Mediating Tumor Formation by Lung Cancer Cells Cancer Res., September 15, 2004; 64(18): 6377 - 6380. [Abstract] [Full Text] [PDF]
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 K. J. D. A. Excoffon, A. Hruska-Hageman, M. Klotz, G. L. Traver, and J. Zabner A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth J. Cell Sci., September 1, 2004; 117(19): 4401 - 4409. [Abstract] [Full Text] [PDF]
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 V. Awasthi, G. Meinken, K. Springer, S. C. Srivastava, and P. Freimuth Biodistribution of Radioiodinated Adenovirus Fiber Protein Knob Domain after Intravenous Injection in Mice J. Virol., June 15, 2004; 78(12): 6431 - 6438. [Abstract] [Full Text] [PDF]
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W. Gu, A. Ogose, H. Kawashima, M. Ito, T. Ito, A. Matsuba, H. Kitahara, T. Hotta, K. Tokunaga, H. Hatano, et al. High-Level Expression of the Coxsackievirus and Adenovirus Receptor Messenger RNA in Osteosarcoma, Ewing's Sarcoma, and Benign Neurogenic Tumors among Musculoskeletal Tumors Clin. Cancer Res., June 1, 2004; 10(11): 3831 - 3838. [Abstract] [Full Text] [PDF]
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E. Raschperger, U. Engstrom, R. F. Pettersson, and J. Fuxe CLMP, a Novel Member of the CTX Family and a New Component of Epithelial Tight Junctions J. Biol. Chem., January 2, 2004; 279(1): 796 - 804. [Abstract] [Full Text] [PDF]
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R.-C. Pong, Y.-J. Lai, H. Chen, T. Okegawa, E. Frenkel, A. Sagalowsky, and J.-T. Hsieh Epigenetic Regulation of Coxsackie and Adenovirus Receptor (CAR) Gene Promoter in Urogenital Cancer Cells Cancer Res., December 15, 2003; 63(24): 8680 - 8686. [Abstract] [Full Text] [PDF]
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N. Belousova, N. Korokhov, V. Krendelshchikova, V. Simonenko, G. Mikheeva, P. L. Triozzi, W. A. Aldrich, P. T. Banerjee, S. D. Gillies, D. T. Curiel, et al. Genetically Targeted Adenovirus Vector Directed to CD40-Expressing Cells J. Virol., November 1, 2003; 77(21): 11367 - 11377. [Abstract] [Full Text] [PDF]
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M. Anders, C. Christian, M. McMahon, F. McCormick, and W. M. Korn Inhibition of the Raf/MEK/ERK Pathway Up-Regulates Expression of the Coxsackievirus and Adenovirus Receptor in Cancer Cells Cancer Res., May 1, 2003; 63(9): 2088 - 2095. [Abstract] [Full Text] [PDF]
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K. Sollerbrant, E. Raschperger, M. Mirza, U. Engstrom, L. Philipson, P. O. Ljungdahl, and R. F. Pettersson The Coxsackievirus and Adenovirus Receptor (CAR) Forms a Complex with the PDZ Domain-containing Protein Ligand-of-Numb Protein-X (LNX) J. Biol. Chem., February 21, 2003; 278(9): 7439 - 7444. [Abstract] [Full Text] [PDF]
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 M. Anders, R. Hansen, R.-X. Ding, K. A. Rauen, M. J. Bissell, and W. M. Korn Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor PNAS, February 18, 2003; 100(4): 1943 - 1948. [Abstract] [Full Text] [PDF]
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N. Belousova, V. Krendelchtchikova, D. T. Curiel, and V. Krasnykh Modulation of Adenovirus Vector Tropism via Incorporation of Polypeptide Ligands into the Fiber Protein J. Virol., July 29, 2002; 76(17): 8621 - 8631. [Abstract] [Full Text] [PDF]
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K. A. Rauen, D. Sudilovsky, J. L. Le, K. L. Chew, B. Hann, V. Weinberg, L. D. Schmitt, and F. McCormick Expression of the Coxsackie Adenovirus Receptor in Normal Prostate and in Primary and Metastatic Prostate Carcinoma: Potential Relevance to Gene Therapy Cancer Res., July 1, 2002; 62(13): 3812 - 3818. [Abstract] [Full Text] [PDF]
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 A. Hemminki, K. R. Zinn, B. Liu, T. R. Chaudhuri, R. A. Desmond, B. E. Rogers, M. N. Barnes, R. D. Alvarez, and D. T. Curiel In Vivo Molecular Chemotherapy and Noninvasive Imaging With an Infectivity-Enhanced Adenovirus J Natl Cancer Inst, May 15, 2002; 94(10): 741 - 749. [Abstract] [Full Text] [PDF]
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W. van't Hof and R. G. Crystal Fatty Acid Modification of the Coxsackievirus and Adenovirus Receptor J. Virol., May 15, 2002; 76(12): 6382 - 6386. [Abstract] [Full Text] [PDF]
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D. M. Shayakhmetov, Z.-Y. Li, S. Ni, and A. Lieber Targeting of Adenovirus Vectors to Tumor Cells Does Not Enable Efficient Transduction of Breast Cancer Metastases Cancer Res., February 1, 2002; 62(4): 1063 - 1068. [Abstract] [Full Text] [PDF]
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E. A. Kashentseva, T. Seki, D. T. Curiel, and I. P. Dmitriev Adenovirus Targeting to c-erbB-2 Oncoprotein by Single-Chain Antibody Fused to Trimeric Form of Adenovirus Receptor Ectodomain Cancer Res., January 1, 2002; 62(2): 609 - 616. [Abstract] [Full Text] [PDF]
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A. Kanerva, G. V. Mikheeva, V. Krasnykh, C. J. Coolidge, J. T. Lam, P. J. Mahasreshti, S. D. Barker, M. Straughn, M. N. Barnes, R. D. Alvarez, et al. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells Clin. Cancer Res., January 1, 2002; 8(1): 275 - 280. [Abstract] [Full Text] [PDF]
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C. Pramudji, S. Shimura, S. Ebara, G. Yang, J. Wang, C. Ren, Y. Yuan, S. A. Tahir, T. L. Timme, and T. C. Thompson In Situ Prostate Cancer Gene Therapy Using a Novel Adenoviral Vector Regulated by the Caveolin-1 Promoter Clin. Cancer Res., December 1, 2001; 7(12): 4272 - 4279. [Abstract] [Full Text] [PDF]
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A. Hemminki, I. Dmitriev, B. Liu, R. A. Desmond, R. Alemany, and D. T. Curiel Targeting Oncolytic Adenoviral Agents to the Epidermal Growth Factor Pathway with a Secretory Fusion Molecule Cancer Res., September 1, 2001; 61(17): 6377 - 6381. [Abstract] [Full Text] [PDF]
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T. Okegawa, R.-C. Pong, Y. Li, J. M. Bergelson, A. I. Sagalowsky, and J.-T. Hsieh The Mechanism of the Growth-inhibitory Effect of Coxsackie and Adenovirus Receptor (CAR) on Human Bladder Cancer: A Functional Analysis of CAR Protein Structure Cancer Res., September 1, 2001; 61(17): 6592 - 6600. [Abstract] [Full Text] [PDF]
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T. Tallone, S. Malin, A. Samuelsson, J. Wilbertz, M. Miyahara, K. Okamoto, L. Poellinger, L. Philipson, and S. Pettersson A mouse model for adenovirus gene delivery PNAS, July 3, 2001; 98(14): 7910 - 7915. [Abstract] [Full Text] [PDF]
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T. P. Cripe, E. J. Dunphy, A. D. Holub, A. Saini, N. H. Vasi, Y. Y. Mahller, M. H. Collins, J. D. Snyder, V. Krasnykh, D. T. Curiel, et al. Fiber Knob Modifications Overcome Low, Heterogeneous Expression of the Coxsackievirus-Adenovirus Receptor That Limits Adenovirus Gene Transfer and Oncolysis for Human Rhabdomyosarcoma Cells Cancer Res., April 1, 2001; 61(7): 2953 - 2960. [Abstract] [Full Text]
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