Cancer Research Annual Meeting 2010 EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takao, S.
Right arrow Articles by Aikou, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takao, S.
Right arrow Articles by Aikou, T.
[Cancer Research 60, 5345-5348, October 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Suppression of Metastasis by Thymidine Phosphorylase Inhibitor1

Sonshin Takao2, Shin-ichi Akiyama, Akihiro Nakajo, Hiroyoshi Yoh, Masaki Kitazono, Shoji Natsugoe, Kazutaka Miyadera, Masakazu Fukushima, Yuji Yamada and Takashi Aikou

First Department of Surgery [S. T., A. N., H. Y., M. K., S. N., T. A.], Department of Cancer Chemotherapy, Institute for Cancer Research [S-i. A.], Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan, and Taiho Pharmaceutical Co., Ltd., [K. M., M. F., Y. Y.] Saitama 357, Japan

We developed a novel inhibitor of thymidine phosphorylase (TP), 5-chloro-6-[1-(2-iminopyrrolidinyl) methyl] uracil hydrochloride (TPI), that is about 1000-fold more active than 6-amino-5-chlorouracil, one of the most potent TP inhibitors. TPI inhibited the high chemotactic motility and basement membrane invasion of KB/TP cells, a TP-positive clone transfected with Rous sarcoma virus (RSV)/TP, to the levels seen in KB/CV cells, a control clone transfected with RSV. In nude mice, oral administration of TPI suppressed not only macroscopic liver metastases of highly metastatic KB/TP cells but also the level of human ß-globin as a molecular marker of micrometastases in the livers of the mice. These findings demonstrate that TP plays a key role in the invasiveness and metastasis of TP-expressing solid tumors and suggest that TPI might be a novel antimetastatic agent for blood-borne metastasis.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
H. Lu, R. S. Klein, and E. L. Schwartz
Antiangiogenic and Antitumor Activity of 6-(2-Aminoethyl)Amino-5-Chlorouracil, a Novel Small-Molecule Inhibitor of Thymidine Phosphorylase, in Combination with the Vascular Endothelial Growth Factor-Trap
Clin. Cancer Res., August 15, 2009; 15(16): 5136 - 5144.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
E. J. Yu, Y. Lee, S. Y. Rha, T. S. Kim, H. C. Chung, B. K. Oh, W. I. Yang, S. H. Noh, and H.-C. Jeung
Angiogenic Factor Thymidine Phosphorylase Increases Cancer Cell Invasion Activity in Patients with Gastric Adenocarcinoma
Mol. Cancer Res., October 1, 2008; 6(10): 1554 - 1566.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
T. Takayama, S. Mugiya, T. Sugiyama, T. Aoki, H. Furuse, H. Liu, Y. Hirano, F. Kai, T. Ushiyama, and S. Ozono
High Levels of Thymidine Phosphorylase as an Independent Prognostic Factor in Renal Cell Carcinoma
Jpn. J. Clin. Oncol., September 1, 2006; 36(9): 564 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Kikuno, N. Moriyama-Gonda, T. Yoshino, T. Yoneda, S. Urakami, M. Terashima, M. Yoshida, H. Kishi, K. Shigeno, H. Shiina, et al.
Blockade of Paclitaxel-Induced Thymidine Phosphorylase Expression Can Accelerate Apoptosis in Human Prostate Cancer Cells
Cancer Res., October 15, 2004; 64(20): 7526 - 7532.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Nakajima, T. Gotanda, H. Uchimiya, T. Furukawa, M. Haraguchi, R. Ikeda, T. Sumizawa, H. Yoshida, and S.-i. Akiyama
Inhibition of Metastasis of Tumor Cells Overexpressing Thymidine Phosphorylase by 2-Deoxy-L-Ribose
Cancer Res., March 1, 2004; 64(5): 1794 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Seeliger, M. Guba, G. E. Koehl, A. Doenecke, M. Steinbauer, C. J. Bruns, C. Wagner, E. Frank, K.-W. Jauch, and E. K. Geissler
Blockage of 2-Deoxy-D-Ribose-Induced Angiogenesis with Rapamycin Counteracts a Thymidine Phosphorylase-Based Escape Mechanism Available for Colon Cancer under 5-Fluorouracil Therapy
Clin. Cancer Res., March 1, 2004; 10(5): 1843 - 1852.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Uchimiya, T. Furukawa, M. Okamoto, Y. Nakajima, S. Matsushita, R. Ikeda, T. Gotanda, M. Haraguchi, T. Sumizawa, M. Ono, et al.
Suppression of Thymidine Phosphorylase-mediated Angiogenesis and Tumor Growth by 2-Deoxy-L-ribose
Cancer Res., May 1, 2002; 62(10): 2834 - 2839.
[Abstract] [Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
S.-i. Aishima, K.-i. Taguchi, K. Sugimachi, Y. Asayama, H. Nishi, M. Shimada, K. Sugimachi, and M. Tsuneyoshi
The Role of Thymidine Phosphorylase and Thrombospondin-1 in Angiogenesis and Progression of Intrahepatic Cholangiocarcinoma
International Journal of Surgical Pathology, January 1, 2002; 10(1): 47 - 56.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.