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No Evidence of Peutz-Jeghers Syndrome Gene LKB1 Involvement in Left-sided Colorectal Carcinomas¹

Departments of Medical Genetics [V. L., E. A., A. L., P. L., L. A. A.] and Pathology [R. S.], Haartman Institute, University of Helsinki, Helsinki FIN-00014, Finland; Second Department of Surgery, Helsinki University Central Hospital, Helsinki, FIN-00290 Finland [H. J.]; Department of Surgery, Central Hospital of Jyväskylä, FIN-40620 Jyväskylä, Finland [J-P. M.]; University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, Korea [H. C. K., J. C. K.]; and Gene Search Program, Chugai Research Institute For Molecular Medicine, Inc., Ibaraki 300-4101, Japan [A. O., M. S., J-i. N.]

LKB1 serine/threonine kinase is a gene for Peutz-Jeghers cancer predisposition syndrome. Most studies have detected a low frequency of LKB1 defects in sporadic cancer. A notable exception is a recent report describing frequent, mostly missense type, LKB1 mutations in Korean distal colorectal tumors. To clarify the role of LKB1 in colon cancer, we scrutinized 50 left-sided Korean and Finnish specimens. No somatic mutations were found. The seven Korean somatic missense mutations reported previously were functionally analyzed, and five were found not to alter LKB1 kinase activity. One of these changes was found to be a germ-line polymorphism. LKB1 involvement in distal colorectal cancer is not common.

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