Cancer Research Cell Death Mechanisms and Cancer Therapy EMT and Cancer Progression and Treatment
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liao, F.
Right arrow Articles by Bohlen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liao, F.
Right arrow Articles by Bohlen, P.
[Cancer Research 60, 6805-6810, December 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Monoclonal Antibody to Vascular Endothelial-cadherin Is a Potent Inhibitor of Angiogenesis, Tumor Growth, and Metastasis1

Fang Liao, Yiwen Li, William O’Connor, Lucia Zanetta, Rajiv Bassi, Angel Santiago, Jay Overholser, Andrea Hooper, Paolo Mignatti, Elisabetta Dejana, Daniel J. Hicklin2 and Peter Bohlen

Departments of Immunology and Molecular and Cell Biology and Research, ImClone Systems Incorporated, New York, New York 10014 [F. L., Y. L., W. O., R. B., A. S., J. O., A. H., D. J. H., P. B.]; Instituto di Ricerche Farmacologiche, Mario Negri, 20157 Milan, Italy [L. Z., E. D.]; and Departments of Surgery and Cell Biology, New York University School of Medicine, New York, New York 10016 [P. M.]

Vascular endothelial-cadherin (VE-cad) is an endothelial cell-specific adhesion molecule that is crucial for proper assembly of vascular tubes. Here we show that a monoclonal antibody (BV13) directed to the extracellular region of VE-cad inhibits formation of adherens junctions and capillary-like structures by endothelial cells and blocks angiogenesis in the mouse cornea and in Matrigel plugs in vivo. Systemic administration of BV13 markedly decreases the growth of s.c. Lewis lung or human A431 epidermoid tumors and strongly suppresses the growth of Lewis lung metastases. These data demonstrate that VE-cad is essential for postnatal angiogenesis and thus validate VE-cad as a novel target for antiangiogenesis agents.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
M. Labelle, H. J. Schnittler, D. E. Aust, K. Friedrich, G. Baretton, D. Vestweber, and G. Breier
Vascular Endothelial Cadherin Promotes Breast Cancer Progression via Transforming Growth Factor {beta} Signaling
Cancer Res., March 1, 2008; 68(5): 1388 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
D. Vestweber
VE-Cadherin: The Major Endothelial Adhesion Molecule Controlling Cellular Junctions and Blood Vessel Formation
Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 223 - 232.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
I. Fishel, A. Kaufman, and E. Ruppin
Meta-analysis of gene expression data: a predictor-based approach
Bioinformatics, July 1, 2007; 23(13): 1599 - 1606.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Nicoli, D. Ribatti, F. Cotelli, and M. Presta
Mammalian Tumor Xenografts Induce Neovascularization in Zebrafish Embryos
Cancer Res., April 1, 2007; 67(7): 2927 - 2931.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
N. Kogata, Y. Arai, J. T. Pearson, K. Hashimoto, K. Hidaka, T. Koyama, S. Somekawa, Y. Nakaoka, M. Ogawa, R. H. Adams, et al.
Cardiac Ischemia Activates Vascular Endothelial Cadherin Promoter in Both Preexisting Vascular Cells and Bone Marrow Cells Involved in Neovascularization
Circ. Res., April 14, 2006; 98(7): 897 - 904.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. Xiao, J. Garner, K. M. Buckley, P. A. Vincent, C. M. Chiasson, E. Dejana, V. Faundez, and A. P. Kowalczyk
p120-Catenin Regulates Clathrin-dependent Endocytosis of VE-Cadherin
Mol. Biol. Cell, November 1, 2005; 16(11): 5141 - 5151.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Lamagna, K. M. Hodivala-Dilke, B. A. Imhof, and M. Aurrand-Lions
Antibody against Junctional Adhesion Molecule-C Inhibits Angiogenesis and Tumor Growth
Cancer Res., July 1, 2005; 65(13): 5703 - 5710.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. May, J. F. Doody, R. Abdullah, P. Balderes, X. Xu, C. P. Chen, Z. Zhu, L. Shapiro, P. Kussie, D. J. Hicklin, et al.
Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature
Blood, June 1, 2005; 105(11): 4337 - 4344.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. V. Crosby, P. A. Fleming, W. S. Argraves, M. Corada, L. Zanetta, E. Dejana, and C. J. Drake
VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly
Blood, April 1, 2005; 105(7): 2771 - 2776.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Sengupta, S. Caballero, R. N. Mames, A. M. Timmers, D. Saban, and M. B. Grant
Preventing Stem Cell Incorporation into Choroidal Neovascularization by Targeting Homing and Attachment Factors
Invest. Ophthalmol. Vis. Sci., January 1, 2005; 46(1): 343 - 348.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. S. Parker, P. Argani, B. P. Cook, H. Liangfeng, S. D. Chartrand, M. Zhang, S. Saha, A. Bardelli, Y. Jiang, T. B. St. Martin, et al.
Alterations in Vascular Gene Expression in Invasive Breast Carcinoma
Cancer Res., November 1, 2004; 64(21): 7857 - 7866.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
S. Weis, J. Cui, L. Barnes, and D. Cheresh
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
J. Cell Biol., October 25, 2004; 167(2): 223 - 229.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. P. Lefter, M. Sunamura, T. Furukawa, K. Takeda, N. Kotobuki, M. Oshimura, S. Matsuno, and A. Horii
Inserting Chromosome 18 into Pancreatic Cancer Cells Switches Them to a Dormant Metastatic Phenotype
Clin. Cancer Res., October 15, 2003; 9(13): 5044 - 5052.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. M. Nelson and C. S. Chen
VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension
J. Cell Sci., September 1, 2003; 116(17): 3571 - 3581.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. C. Calkins, B. L. Hoepner, C. M. Law, M. R. Novak, S. V. Setzer, M. Hatzfeld, and A. P. Kowalczyk
The Armadillo Family Protein p0071 Is a VE-cadherin- and Desmoplakin-binding Protein
J. Biol. Chem., January 10, 2003; 278(3): 1774 - 1783.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. Venkiteswaran, K. Xiao, S. Summers, C. C. Calkins, P. A. Vincent, K. Pumiglia, and A. P. Kowalczyk
Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta -catenin
Am J Physiol Cell Physiol, September 1, 2002; 283(3): C811 - C821.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Corada, L. Zanetta, F. Orsenigo, F. Breviario, M. G. Lampugnani, S. Bernasconi, F. Liao, D. J. Hicklin, P. Bohlen, and E. Dejana
A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
Blood, July 18, 2002; 100(3): 905 - 911.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
Y. Mishima, Y. Matsumoto-Mishima, Y. Terui, M. Katsuyama, M. Yamada, M. Mori, Y. Ishizaka, K. Ikeda, J.-i. Watanabe, N. Mizunuma, et al.
Leukemic Cell-Surface CD13/Aminopeptidase N and Resistance to Apoptosis Mediated by Endothelial Cells
J Natl Cancer Inst, July 3, 2002; 94(13): 1020 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Y. Li, M.-N. Wang, H. Li, K. D. King, R. Bassi, H. Sun, A. Santiago, A. T. Hooper, P. Bohlen, and D. J. Hicklin
Active Immunization Against the Vascular Endothelial Growth Factor Receptor flk1 Inhibits Tumor Angiogenesis and Metastasis
J. Exp. Med., June 17, 2002; 195(12): 1575 - 1584.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Liao, J. F. Doody, J. Overholser, B. Finnerty, R. Bassi, Y. Wu, E. Dejana, P. Kussie, P. Bohlen, and D. J. Hicklin
Selective Targeting of Angiogenic Tumor Vasculature by Vascular Endothelial-cadherin Antibody Inhibits Tumor Growth without Affecting Vascular Permeability
Cancer Res., May 1, 2002; 62(9): 2567 - 2575.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. G. Lampugnani, A. Zanetti, F. Breviario, G. Balconi, F. Orsenigo, M. Corada, R. Spagnuolo, M. Betson, V. Braga, and E. Dejana
VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam
Mol. Biol. Cell, April 1, 2002; 13(4): 1175 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. van Wetering, J. D. van Buul, S. Quik, F. P. J. Mul, E. C. Anthony, J.-P. t. Klooster, J. G. Collard, and P. L. Hordijk
Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells
J. Cell Sci., January 5, 2002; 115(9): 1837 - 1846.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. C. Hendrix, E. A. Seftor, P. S. Meltzer, L. M. G. Gardner, A. R. Hess, D. A. Kirschmann, G. C. Schatteman, and R. E. B. Seftor
Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry
PNAS, June 12, 2001; (2001) 131209798.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. J. C. Hendrix, E. A. Seftor, P. S. Meltzer, L. M. G. Gardner, A. R. Hess, D. A. Kirschmann, G. C. Schatteman, and R. E. B. Seftor
Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry
PNAS, July 3, 2001; 98(14): 8018 - 8023.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.