This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Anderson, I. C. Articles by Shipp, M. A. Search for Related Content PubMed PubMed Citation Articles by Anderson, I. C. Articles by Shipp, M. A.

The Angiogenic Factor Interleukin 8 Is Induced in Non-Small Cell Lung Cancer/Pulmonary Fibroblast Cocultures¹

Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115

The interactions between tumor cells and surrounding stromal elements may promote the release of angiogenic factors. Although interleukin 8 (IL-8) is a major angiogenic factor in non-small cell lung cancer (NSCLC), the stromal contribution to IL-8 expression in primary NSCLC remains to be defined. To elucidate the role of stromal elements in NSCLC IL-8 production, normal pulmonary fibroblasts were cocultured with six representative NSCLC lines in direct and transwell assays. IL-8 transcripts and protein were consistently induced in fibroblasts and a subset of NSCLCs as a consequence of tumor/stromal coculture. In these cocultures, IL-8 was induced by IL-1 and an additional, as yet unidentified, soluble factor. These data underscore the importance of tumor/stromal interaction in the production of angiogenic peptides such as IL-8 in NSCLC.

This article has been cited by other articles:

				U. Grandel, D. Heygster, U. Sibelius, L. Fink, S. Sigel, W. Seeger, F. Grimminger, and K. Hattar Amplification of Lipopolysaccharide-Induced Cytokine Synthesis in Non-Small Cell Lung Cancer/Neutrophil Cocultures Mol. Cancer Res., October 1, 2009; 7(10): 1729 - 1735. [Abstract] [Full Text] [PDF]

				C.-Y. Lee, H.-F. Sher, H.-W. Chen, C.-C. Liu, C.-H. Chen, C.-S. Lin, P.-C. Yang, H.-S. Tsay, and J. J.W. Chen Anticancer effects of tanshinone I in human non-small cell lung cancer Mol. Cancer Ther., November 1, 2008; 7(11): 3527 - 3538. [Abstract] [Full Text] [PDF]

				C.-Q. Zhu, S. N. Popova, E. R. S. Brown, D. Barsyte-Lovejoy, R. Navab, W. Shih, M. Li, M. Lu, I. Jurisica, L. Z. Penn, et al. Integrin {alpha}11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells PNAS, July 10, 2007; 104(28): 11754 - 11759. [Abstract] [Full Text] [PDF]

				M. R. McClelland, S. L. Carskadon, L. Zhao, E. S. White, D. G. Beer, M. B. Orringer, A. Pickens, A. C. Chang, and D. A. Arenberg Diversity of the Angiogenic Phenotype in Non-Small Cell Lung Cancer Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 343 - 350. [Abstract] [Full Text] [PDF]

				P.-L. Yao, Y.-C. Lin, C.-H. Wang, Y.-C. Huang, W.-Y. Liao, S.-S. Wang, J. J. W. Chen, and P.-C. Yang Autocrine and Paracrine Regulation of Interleukin-8 Expression in Lung Cancer Cells Am. J. Respir. Cell Mol. Biol., June 1, 2005; 32(6): 540 - 547. [Abstract] [Full Text] [PDF]

				J. J.W. Chen, Y.-C. Lin, P.-L. Yao, A. Yuan, H.-Y. Chen, C.-T. Shun, M.-F. Tsai, C.-H. Chen, and P.-C. Yang Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression J. Clin. Oncol., February 10, 2005; 23(5): 953 - 964. [Abstract] [Full Text] [PDF]

				N. Sato, N. Maehara, and M. Goggins Gene Expression Profiling of Tumor-Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts Cancer Res., October 1, 2004; 64(19): 6950 - 6956. [Abstract] [Full Text] [PDF]

				M. Pold, L. X. Zhu, S. Sharma, M. D. Burdick, Y. Lin, P. P. N. Lee, A. Pold, J. Luo, K. Krysan, M. Dohadwala, et al. Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer Cancer Res., March 1, 2004; 64(5): 1853 - 1860. [Abstract] [Full Text] [PDF]

				J. J.W. Chen, P.-L. Yao, A. Yuan, T.-M. Hong, C.-T. Shun, M.-L. Kuo, Y.-C. Lee, and P.-C. Yang Up-Regulation of Tumor Interleukin-8 Expression by Infiltrating Macrophages: Its Correlation with Tumor Angiogenesis and Patient Survival in Non-Small Cell Lung Cancer Clin. Cancer Res., February 1, 2003; 9(2): 729 - 737. [Abstract] [Full Text] [PDF]

				E. S. White, K. R. Flaherty, S. Carskadon, A. Brant, M. D. Iannettoni, J. Yee, M. B. Orringer, and D. A. Arenberg Macrophage Migration Inhibitory Factor and CXC Chemokine Expression in Non-Small Cell Lung Cancer: Role in Angiogenesis and Prognosis Clin. Cancer Res., February 1, 2003; 9(2): 853 - 860. [Abstract] [Full Text] [PDF]

				E. S. White, S. R. B. Strom, N. L. Wys, and D. A. Arenberg Non-Small Cell Lung Cancer Cells Induce Monocytes to Increase Expression of Angiogenic Activity J. Immunol., June 15, 2001; 166(12): 7549 - 7555. [Abstract] [Full Text] [PDF]