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[Cancer Research 60, 779-782, February 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

A Calcitriol Analogue, EB1089, Inhibits the Growth of LNCaP Tumors in Nude Mice1

Sarah E. Blutt, Tara C. Polek, LaMonica V. Stewart, Michael W. Kattan and Nancy L. Weigel2

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 [S. E. B., T. C. P., L. V. S., N. L. W.], and Departments of Urology and Biostatistics and Epidemiology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [M. W. K.]

Limited options for the treatment of prostate cancer have spurred the search for new therapies. One innovative approach is the use of 1{alpha},25-dihydroxyvitamin D3 (calcitriol) analogues to inhibit cancer growth. We demonstrate here that the calcitriol analogue, EB1089, extensively inhibits the growth of LNCaP prostate cancer cells in culture and causes the cells to both accumulate in G0-G1 and undergo apoptosis. Importantly, we found that EB1089 inhibits the growth of LNCaP tumor xenografts in nude mice. Because of these antiproliferative properties in vivo, EB1089 is a potential new therapeutic agent for the treatment of prostate cancer.




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