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[Cancer Research 60, 834-838, February 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Overexpression of Insulin-like Growth Factor-binding Protein-2 Results in Increased Tumorigenic Potential in Y-1 Adrenocortical Tumor Cells1

Andreas Hoeflich2, Olga Fettscher, Harald Lahm, Werner F. Blum, Helmut J. Kolb, Dieter Engelhardt, Eckhard Wolf and Matthias M. Weber

Lehrstuhl für Molekulare Tierzucht und Haustiergenetik/Genzentrum [A. H., H. L., E. W.], and Laboratory of Endocrine Research, Medical Department II, Klinikum Grosshadern [O. F., D. E., M. M. W.], Ludwig-Maximilians-Universität, 81377 Munich, Germany; Lilly Germany, 61350 Bad Homburg, Germany [W. F. B.]; and Institut für Klinische Chemie, Städtisches Krankenhaus München-Harlaching, 81545 Munich, Germany [H. J. K.]

Increased concentrations of insulin-like growth factor-binding protein-2 (IGFBP-2) have been observed in human malignancies including adrenocortical carcinomas. To elucidate the functional consequences of IGFBP-2 overexpression, we have stably transfected the cDNA of murine IGFBP-2 in mouse adrenocortical tumor cells (Y-1). Long-term overexpression of IGFBP-2 was associated with significant morphological alterations, enhanced cell proliferation, and increased cloning efficiency as compared with mock transfected control cells. The enhanced proliferation of IGFBP-2 secreting clones was independent of exogenous insulin-like growth factors (IGFs). These data suggest that elevated levels of IGFBP-2 may contribute to the highly malignant phenotype of adrenocortical cancer by a thus far unknown, presumably IGF-independent, mechanism.




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