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[Cancer Research 60, 6298-6302, November 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Thymidine Phosphorylase Induces Carcinoma Cell Oxidative Stress and Promotes Secretion of Angiogenic Factors1

Nicholas S. Brown, Adam Jones, Chisato Fujiyama, Adrian L. Harris and Roy Bicknell2

Molecular Angiogenesis Laboratory [N. S. B., R. B.] and Molecular Oncology Group [A. J., C. F., A. L. H.], Imperial Cancer Research Fund, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, and Department of Urology, Churchill Hospital, Oxford OX3 7LJ [A. J.], United Kingdom

Thymidine phosphorylase (TP) (E.C. 2.4.2.4), also known as platelet-derived endothelial cell growth factor, is a potent angiogenic factor. The expression of TP correlates with poor prognosis in a range of tumor types. 2-Deoxy-D-ribose-1-phosphate, a product of thymidine catabolism by TP, is a strongly reducing sugar that generates oxygen radical species during the early stages of protein glycation. We show that thymidine induces oxidative stress in TP-overexpressing carcinoma cells, promoting secretion of the stress-induced angiogenic factors vascular endothelial growth factor and interleukin-8, and inducing matrix metalloproteinase-1. Our findings outline a putative mechanism for TP-induced angiogenesis and identify novel targets for intervention.




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