Cancer Research SABCS Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wu, G.-J.
Right arrow Articles by Couch, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wu, G.-J.
Right arrow Articles by Couch, F. J.
[Cancer Research 60, 5371-5375, October 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

17q23 Amplifications in Breast Cancer Involve the PAT1, RAD51C, PS6K, and SIGMA1B Genes1

Guo-Jun Wu, Colleen S. Sinclair, John Paape, James N. Ingle, Patrick C. Roche, C. David James and Fergus J. Couch2

Departments of Laboratory Medicine and Pathology [G-J. W., C. S. S., J. P., P. C. R., C. D. J., F. J. C.], Biochemistry and Molecular Biology [F. J. C.], and Oncology [J. N. I.], Mayo Clinic and Foundation, Rochester, Minnesota 55905

Amplification of the 17q23 region occurs frequently in breast tumors. To characterize the structure of 17q23 amplicons and to identify oncogene targets associated with this alteration, we performed a copy number analysis of 87 17q23 localized expressed sequence tags in seven breast cancer cell lines. Three major regions of amplification were detected in the MCF7 and BT474 cell lines. Amplification of at least one of four known genes (PAT1, PS6K, RAD51C, and SIGMA1B) was detected in the cell lines and in 28% of 94 breast tumors. In most cases, these four genes were overexpressed when amplified, but there was a particularly good association between amplification of the SIGMA1B gene and elevated expression in tumors, which suggested a possible role for this gene in tumor progression. Our data show that this region contains at least four independent targets of amplification, which suggests that there is considerable variability in the structure of the 17q23 amplicon.




This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
M. Katsura, T. Tsuruga, O. Date, T. Yoshihara, M. Ishida, Y. Tomoda, M. Okajima, M. Takaku, H. Kurumizaka, A. Kinomura, et al.
The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction
Nucleic Acids Res., July 1, 2009; 37(12): 3959 - 3968.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. L. Yamnik, A. Digilova, D. C. Davis, Z. N. Brodt, C. J. Murphy, and M. K. Holz
S6 Kinase 1 Regulates Estrogen Receptor {alpha} in Control of Breast Cancer Cell Proliferation
J. Biol. Chem., March 6, 2009; 284(10): 6361 - 6369.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Nagaraju, S. Odate, A. Xie, and R. Scully
Differential Regulation of Short- and Long-Tract Gene Conversion between Sister Chromatids by Rad51C
Mol. Cell. Biol., November 1, 2006; 26(21): 8075 - 8086.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Wu, Z. Guo, A. Chatterjee, X. Huang, E. Rubin, F. Wu, E. Mambo, X. Chang, M. Osada, M. Sook Kim, et al.
Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer.
Cancer Res., October 15, 2006; 66(20): 9829 - 9836.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Melchor, S. Alvarez, E. Honrado, J. Palacios, A. Barroso, O. Diez, A. Osorio, and J. Benitez
The Accumulation of Specific Amplifications Characterizes Two Different Genomic Pathways of Evolution of Familial Breast Tumors
Clin. Cancer Res., December 15, 2005; 11(24): 8577 - 8584.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. K. Holz and J. Blenis
Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase
J. Biol. Chem., July 15, 2005; 280(28): 26089 - 26093.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Nessling, K. Richter, C. Schwaenen, P. Roerig, G. Wrobel, S. Wessendorf, B. Fritz, M. Bentz, H.-P. Sinn, B. Radlwimmer, et al.
Candidate Genes in Breast Cancer Revealed by Microarray-Based Comparative Genomic Hybridization of Archived Tissue
Cancer Res., January 15, 2005; 65(2): 439 - 447.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Orsetti, M. Nugoli, N. Cervera, L. Lasorsa, P. Chuchana, L. Ursule, C. Nguyen, R. Redon, S. du Manoir, C. Rodriguez, et al.
Genomic and Expression Profiling of Chromosome 17 in Breast Cancer Reveals Complex Patterns of Alterations and Novel Candidate Genes
Cancer Res., September 15, 2004; 64(18): 6453 - 6460.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W.-C. Noh, W. H. Mondesire, J. Peng, W. Jian, H. Zhang, J. Dong, G. B. Mills, M.-C. Hung, and F. Meric-Bernstam
Determinants of Rapamycin Sensitivity in Breast Cancer Cells
Clin. Cancer Res., February 1, 2004; 10(3): 1013 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Hirasawa, F. Saito-Ohara, J. Inoue, D. Aoki, N. Susumu, T. Yokoyama, S. Nozawa, J. Inazawa, and I. Imoto
Association of 17q21-q24 Gain in Ovarian Clear Cell Adenocarcinomas with Poor Prognosis and Identification of PPM1D and APPBP2 as Likely Amplification Targets
Clin. Cancer Res., June 1, 2003; 9(6): 1995 - 2004.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Wu, S. Nomoto, M. O. Hoque, T. Dracheva, M. Osada, C.-C. R. Lee, S. M. Dong, Z. Guo, N. Benoit, Y. Cohen, et al.
{Delta}Np63{alpha} and TAp63{alpha} Regulate Transcription of Genes with Distinct Biological Functions in Cancer and Development
Cancer Res., May 15, 2003; 63(10): 2351 - 2357.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Saito-Ohara, I. Imoto, J. Inoue, H. Hosoi, A. Nakagawara, T. Sugimoto, and J. Inazawa
PPM1D Is a Potential Target for 17q Gain in Neuroblastoma
Cancer Res., April 15, 2003; 63(8): 1876 - 1883.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. S. Sinclair, C. Adem, A. Naderi, C. L. Soderberg, M. Johnson, L. Wadum, V. L. Couch, T. A. Sellers, D. Schaid, J. Slezak, et al.
TBX2 Is Preferentially Amplified in BRCA1- and BRCA2-related Breast Tumors
Cancer Res., July 1, 2002; 62(13): 3587 - 3591.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. L. Andersen, O. Monni, U. Wagner, J. Kononen, M. Barlund, C. Bucher, P. Haas, A. Nocito, H. Bissig, G. Sauter, et al.
High-Throughput Copy Number Analysis of 17q23 in 3520 Tissue Specimens by Fluorescence in Situ Hybridization to Tissue Microarrays
Am. J. Pathol., July 1, 2002; 161(1): 73 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
B. C. Godthelp, W. W. Wiegant, A. van Duijn-Goedhart, O. D. Scharer, P. P. W. van Buul, R. Kanaar, and M. Z. Zdzienicka
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability
Nucleic Acids Res., May 15, 2002; 30(10): 2172 - 2182.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-Y. Masson, A. Z. Stasiak, A. Stasiak, F. E. Benson, and S. C. West
Complex formation by the human RAD51C and XRCC3 recombination repair proteins
PNAS, July 17, 2001; 98(15): 8440 - 8446.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G.-j. Wu, C. Sinclair, S. Hinson, J. N. Ingle, P. C. Roche, and F. J. Couch
Structural Analysis of the 17q22-23 Amplicon Identifies Several Independent Targets of Amplification in Breast Cancer Cell Lines and Tumors
Cancer Res., July 1, 2001; 61(13): 4951 - 4955.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Monni, M. Bärlund, S. Mousses, J. Kononen, G. Sauter, M. Heiskanen, P. Paavola, K. Avela, Y. Chen, M. L. Bittner, et al.
Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
PNAS, April 25, 2001; (2001) 91582298.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Monni, M. Barlund, S. Mousses, J. Kononen, G. Sauter, M. Heiskanen, P. Paavola, K. Avela, Y. Chen, M. L. Bittner, et al.
Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
PNAS, May 8, 2001; 98(10): 5711 - 5716.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.