Cancer Research Meeting Calendar Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gao, H.
Right arrow Articles by Snapka, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, H.
Right arrow Articles by Snapka, R. M.
[Cancer Research 60, 5937-5940, November 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Chloroquinoxaline Sulfonamide (NSC 339004) Is a Topoisomerase II{alpha}/ß Poison1

Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen and Robert M. Snapka2

Departments of Radiology [H. G., E. F. Y., R. M. S.]; Molecular Virology, Immunology and Medical Genetics [H. G., R. M. S.]; College of Medicine [H. G., E. F. Y., R. M. S., K. K. C.]; and College of Pharmacy [K. K. C.], Ohio State University, Columbus, Ohio 43210, and Abbott Laboratories, Abbott Park, Illinois 60064 [L. L. S.]

Chloroquinoxaline sulfonamide (chlorosulfaquinoxaline, CQS, NSC 339004) is active against murine and human solid tumors. On the basis of its structural similarity to the topoisomerase IIß-specific drug XK469, CQS was tested and found to be both a topoisomerase-II{alpha} and a topoisomerase-IIß poison. Topoisomerase II poisoning by CQS is essentially undetectable in assays using the common protein denaturant SDS, but easily detectable with strong chaotropic protein denaturants. The finding that detection of topoisomerase poisoning can be so dependent on the protein denaturant used in the assay has implications for drug discovery efforts and for our understanding of topoisomerase poisons.




This article has been cited by other articles:


Home page
 Mol. Pharmacol.Home page
H. Gao, E. F. Yamasaki, K. K. Chan, L. L. Shen, and R. M. Snapka
DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS
Mol. Pharmacol., June 1, 2003; 63(6): 1382 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-C. Huang, H. Gao, E. F. Yamasaki, D. R. Grabowski, S. Liu, L. L. Shen, K. K. Chan, R. Ganapathi, and R. M. Snapka
Topoisomerase II Poisoning by ICRF-193
J. Biol. Chem., November 21, 2001; 276(48): 44488 - 44494.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.