This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Xia, Y. Articles by Li, J. Search for Related Content PubMed PubMed Citation Articles by Xia, Y. Articles by Li, J.

The Oncogenic Potential of the High Mobility Group Box Protein Sox3¹

Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037 [Y. X., P. K. V., J. L.], and Wellcome/CRC Institute, Cambridge CB2 1QR, United Kingdom [N. P.]

Sox proteins belong to the superfamily of high mobility group (HMG) proteins. Sox3 is expressed predominantly in the immature neuroepithelium. Ectopic expression of Sox3 causes oncogenic transformation of chicken embryo fibroblasts (CEFs). The oncogenicity of Sox3 is correlated with nuclear localization and transcriptional regulatory activity; mutants containing deletions in the HMG box or the transactivation domain fail to induce foci of transformation. These observations suggest that Sox proteins can induce aberrant cell growth and strengthen the link of HMG proteins to oncogenesis.

This article has been cited by other articles:

				Y. Chen, L. Shi, L. Zhang, R. Li, J. Liang, W. Yu, L. Sun, X. Yang, Y. Wang, Y. Zhang, et al. The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer J. Biol. Chem., June 27, 2008; 283(26): 17969 - 17978. [Abstract] [Full Text] [PDF]

				Y. Du, S. E. Spence, N. A. Jenkins, and N. G. Copeland Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis Blood, October 1, 2005; 106(7): 2498 - 2505. [Abstract] [Full Text] [PDF]

				R. S. Friedman, C. S. Bangur, E. J. Zasloff, L. Fan, T. Wang, Y. Watanabe, and M. Kalos Molecular and Immunological Evaluation of the Transcription Factor SOX-4 as a Lung Tumor Vaccine Antigen J. Immunol., March 1, 2004; 172(5): 3319 - 3327. [Abstract] [Full Text] [PDF]

				R. Kim, A. Trubetskoy, T. Suzuki, N. A. Jenkins, N. G. Copeland, and J. Lenz Genome-Based Identification of Cancer Genes by Proviral Tagging in Mouse Retrovirus-Induced T-Cell Lymphomas J. Virol., February 1, 2003; 77(3): 2056 - 2062. [Abstract] [Full Text] [PDF]

				W. Takash, J. Canizares, N. Bonneaud, F. Poulat, M.-G. Mattei, P. Jay, and P. Berta SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling Nucleic Acids Res., November 1, 2001; 29(21): 4274 - 4283. [Abstract] [Full Text] [PDF]