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[Cancer Research 60, 5621-5624, October 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Association between Survival after Treatment for Breast Cancer and Glutathione S-Transferase P1 Ile105Val Polymorphism1

Carol Sweeney2, Gail Y. McClure, Manal Y. Fares, Angie Stone, Brian F. Coles, Patricia A. Thompson, Soheila Korourian, Laura F. Hutchins, Fred F. Kadlubar and Christine B. Ambrosone

National Center for Toxicological Research, Jefferson, Arkansas 72079 [C. S., G. Y. M., A. S., B. F. C., F. F. K., C. B. A.]; Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 [C. S., G. Y. M., M. Y. F., S. K., L. F. H., C. B. A.]; and Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 [P. A. T.]

A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment agents and in outcomes of therapy. We evaluated survival according to GSTP1 genotype among women (n = 240) treated for breast cancer. Women with the low-activity Val/Val genotype had better survival. Compared with Ile/Ile, hazard ratios for overall survival were 0.8 (95% confidence interval, 0.5–1.3) for Ile/Val and 0.3 (95% confidence interval, 0.1–1.0) for Val/Val (P for trend = 0.04). Inherited metabolic variability may influence treatment outcomes.




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Copyright © 2000 by the American Association for Cancer Research.