Cancer Research Cancer Epigenetics Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shimura, S.
Right arrow Articles by Thompson, T. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shimura, S.
Right arrow Articles by Thompson, T. C.
[Cancer Research 60, 5857-5861, October 15, 2000]
© 2000 American Association for Cancer Research

Tumor Biology

Reduced Infiltration of Tumor-associated Macrophages in Human Prostate Cancer: Association with Cancer Progression1

Satoru Shimura, Guang Yang, Shin Ebara, Thomas M. Wheeler, Anna Frolov and Timothy C. Thompson2

Scott Department of Urology [S. S., G. Y., S. E., A. F., T. C. T.] and Departments of Pathology [T. M. W.], Cell Biology [T. C. T.], and Radiology [T. C. T.], Baylor College of Medicine, Houston, Texas 77030

Tumor-associated macrophages (TAMs) are highly active immune effector cells that may either positively or negatively regulate the growth of various malignant cells, depending on the biological context. However, the role of TAMs in human prostate cancer progression is unclear. TAMs were immunohistochemically labeled using a monoclonal (CD68) antibody in radical prostatectomy specimens derived from 81 prostate cancer patients. CD68-positive cells were counted with the aid of a microscope and expressed as macrophage index (M{phi}I), including TAMs/mm2 total tumor tissue (M{phi}Itotal), TAMs/mm2 tumor stroma (M{phi}Istroma), and TAMs/mm2 cancer cell area (M{phi}Icancer). M{phi}Is were analyzed in association with patients’ clinical and pathological stage, recurrence status, and histological grade of the cancer. There were significant inverse relationships between M{phi}Itotal and M{phi}Istroma and clinical stage (P = 0.016 and P = 0.006, respectively). Reduced M{phi}Itotal was also associated with the presence of positive lymph nodes (P = 0.010). Interestingly, although all of the M{phi}Is differed between Gleason score groups, only M{phi}Icancer was positively associated with Gleason score. Univariate analysis of M{phi}Itotal and multivariate analysis of M{phi}Itotal with specific pathological markers revealed that M{phi}Itotal was an independent predictor for disease-free survival after surgery (Cox proportional hazard model, P = 0.044 and P = 0.007, respectively). For patients with high M{phi}Itotal (>=185.8, the mean M{phi}Itotal value), the disease-free probability 5 years after surgery was 0.75, which was significantly higher than for those with low M{phi}Itotal (0.31, P = 0.0008). Additional immunohistochemical studies that evaluated cytotoxicity-related biomarkers in stroma-associated mononuclear cells suggested reduced functional activities in highly aggressive prostate cancer compared with less aggressive disease. Our results indicate that reduced M{phi}Itotal is a novel prognostic marker for prostate cancer.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
J. A. Garcia, E. A. Klein, C. Magi-Galluzzi, P. Elson, P. Triozzi, and R. Dreicer
Clinical and Biological Effects of Neoadjuvant Sargramostim and Thalidomide in Patients with Locally Advanced Prostate Carcinoma
Clin. Cancer Res., May 15, 2008; 14(10): 3052 - 3059.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. R. Perri, B. Annabi, and J. Galipeau
Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton
FASEB J, December 1, 2007; 21(14): 3928 - 3936.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Xu, F. Wang, M. Di, Q. Huang, M. Wang, H. Hu, Y. Jin, J. Dong, and M. Lai
Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma
Clin. Cancer Res., September 1, 2007; 13(17): 5082 - 5088.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. T. Lee, J. H. Hong, C. Kwak, J. Woo, V. Liu, C. Lee, and I. Y. Kim
Effect of Dominant Negative Transforming Growth Factor-{beta} Receptor Type II on Cytotoxic Activity of RAW 264.7, a Murine Macrophage Cell Line
Cancer Res., July 15, 2007; 67(14): 6717 - 6724.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. Hoffmann, W. Bayer, T. Grunwald, and O. Wildner
Intratumoral expression of respiratory syncytial virus fusion protein in combination with cytokines encoded by adenoviral vectors as in situ tumor vaccine for colorectal cancer
Mol. Cancer Ther., July 1, 2007; 6(7): 1942 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Forssell, A. Oberg, M. L. Henriksson, R. Stenling, A. Jung, and R. Palmqvist
High Macrophage Infiltration along the Tumor Front Correlates with Improved Survival in Colon Cancer
Clin. Cancer Res., March 1, 2007; 13(5): 1472 - 1479.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. J. Nesslinger, R. A. Sahota, B. Stone, K. Johnson, N. Chima, C. King, D. Rasmussen, D. Bishop, P. S. Rennie, M. Gleave, et al.
Standard Treatments Induce Antigen-Specific Immune Responses in Prostate Cancer
Clin. Cancer Res., March 1, 2007; 13(5): 1493 - 1502.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen
Monocyte/macrophage infiltration in tumors: modulators of angiogenesis
J. Leukoc. Biol., December 1, 2006; 80(6): 1183 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. J. Welsh, R. H. Green, D. Richardson, D. A. Waller, K. J. O'Byrne, and P. Bradding
Macrophage and Mast-Cell Invasion of Tumor Cell Islets Confers a Marked Survival Advantage in Non-Small-Cell Lung Cancer
J. Clin. Oncol., December 10, 2005; 23(35): 8959 - 8967.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
W. S. Webster, E. J. Small, B. I. Rini, and E. D. Kwon
Prostate Cancer Immunology: Biology, Therapeutics, and Challenges
J. Clin. Oncol., November 10, 2005; 23(32): 8262 - 8269.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Yokoigawa, N. Takeuchi, M. Toda, M. Inoue, M. Kaibori, H. Yanagida, H. Tanaka, T. Ogura, H. Takada, T. Okumura, et al.
Enhanced Production of Interleukin 6 in Peripheral Blood Monocytes Stimulated with Mucins Secreted into the Bloodstream
Clin. Cancer Res., September 1, 2005; 11(17): 6127 - 6132.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-P. Herbeuval, E. Lelievre, C. Lambert, M. Dy, and C. Genin
Recruitment of STAT3 for Production of IL-10 by Colon Carcinoma Cells Induced by Macrophage-Derived IL-6
J. Immunol., April 1, 2004; 172(7): 4630 - 4636.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Yang, J. Addai, W.-h. Tian, A. Frolov, T. M. Wheeler, and T. C. Thompson
Reduced Infiltration of Class A Scavenger Receptor Positive Antigen-Presenting Cells Is Associated with Prostate Cancer Progression
Cancer Res., March 15, 2004; 64(6): 2076 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Taverna, H. Moher, D. Crowley, L. Borsig, A. Varki, and R. O. Hynes
Increased primary tumor growth in mice null for {beta}3- or {beta}3/{beta}5-integrins or selectins
PNAS, January 20, 2004; 101(3): 763 - 768.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Satoh, T. Saika, S. Ebara, N. Kusaka, T. L. Timme, G. Yang, J. Wang, V. Mouraviev, G. Cao, E. M. A. Fattah, et al.
Macrophages Transduced with an Adenoviral Vector Expressing Interleukin 12 Suppress Tumor Growth and Metastasis in a Preclinical Metastatic Prostate Cancer Model
Cancer Res., November 15, 2003; 63(22): 7853 - 7860.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. H. Seppala, T. Ikonen, V. Autio, A. Rokman, N. Mononen, M. P. Matikainen, T. L. J. Tammela, and J. Schleutker
Germ-Line Alterations in MSR1 Gene and Prostate Cancer Risk
Clin. Cancer Res., November 1, 2003; 9(14): 5252 - 5256.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Zhang, W. Lu, and Z. Dong
Tumor-infiltrating Macrophages Are Involved in Suppressing Growth and Metastasis of Human Prostate Cancer Cells by INF-{beta} Gene Therapy in Nude Mice
Clin. Cancer Res., September 1, 2002; 8(9): 2942 - 2951.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Y. Liu and L. D. True
Characterization of Prostate Cell Types by CD Cell Surface Molecules
Am. J. Pathol., January 1, 2002; 160(1): 37 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Mercader, B. K. Bodner, M. T. Moser, P. S. Kwon, E. S. Y. Park, R. G. Manecke, T. M. Ellis, E. M. Wojcik, D. Yang, R. C. Flanigan, et al.
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
PNAS, December 4, 2001; 98(25): 14565 - 14570.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Schumacher, W. Haensch, C. Röefzaad, and P. M. Schlag
Prognostic Significance of Activated CD8+ T Cell Infiltrations within Esophageal Carcinomas
Cancer Res., May 1, 2001; 61(10): 3932 - 3936.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.