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Centre for Environmental Health and Department of Biology, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
Male lacI transgenic rats were fed a diet containing 200
ppm of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP), a heterocyclic amine present in cooked meats. PhIP was found to
be a powerful prostate mutagen. After 61 days of treatment, the
lacI mutant frequency was 71 x 10-5, >20-fold higher than the spontaneous mutant
frequency of 3.2 x 10-5. The predominant
PhIP-induced mutations were G:C
T:A transversions and deletions of
G:C bp. The results directly link PhIP-induced mutations with the
earlier observation of PhIP-induced prostate cancer in rats and suggest
that exposure to dietary PhIP could be a risk factor in the incidence
of human prostate cancer.
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