| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Tumor Biology |
Research Institute of Molecular Pathology, A-1030 Vienna, Austria
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis is well understood, the role of a second group of angiogenic factors, the fibroblast growth factors (FGFs), remains elusive. We used a recombinant adenovirus expressing soluble FGF receptor (AdsFGFR) to interfere with FGF function in tumor angiogenesis. AdsFGFR repressed endothelial cell proliferation in vitro and inhibited tumor angiogenesis in an ex vivo bioassay, in which endothelial cells were cocultured with angiogenic tumor biopsies in a collagen gel. Moreover, AdsFGFR repressed tumor angiogenesis and hence tumor growth in vivo in allograft transplantation experiments. Whereas adenoviral expression of a soluble form of VEGF receptor 1 (AdsFlt) predominantly affected the initiation of tumor angiogenesis, soluble FGF receptor (sFGFR) appeared to impair the maintenance of tumor angiogenesis. The combination of sFGFR and soluble Flt exhibited a synergistic effect in the repression of tumor growth. Finally, i.v. injection of AdsFGFR resulted in a dramatic repression of tumor growth in a transgenic mouse model of pancreatic ß cell carcinogenesis. Similar to control infections with AdsFlt, tumor-associated vessel density was decreased, indicating that the expression of sFGFR impaired tumor angiogenesis. These data indicate that FGFs play a critical role in tumor angiogenesis.
This article has been cited by other articles:
|
|
 |
|
  T. Schomber, A. Zumsteg, K. Strittmatter, I. Crnic, H. Antoniadis, A. Littlewood-Evans, J. Wood, and G. Christofori Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis Mol. Cancer Ther., January 1, 2009; 8(1): 55 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. U. Magnusson, A. Dimberg, S. Mellberg, A. Lukinius, and L. Claesson-Welsh FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin Blood, December 15, 2007; 110(13): 4214 - 4222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schomber, L. Kopfstein, V. Djonov, I. Albrecht, V. Baeriswyl, K. Strittmatter, and G. Christofori Placental Growth Factor-1 Attenuates Vascular Endothelial Growth Factor-A Dependent Tumor Angiogenesis during {beta} Cell Carcinogenesis Cancer Res., November 15, 2007; 67(22): 10840 - 10848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wicki, D. Wild, D. Storch, C. Seemayer, M. Gotthardt, M. Behe, S. Kneifel, M. J. Mihatsch, J.-C. Reubi, H. R. Macke, et al. [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 Is a Highly Efficient Radiotherapeutic for Glucagon-Like Peptide-1 Receptor-Targeted Therapy for Insulinoma Clin. Cancer Res., June 15, 2007; 13(12): 3696 - 3705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Kopfstein, T. Veikkola, V. G. Djonov, V. Baeriswyl, T. Schomber, K. Strittmatter, S. A. Stacker, M. G. Achen, K. Alitalo, and G. Christofori Distinct Roles of Vascular Endothelial Growth Factor-D in Lymphangiogenesis and Metastasis Am. J. Pathol., April 1, 2007; 170(4): 1348 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-C. Liu, T. Zhang, H. Fukuhara, T. Kuroda, T. Todo, X. Canron, A. Bikfalvi, R. L. Martuza, A. Kurtz, and S. D. Rabkin Dominant-Negative Fibroblast Growth Factor Receptor Expression Enhances Antitumoral Potency of Oncolytic Herpes Simplex Virus in Neural Tumors. Clin. Cancer Res., November 15, 2006; 12(22): 6791 - 6799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schaffhauser, T. Veikkola, K. Strittmatter, H. Antoniadis, K. Alitalo, and G. Christofori Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice J. Leukoc. Biol., October 1, 2006; 80(4): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Ezzat and S L Asa The molecular pathogenetic role of cell adhesion in endocrine neoplasia J. Clin. Pathol., November 1, 2005; 58(11): 1121 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Lopes de Menezes, J. Peng, E. N. Garrett, S. G. Louie, S. H. Lee, M. Wiesmann, Y. Tang, L. Shephard, C. Goldbeck, Y. Oei, et al. CHIR-258: A Potent Inhibitor of FLT3 Kinase in Experimental Tumor Xenograft Models of Human Acute Myelogenous Leukemia Clin. Cancer Res., July 15, 2005; 11(14): 5281 - 5291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. U. Magnusson, R. Ronca, P. Dell'Era, P. Carlstedt, L. Jakobsson, J. Partanen, A. Dimberg, and L. Claesson-Welsh Fibroblast Growth Factor Receptor-1 Expression Is Required for Hematopoietic but not Endothelial Cell Development Arterioscler Thromb Vasc Biol, May 1, 2005; 25(5): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dalal, A. M. Berry, C. J. Cullinane, D. C. Mangham, R. Grimer, I. J. Lewis, C. Johnston, V. Laurence, and S. A. Burchill Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family Clin. Cancer Res., March 15, 2005; 11(6): 2364 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Crnic, K. Strittmatter, U. Cavallaro, L. Kopfstein, L. Jussila, K. Alitalo, and G. Christofori Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis Cancer Res., December 1, 2004; 64(23): 8630 - 8638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. MacKenzie, P. Duriez, B. Larrivee, L. Chang, I. Pollet, F. Wong, C. Yip, and A. Karsan Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-J{kappa} Blood, September 15, 2004; 104(6): 1760 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Emanuel, R. H. Gruninger, A. Fuentes-Pesquera, P. J. Connolly, J. A. Seamon, S. Hazel, R. Tominovich, B. Hollister, C. Napier, M. R. D'Andrea, et al. A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models Mol. Pharmacol., September 1, 2004; 66(3): 635 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mandler and A. Neubuser FGF signaling is required for initiation of feather placode development Development, July 15, 2004; 131(14): 3333 - 3343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tsutsumi, Y. Yonemitsu, Y. Shikada, M. Onimaru, M. Tanii, S. Okano, K. Kaneko, M. Hasegawa, M. Hashizume, Y. Maehara, et al. Essential Role of PDGFR{alpha}-p70S6K Signaling in Mesenchymal Cells During Therapeutic and Tumor Angiogenesis In Vivo: Role of PDGFR{alpha} During Angiogenesis Circ. Res., May 14, 2004; 94(9): 1186 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A H G Hansma, Y van Hensbergen, B C Kuenen, P J van Diest, R Hanemaaijer, S Meijer, H M Pinedo, and K Hoekman A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour J. Clin. Pathol., May 1, 2004; 57(5): 536 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Rousseau, F. Larrieu-Lahargue, S. Javerzat, F. Guilhem-Ducleon, F. Beermann, and A. Bikfalvi The tyrp1-Tag/tyrp1-FGFR1-DN Bigenic Mouse: A Model for Selective Inhibition of Tumor Development, Angiogenesis, and Invasion into the Neural Tissue by Blockade of Fibroblast Growth Factor Receptor Activity Cancer Res., April 1, 2004; 64(7): 2490 - 2495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Magnusson, C. Rolny, L. Jakobsson, C. Wikner, Y. Wu, D. J. Hicklin, and L. Claesson-Welsh Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development J. Cell Sci., March 15, 2004; 117(8): 1513 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zilberberg, S. Shinkaruk, O. Lequin, B. Rousseau, M. Hagedorn, F. Costa, D. Caronzolo, M. Balke, X. Canron, O. Convert, et al. Structure and Inhibitory Effects on Angiogenesis and Tumor Development of a New Vascular Endothelial Growth Inhibitor J. Biol. Chem., September 12, 2003; 278(37): 35564 - 35573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Giavazzi, B. Sennino, D. Coltrini, A. Garofalo, R. Dossi, R. Ronca, M. P. M. Tosatti, and M. Presta Distinct Role of Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor on Tumor Growth and Angiogenesis Am. J. Pathol., June 1, 2003; 162(6): 1913 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Woodman, A. W. Ashton, W. Schubert, H. Lee, T. M. Williams, F. A. Medina, J. B. Wyckoff, T. P. Combs, and M. P. Lisanti Caveolin-1 Knockout Mice Show an Impaired Angiogenic Response to Exogenous Stimuli Am. J. Pathol., June 1, 2003; 162(6): 2059 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Straume and L. A. Akslen Importance of Vascular Phenotype by Basic Fibroblast Growth Factor, and Influence of the Angiogenic Factors Basic Fibroblast Growth Factor/Fibroblast Growth Factor Receptor-1 and Ephrin-A1/EphA2 on Melanoma Progression Am. J. Pathol., March 1, 2002; 160(3): 1009 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Seno, M. Oshima, T.-o Ishikawa, H. Oshima, K. Takaku, T. Chiba, S. Narumiya, and M. M. Taketo Cyclooxygenase 2- and Prostaglandin E2 Receptor EP2-dependent Angiogenesis in Apc{Delta}716 Mouse Intestinal Polyps Cancer Res., January 1, 2002; 62(2): 506 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gannon, S. J. Mandriota, L. Cui, D. Baetens, M. S. Pepper, and G. Christofori Overexpression of Vascular Endothelial Growth Factor-A165 Enhances Tumor Angiogenesis but not Metastasis during {beta}-Cell Carcinogenesis Cancer Res., January 1, 2002; 62(2): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Leali, M. Belleri, C. Urbinati, D. Coltrini, P. Oreste, G. Zoppetti, D. Ribatti, M. Rusnati, and M. Presta Fibroblast Growth Factor-2 Antagonist Activity and Angiostatic Capacity of Sulfated Escherichia coli K5 Polysaccharide Derivatives J. Biol. Chem., October 5, 2001; 276(41): 37900 - 37908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Papetti and I. M. Herman Mechanisms of normal and tumor-derived angiogenesis Am J Physiol Cell Physiol, May 1, 2002; 282(5): C947 - C970. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
