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[Cancer Research 60, 6227-6229, November 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

t(9;11)(p22;p15) in Acute Myeloid Leukemia Results in a Fusion between NUP98 and the Gene Encoding Transcriptional Coactivators p52 and p75-Lens Epithelium-derived Growth Factor (LEDGF)1

Harish G. Ahuja2, Jianming Hong, Peter D. Aplan, Lucene Tcheurekdjian, Stephen J. Forman and Marilyn L. Slovak

Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263 [H. G. A., J. H.]; Division of Clinical Sciences, National Cancer Institute, Gaithersburg, Maryland 20877 [P. D. A.]; and Departments of Hematology and Bone Marrow Transplantation [S. J. F.] and Cytogenetics [L. T., M. L. S.], City of Hope, National Medical Center, Duarte, California 91010

A t(9;11)(p22;p15) chromosomal translocation was identified in an adult patient with de novo acute myelogenous leukemia. Fluorescence in situ hybridization and Southern blot analysis mapped the 11p15 breakpoint to the NUP98 gene. Using 3' rapid amplification of cDNA ends, we have identified a chimeric mRNA that fused the NUP98 FXFG repeats in frame to the COOH-terminal portion of the gene encoding the transcriptional coactivators p52 and p75, also known as lens epithelium-derived growth factor (LEDGF). As expected, both NUP98-p52 and NUP98-p75 (LEDGF) chimeric mRNAs were detected by reverse transcription-PCR; however, the reciprocal p52/p75 (LEDGF)-NUP98 fusion mRNA was not detected. Our results demonstrate that this is the most 5' NUP98 fusion reported and reveal a previously unrecognized genetic target, the gene encoding p52/p75 (LEDGF).




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