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[Cancer Research 60, 5625-5629, October 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Scavenging of Reactive Oxygen Species Leads to Diminished Peritoneal Tumor Recurrence

Marie-Elma E. van Rossen1, Wim Sluiter, Fred Bonthuis, Hans Jeekel, Richard L. Marquet and Casper H. J. van Eijck

Laboratories for Experimental Surgery and Oncology [M-E. E. v. R., F. B., H. J., R. L. M., C. H. J. v. E.] and Biochemistry [W. S.], Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands

Previously, we demonstrated that RBCs inhibit the recurrence of perioperatively spilled tumor cells. The aim of this study was to identify on which RBC component(s) the inhibitory effect is based. By using a cell-seeding model in rats, the effect of RBC-related antioxidant scavengers [hemoglobin, catalase, and superoxide dismutase (SOD)] on peritoneal tumor recurrence was investigated. i.p. injection of hemoglobin caused 45% more tumor load (P < 0.0001). At least 40% inhibition of tumor recurrence was achieved with the use of catalase or SOD (P < 0.05). Combining SOD and catalase did not lead to additional inhibition of tumor recurrence. Inhibition of the overwhelming oxidative potential after surgical peritoneal trauma with the use of scavengers may lead to interesting new approaches for diminishing peritoneal tumor recurrence.




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F. Okada, M. Kobayashi, H. Tanaka, T. Kobayashi, H. Tazawa, Y. Iuchi, K. Onuma, M. Hosokawa, M. C. Dinauer, and N. H. Hunt
The Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Derived Reactive Oxygen Species in the Acquisition of Metastatic Ability of Tumor Cells
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[Abstract] [Full Text] [PDF]


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Copyright © 2000 by the American Association for Cancer Research.