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[Cancer Research 60, 5608-5611, October 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Chromosomal Instability in Unirradiated Cells Induced in Vivo by a Bystander Effect of Ionizing Radiation1

Gwyneth E. Watson, Sally A. Lorimore2, Denise A. Macdonald and Eric G. Wright3

Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD, United Kingdom

Using a bone marrow transplantation protocol in which we transplanted a mixture of irradiated and nonirradiated bone marrow cells that were distinguishable by a cytogenetic marker, we have demonstrated chromosomal instability in the progeny of nonirradiated hemopoietic stem cells. This first demonstration of a link between a bystander effect of ionizing radiation and the induction of genomic instability in vivo clearly poses a major challenge to current views of the mechanisms of radiation-induced DNA damage with mechanistic implications for the health consequences of radiation exposure particularly in the context of the induction of malignancy.




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