Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, I. C.
Right arrow Articles by Shipp, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, I. C.
Right arrow Articles by Shipp, M. A.
[Cancer Research 60, 269-272, January 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

The Angiogenic Factor Interleukin 8 Is Induced in Non-Small Cell Lung Cancer/Pulmonary Fibroblast Cocultures1

Ian C. Anderson, Silvie E. Mari2, Ryan J. Broderick, Bernard P. Mari3 and Margaret A. Shipp4

Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115

The interactions between tumor cells and surrounding stromal elements may promote the release of angiogenic factors. Although interleukin 8 (IL-8) is a major angiogenic factor in non-small cell lung cancer (NSCLC), the stromal contribution to IL-8 expression in primary NSCLC remains to be defined. To elucidate the role of stromal elements in NSCLC IL-8 production, normal pulmonary fibroblasts were cocultured with six representative NSCLC lines in direct and transwell assays. IL-8 transcripts and protein were consistently induced in fibroblasts and a subset of NSCLCs as a consequence of tumor/stromal coculture. In these cocultures, IL-8 was induced by IL-1{alpha} and an additional, as yet unidentified, soluble factor. These data underscore the importance of tumor/stromal interaction in the production of angiogenic peptides such as IL-8 in NSCLC.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
C.-Q. Zhu, S. N. Popova, E. R. S. Brown, D. Barsyte-Lovejoy, R. Navab, W. Shih, M. Li, M. Lu, I. Jurisica, L. Z. Penn, et al.
Integrin {alpha}11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells
PNAS, July 10, 2007; 104(28): 11754 - 11759.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. R. McClelland, S. L. Carskadon, L. Zhao, E. S. White, D. G. Beer, M. B. Orringer, A. Pickens, A. C. Chang, and D. A. Arenberg
Diversity of the Angiogenic Phenotype in Non-Small Cell Lung Cancer
Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 343 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P.-L. Yao, Y.-C. Lin, C.-H. Wang, Y.-C. Huang, W.-Y. Liao, S.-S. Wang, J. J. W. Chen, and P.-C. Yang
Autocrine and Paracrine Regulation of Interleukin-8 Expression in Lung Cancer Cells
Am. J. Respir. Cell Mol. Biol., June 1, 2005; 32(6): 540 - 547.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. J.W. Chen, Y.-C. Lin, P.-L. Yao, A. Yuan, H.-Y. Chen, C.-T. Shun, M.-F. Tsai, C.-H. Chen, and P.-C. Yang
Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression
J. Clin. Oncol., February 10, 2005; 23(5): 953 - 964.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Sato, N. Maehara, and M. Goggins
Gene Expression Profiling of Tumor-Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts
Cancer Res., October 1, 2004; 64(19): 6950 - 6956.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Pold, L. X. Zhu, S. Sharma, M. D. Burdick, Y. Lin, P. P. N. Lee, A. Pold, J. Luo, K. Krysan, M. Dohadwala, et al.
Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer
Cancer Res., March 1, 2004; 64(5): 1853 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. J.W. Chen, P.-L. Yao, A. Yuan, T.-M. Hong, C.-T. Shun, M.-L. Kuo, Y.-C. Lee, and P.-C. Yang
Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer
Clin. Cancer Res., February 1, 2003; 9(2): 729 - 737.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. S. White, K. R. Flaherty, S. Carskadon, A. Brant, M. D. Iannettoni, J. Yee, M. B. Orringer, and D. A. Arenberg
Macrophage Migration Inhibitory Factor and CXC Chemokine Expression in Non-Small Cell Lung Cancer: Role in Angiogenesis and Prognosis
Clin. Cancer Res., February 1, 2003; 9(2): 853 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. S. White, S. R. B. Strom, N. L. Wys, and D. A. Arenberg
Non-Small Cell Lung Cancer Cells Induce Monocytes to Increase Expression of Angiogenic Activity
J. Immunol., June 15, 2001; 166(12): 7549 - 7555.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2000 by the American Association for Cancer Research.