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[Cancer Research 60, 6878-6881, December 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Molecular Prognostication of Nasopharyngeal Carcinoma by Quantitative Analysis of Circulating Epstein-Barr Virus DNA1

Y. M. Dennis Lo2, Anthony T. C. Chan, Lisa Y. S. Chan, Sing-Fai Leung, Ching-Wan Lam, Dolly P. Huang and Philip J. Johnson

Departments of Chemical Pathology [Y. M. D. L., L. Y. S. C., C-W. L.], Clinical Oncology & the Sir Y. K. Pao Cancer Center [A. T. C. C., S-F. L., P. J. J.], and Anatomical & Cellular Pathology [D. P. H.], The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region

We investigated the prognostic implication of pretreatment plasma/serum EBV DNA concentration, as measured by real-time quantitative PCR, in nasopharyngeal carcinoma (NPC). In 91 prospectively recruited NPC patients, those with recurrence or metastasis within the first year after treatment had a higher median plasma EBV DNA concentration than those without events (41,756 copies/ml versus 5,807 copies/ml; P < 0.001, Mann-Whitney rank-sum test). In multivariate logistic regression analysis, plasma EBV DNA was an independent prognostic indicator for early clinical events [relative risk = 3.8 (95% confidence interval, 1.6–9.2 for each 10-fold increase in plasma EBV DNA concentration; P = 0.003)]. In a second cohort of 139 NPC patients followed-up for a median period of 2,027 days (interquartile range, 597–2,335 days), serum EBV DNA was found to be a significant variable associated with NPC-related death in multivariate Cox’s regression analysis [relative risk = 1.6 (95% confidence interval, 1.1–2.1 for each 10-fold increase in serum EBV DNA concentration; P = 0.007)]. The quantitation of circulating EBV DNA may thus allow improved prognostication of NPC.




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Cancer Research Clinical Cancer Research
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