Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suzuki, S.
Right arrow Articles by Gray, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, S.
Right arrow Articles by Gray, J. W.
[Cancer Research 60, 5382-5385, October 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

An Approach to Analysis of Large-Scale Correlations between Genome Changes and Clinical Endpoints in Ovarian Cancer1

Seiji Suzuki, Dan H. Moore, II, David G. Ginzinger, Tony E. Godfrey, John Barclay, Bethan Powell, Daniel Pinkel, Charles Zaloudek, Karen Lu, Gordon Mills, Andrew Berchuck and Joe W. Gray2

Cancer Center, University of California, San Francisco, California 94143-0808 [S. S., D. H. M., D. G., T. G., J. B., B. P., D. P., C. Z., J. W. G.]; MD Anderson Cancer Center, Houston Texas [K. L., G. M.]; Duke University Medical Center, Durham, North Carolina 27710 [A. B.]

This report describes analyses of associations of genome copy number abnormalities in ovarian cancers with clinical features using genome-wide graphical and analytical procedures. These studies show that tumor grade is a better indicator of the extent of genomic progression than stage, that loss of chromosome 4 occurs preferentially in high-grade tumors, and that gains of 3q26-qter, 8q24-qter, and 20q13-qter occur frequently in low-grade and low-stage tumors and thus may be early events in ovarian cancer development. In addition, loss of chromosome 16q24 and a total number of independent genome copy number aberrations >7 are associated with reduced survival duration. The association of loss of 16q24 (D16S3026) with decreased survival duration was confirmed by quantitative PCR. Regions that frequently are abnormal and associated with altered survival duration are strong candidates for higher resolution analysis and gene discovery and may be useful markers for prediction of clinical outcome.




This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
A. Astanehe, D. Arenillas, W. W. Wasserman, P. C. K. Leung, S. E. Dunn, B. R. Davies, G. B. Mills, and N. Auersperg
Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
J. Cell Sci., March 1, 2008; 121(5): 664 - 674.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
F. Lefranc, V. Facchini, and R. Kiss
Proautophagic Drugs: A Novel Means to Combat Apoptosis-Resistant Cancers, with a Special Emphasis on Glioblastomas
Oncologist, December 1, 2007; 12(12): 1395 - 1403.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. A. Patil, I. Gutgemann, J. Zhang, C. Ho, S.-T. Cheung, D. Ginzinger, R. Li, K. J. Dykema, S. So, S.-T. Fan, et al.
Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma
Carcinogenesis, December 1, 2005; 26(12): 2050 - 2057.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. M. Eder, X. Sui, D. G. Rosen, L. K Nolden, K. W. Cheng, J. P. Lahad, M. Kango-Singh, K. H. Lu, C. L. Warneke, E. N. Atkinson, et al.
Atypical PKC{iota} contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer
PNAS, August 30, 2005; 102(35): 12519 - 12524.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Raja, J. Ching, L. Xi, S. J. Hughes, R. Chang, W. Wong, W. McMillan, W. E. Gooding, K. S. McCarty Jr, M. Chestney, et al.
Technology for Automated, Rapid, and Quantitative PCR or Reverse Transcription-PCR Clinical Testing
Clin. Chem., May 1, 2005; 51(5): 882 - 890.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Hibbs, K. M. Skubitz, S. E. Pambuccian, R. C. Casey, K. M. Burleson, T. R. Oegema Jr, J. J. Thiele, S. M. Grindle, R. L. Bliss, and A. P.N. Skubitz
Differential Gene Expression in Ovarian Carcinoma: Identification of Potential Biomarkers
Am. J. Pathol., August 1, 2004; 165(2): 397 - 414.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Widschwendter, G. Jiang, C. Woods, H. M. Muller, H. Fiegl, G. Goebel, C. Marth, E. Muller-Holzner, A. G. Zeimet, P. W. Laird, et al.
DNA Hypomethylation and Ovarian Cancer Biology
Cancer Res., July 1, 2004; 64(13): 4472 - 4480.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Suzuki, K. Egami, K. Sasajima, M. Ghazizadeh, H. Shimizu, H. Watanabe, H. Hasegawa, S. Iida, T. Matsuda, Y. Okihama, et al.
Comparative Study between DNA Copy Number Aberrations Determined by Quantitative Microsatellite Analysis and Clinical Outcome in Patients with Stomach Cancer
Clin. Cancer Res., May 1, 2004; 10(9): 3013 - 3019.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Zhang, N. Yang, D. Katsaros, W. Huang, J.-W. Park, S. Fracchioli, C. Vezzani, I. A. Rigault de la Longrais, W. Yao, S. C. Rubin, et al.
The Oncogene Phosphatidylinositol 3'-Kinase Catalytic Subunit {alpha} Promotes Angiogenesis via Vascular Endothelial Growth Factor in Ovarian Carcinoma
Cancer Res., July 15, 2003; 63(14): 4225 - 4231.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. Riou, R. Saffroy, J. Comoy, M. Gross-Goupil, J.-P. Thiery, J.-F. Emile, D. Azoulay, D. Piatier-Tonneau, A. Lemoine, and B. Debuire
Investigation in Liver Tissues and Cell Lines of the Transcription of 13 Genes Mapping to the 16q24 Region That Are Frequently Deleted in Hepatocellular Carcinoma
Clin. Cancer Res., October 1, 2002; 8(10): 3178 - 3186.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Bayani, J. D. Brenton, P. F. Macgregor, B. Beheshti, M. Albert, D. Nallainathan, J. Karaskova, B. Rosen, J. Murphy, S. Laframboise, et al.
Parallel Analysis of Sporadic Primary Ovarian Carcinomas by Spectral Karyotyping, Comparative Genomic Hybridization, and Expression Microarrays
Cancer Res., June 1, 2002; 62(12): 3466 - 3476.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. R. Anderson, B. M. Brenner, H. Swede, N. Chen, W. M. Henry, J. M. Conroy, M. J. Karpenko, J.-P. Issa, J. D. Bartos, J. K. Brunelle, et al.
Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR
Cancer Res., November 1, 2001; 61(22): 8274 - 8283.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Lassus, R. Salovaara, L. A. Aaltonen, and R. Butzow
Allelic Analysis of Serous Ovarian Carcinoma Reveals Two Putative Tumor Suppressor Loci at 18q22-q23 Distal to SMAD4, SMAD2, and DCC
Am. J. Pathol., July 1, 2001; 159(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. M. Nigro, M. A. Takahashi, D. G. Ginzinger, M. Law, S. Passe, R. B. Jenkins, and K. Aldape
Detection of 1p and 19q Loss in Oligodendroglioma by Quantitative Microsatellite Analysis, a Real-Time Quantitative Polymerase Chain Reaction Assay
Am. J. Pathol., April 1, 2001; 158(4): 1253 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. B. Welsh, P. P. Zarrinkar, L. M. Sapinoso, S. G. Kern, C. A. Behling, B. J. Monk, D. J. Lockhart, R. A. Burger, and G. M. Hampton
Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer
PNAS, January 30, 2001; 98(3): 1176 - 1181.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.