Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lin, B.
Right arrow Articles by Nelson, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lin, B.
Right arrow Articles by Nelson, P. S.
[Cancer Research 60, 858-863, February 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

PART-1: A Novel Human Prostate-specific, Androgen-regulated Gene that Maps to Chromosome 5q121

Biaoyang Lin, James T. White, Camari Ferguson, Roger Bumgarner, Cynthia Friedman, Barbara Trask, William Ellis, Paul Lange, Leroy Hood and Peter S. Nelson2

Departments of Molecular Biotechnology [B. L., J. T. W., C. Fe., C. Fr., B. T., L. H., P. S. N.], Medicine [P. S. N.], Microbiology [R. B.], and Urology [W. E., P. L.], University of Washington, Seattle, Washington 98195

Genes regulated by androgenic hormones are of critical importance for the normal physiological function of the human prostate gland, and they contribute to the development and progression of prostate carcinoma. We used cDNA microarrays containing 1500 prostate-derived cDNAs to profile transcripts regulated by androgens in prostate cancer cells. This study identified a novel gene that we have designated PART-1 (prostate androgen-regulated transcript 1), which exhibited increased expression upon exposure to androgens in the LNCaP prostate cancer cell line. Northern analysis demonstrated that PART-1 is highly expressed in the prostate gland relative to other normal human tissues and is expressed as different transcripts using at least three different polyadenylation signals. The PART-1 cDNA and putative protein are not significantly homologous to any sequences in the nonredundant public sequence databases. Cloning and analysis of the putative PART-1 promoter region identified a potential binding site for the homeobox gene PBX-1a, but no consensus androgen response element or sterol-regulatory element binding sites were identified. We used a radiation hybrid panel and fluorescence in situ hybridization to map the PART-1 gene to chromosome 5q12, a region that has been suggested to harbor a prostate tumor suppressor gene. These results identify a new gene involved in the androgen receptor-regulated gene network of the human prostate that may play a role in the etiology of prostate carcinogenesis.




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Guo, L. Hood, M. Malkki, and E. W. Petersdorf
Long-range multilocus haplotype phasing of the MHC
PNAS, May 2, 2006; 103(18): 6964 - 6969.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Jonsson, T. L. Naylor, J. Vallon-Christersson, J. Staaf, J. Huang, M. R. Ward, J. D. Greshock, L. Luts, H. Olsson, N. Rahman, et al.
Distinct Genomic Profiles in Hereditary Breast Tumors Identified by Array-Based Comparative Genomic Hybridization
Cancer Res., September 1, 2005; 65(17): 7612 - 7621.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
W. H Walker and J. Cheng
FSH and testosterone signaling in Sertoli cells
Reproduction, July 1, 2005; 130(1): 15 - 28.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Maeda, S. Nagata, C. D. Wolfgang, G. L. Bratthauer, T. K. Bera, and I. Pastan
The T Cell Receptor {gamma} Chain Alternate Reading Frame Protein (TARP), a Prostate-specific Protein Localized in Mitochondria
J. Biol. Chem., June 4, 2004; 279(23): 24561 - 24568.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Wang, J. Xu, O. Saramaki, T. Visakorpi, W. M. Sutherland, J. Zhou, B. Sen, S. D. Lim, N. Mabjeesh, M. Amin, et al.
PrLZ, a Novel Prostate-Specific and Androgen-Responsive Gene of the TPD52 Family, Amplified in Chromosome 8q21.1 and Overexpressed in Human Prostate Cancer
Cancer Res., March 1, 2004; 64(5): 1589 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
L. Yu, G. L. Blackburn, and J.-R. Zhou
Genistein and Daidzein Downregulate Prostate Androgen-Regulated Transcript-1 (PART-1) Gene Expression Induced by Dihydrotestosterone in Human Prostate LNCaP Cancer Cells
J. Nutr., February 1, 2003; 133(2): 389 - 392.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. A. Herness and R. K. Naz
A Novel Human Prostate-specific Gene-1 (HPG-1): Molecular Cloning, Sequencing, and Its Potential Involvement in Prostate Carcinogenesis
Cancer Res., January 15, 2003; 63(2): 329 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
P. S. NELSON
Identifying Immunotherapeutic Targets for Prostate Carcinoma through the Analysis of Gene Expression Profiles
Ann. N.Y. Acad. Sci., December 1, 2002; 975(1): 232 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. L. Dennis, J. K. Vass, E. C. Wit, W. N. Keith, and K. A. Oien
Identification from Public Data of Molecular Markers of Adenocarcinoma Characteristic of the Site of Origin
Cancer Res., November 1, 2002; 62(21): 5999 - 6005.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Xia, D. Robinson, A.-H. Ma, H.-C. Chen, F. Wu, Y. Qiu, and H.-J. Kung
Identification of Human Male Germ Cell-associated Kinase, a Kinase Transcriptionally Activated by Androgen in Prostate Cancer Cells
J. Biol. Chem., September 13, 2002; 277(38): 35422 - 35433.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Yang, G. E. Holt, M. P. Velders, E. D. Kwon, and W. M. Kast
Murine Six-Transmembrane Epithelial Antigen of the Prostate, Prostate Stem Cell Antigen, and Prostate-specific Membrane Antigen: Prostate-specific Cell-Surface Antigens Highly Expressed in Prostate Cancer of Transgenic Adenocarcinoma Mouse Prostate Mice
Cancer Res., August 1, 2001; 61(15): 5857 - 5860.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Lin, J. T. White, C. Ferguson, S. Wang, R. Vessella, R. Bumgarner, L. D. True, L. Hood, and P. S. Nelson
Prostate Short-Chain Dehydrogenase Reductase 1 (PSDR1): A New Member of the Short-Chain Steroid Dehydrogenase/Reductase Family Highly Expressed in Normal and Neoplastic Prostate Epithelium
Cancer Res., February 1, 2001; 61(4): 1611 - 1618.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
L. L. Xu, B. G. Stackhouse, K. Florence, W. Zhang, N. Shanmugam, I. A. Sesterhenn, Z. Zou, V. Srikantan, M. Augustus, V. Roschke, et al.
PSGR, a Novel Prostate-specific Gene with Homology to a G Protein-coupled Receptor, Is Overexpressed in Prostate Cancer
Cancer Res., December 1, 2000; 60(23): 6568 - 6572.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
J. Dannull, P.-A. Diener, L. Prikler, G. Fürstenberger, T. Cerny, U. Schmid, D. K. Ackermann, and M. Groettrup
Prostate Stem Cell Antigen Is a Promising Candidate for Immunotherapy of Advanced Prostate Cancer
Cancer Res., October 1, 2000; 60(19): 5522 - 5528.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
Copyright © 2000 by the American Association for Cancer Research.