Cancer Research AACR Membership Genetics and Biology of Brain Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edelmann, W.
Right arrow Articles by Kucherlapati, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edelmann, W.
Right arrow Articles by Kucherlapati, R.
[Cancer Research 60, 803-807, February 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

The DNA Mismatch Repair Genes Msh3 and Msh6 Cooperate in Intestinal Tumor Suppression1

Winfried Edelmann, Asad Umar, Kan Yang, Joerg Heyer, Melanie Kucherlapati, Marie Lia, Burkhard Kneitz, Elena Avdievich, Kunhua Fan, Edmund Wong, Gray Crouse, Thomas Kunkel, Martin Lipkin, Richard D. Kolodner and Raju Kucherlapati2

Departments of Cell Biology [W. E., B. K., E. A., E. W.] and Molecular Genetics [W. E., J. H., M. K., M. Lia, E. W., R. K.], Albert Einstein College of Medicine, Bronx, New York 10461; Laboratory of Molecular Genetics, National Institute of Environmental Health Services, Research Triangle Park, North Carolina 27700 [A. U., T. K.]; Strang Cancer Prevention Center, New York, New York 10021 [K. Y., K. F., M. Lip.]; Emory University, Atlanta, Georgia 30322 [G. C.]; Ludwig Institute for Cancer Research, La Jolla, California 92093 [R. D. K.]

Repair of mismatches in DNA in mammalian cells is mediated by a complex of proteins that are members of two highly conserved families of genes referred to as MutS and MutL homologues. Germline mutations in several members of these families, MSH2, MSH6, MLH1, and PMS2, but not MSH3, are responsible for hereditary non-polyposis colorectal cancer. To examine the role of MSH3, we generated a mouse with a null mutation in this gene. Cells from Msh3-/- mice are defective in repair of insertion/deletion mismatches but can repair base-base mismatches. Msh3-/- mice develop tumors at a late age. When the Msh3-/- and Msh6-/- mutations are combined, the tumor predisposition phenotype is indistinguishable from Msh2-/- or Mlh1-/- mice. These results suggest that MSH3 cooperates with MSH6 in tumor suppression.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
R. A. Edwards, M. Witherspoon, K. Wang, K. Afrasiabi, T. Pham, L. Birnbaumer, and S. M. Lipkin
Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease-Associated Colorectal Cancer
Cancer Res., August 15, 2009; 69(16): 6423 - 6429.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. C. Haugen, A. Goel, K. Yamada, G. Marra, T.-P. Nguyen, T. Nagasaka, S. Kanazawa, J. Koike, Y. Kikuchi, X. Zhong, et al.
Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
Cancer Res., October 15, 2008; 68(20): 8465 - 8472.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Feitsma, R. V. Kuiper, J. Korving, I. J. Nijman, and E. Cuppen
Zebrafish with Mutations in Mismatch Repair Genes Develop Neurofibromas and Other Tumors
Cancer Res., July 1, 2008; 68(13): 5059 - 5066.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. K. Rustgi
The genetics of hereditary colon cancer
Genes & Dev., October 15, 2007; 21(20): 2525 - 2538.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
D. C. Hegan, L. Narayanan, F. R. Jirik, W. Edelmann, R.M. Liskay, and P. M. Glazer
Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6
Carcinogenesis, December 1, 2006; 27(12): 2402 - 2408.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Modrich
Mechanisms in Eukaryotic Mismatch Repair
J. Biol. Chem., October 13, 2006; 281(41): 30305 - 30309.
[Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. C. Chao and S. M. Lipkin
Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis
Nucleic Acids Res., February 6, 2006; 34(3): 840 - 852.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. Larijani, A. Zaheen, D. Frieder, Y. Wang, G. E. Wu, W. Edelmann, and A. Martin
Lack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining events
Nucleic Acids Res., November 27, 2005; 33(21): 6733 - 6742.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
N. K. Kolas, A. Svetlanov, M. L. Lenzi, F. P. Macaluso, S. M. Lipkin, R. M. Liskay, J. Greally, W. Edelmann, and P. E. Cohen
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
J. Cell Biol., November 7, 2005; 171(3): 447 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P.-C. Chen, S. Dudley, W. Hagen, D. Dizon, L. Paxton, D. Reichow, S.-R. Yoon, K. Yang, N. Arnheim, R. M. Liskay, et al.
Contributions by MutL Homologues Mlh3 and Pms2 to DNA Mismatch Repair and Tumor Suppression in the Mouse
Cancer Res., October 1, 2005; 65(19): 8662 - 8670.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. R. Campbell, P. N. Nation, and S. E. Andrew
A Lack of DNA Mismatch Repair on an Athymic Murine Background Predisposes to Hematologic Malignancy
Cancer Res., April 1, 2005; 65(7): 2626 - 2635.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
E. T. Hawk and B. Levin
Colorectal Cancer Prevention
J. Clin. Oncol., January 10, 2005; 23(2): 378 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. Hamatani, G. Falco, M. G. Carter, H. Akutsu, C. A. Stagg, A. A. Sharov, D. B. Dudekula, V. VanBuren, and M. S.H. Ko
Age-associated alteration of gene expression patterns in mouse oocytes
Hum. Mol. Genet., October 1, 2004; 13(19): 2263 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Z. Li, S. J. Scherer, D. Ronai, M. D. Iglesias-Ussel, J. U. Peled, P. D. Bardwell, M. Zhuang, K. Lee, A. Martin, W. Edelmann, et al.
Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody Diversification
J. Exp. Med., July 6, 2004; 200(1): 47 - 59.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. M. Ward and D. E. Devor-Henneman
Mouse Models of Human Familial Cancer Syndromes
Toxicol Pathol, January 1, 2004; 32(1_suppl): 90 - 98.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
K. Wei, A. B. Clark, E. Wong, M. F. Kane, D. J. Mazur, T. Parris, N. K. Kolas, R. Russell, H. Hou Jr., B. Kneitz, et al.
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
Genes & Dev., March 1, 2003; 17(5): 603 - 614.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E. C. Matheson and A. G. Hall
Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia
Carcinogenesis, January 1, 2003; 24(1): 31 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Kucherlapati, K. Yang, M. Kuraguchi, J. Zhao, M. Lia, J. Heyer, M. F. Kane, K. Fan, R. Russell, A. M. C. Brown, et al.
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
PNAS, July 23, 2002; 99(15): 9924 - 9929.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
R. Kariola, T. E. Raevaara, K. E. Lonnqvist, and M. Nystrom-Lahti
Functional analysis of MSH6 mutations linked to kindreds with putative hereditary non-polyposis colorectal cancer syndrome
Hum. Mol. Genet., May 16, 2002; 11(11): 1303 - 1310.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Lan, Z. Sever-Chroneos, M. W. Strobeck, C.-H. Park, R. Baskaran, W. Edelmann, G. Leone, and E. S. Knudsen
DNA Damage Invokes Mismatch Repair-dependent Cyclin D1 Attenuation and Retinoblastoma Signaling Pathways to Inhibit CDK2
J. Biol. Chem., March 1, 2002; 277(10): 8372 - 8381.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Kuraguchi, K. Yang, E. Wong, E. Avdievich, K. Fan, R. D. Kolodner, M. Lipkin, A. M. C. Brown, R. Kucherlapati, and W. Edelmann
The Distinct Spectra of Tumor-associated Apc Mutations in Mismatch Repair-deficient Apc1638N Mice Define the Roles of MSH3 and MSH6 in DNA Repair and Intestinal Tumorigenesis
Cancer Res., November 1, 2001; 61(21): 7934 - 7942.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. S. Xu, L. Narayanan, B. Dunklee, R. M. Liskay, and P. M. Glazer
Hypermutability to Ionizing Radiation in Mismatch Repair-deficient, Pms2 Knockout Mice
Cancer Res., May 1, 2001; 61(9): 3775 - 3780.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. Huang, S. A. Kuismanen, T. Liu, R. B. Chadwick, C. K. Johnson, M. W. Stevens, S. K. Richards, J. E. Meek, X. Gao, F. A. Wright, et al.
MSH6 and MSH3 Are Rarely Involved in Genetic Predisposition to Nonpolypotic Colon Cancer
Cancer Res., February 1, 2001; 61(4): 1619 - 1623.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
M. Z. Hadi, M. A. Coleman, K. Fidelis, H. W. Mohrenweiser, and D. M. Wilson III
Functional characterization of Ape1 variants identified in the human population
Nucleic Acids Res., October 15, 2000; 28(20): 3871 - 3879.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
T. Hassold, S. Sherman, and P. Hunt
Counting cross-overs: characterizing meiotic recombination in mammals
Hum. Mol. Genet., October 1, 2000; 9(16): 2409 - 2419.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. Kneitz, P. E. Cohen, E. Avdievich, L. Zhu, M. F. Kane, H. Hou Jr., R. D. Kolodner, R. Kucherlapati, J. W. Pollard, and W. Edelmann
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
Genes & Dev., May 1, 2000; 14(9): 1085 - 1097.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.