Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Susan G. Komen for the Cure-AACR Outstanding Investigator Award for Breast Cancer Research
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koong, A. C.
Right arrow Articles by Giaccia, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koong, A. C.
Right arrow Articles by Giaccia, A. J.
[Cancer Research 60, 883-887, February 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Candidate Genes for the Hypoxic Tumor Phenotype1

Albert C. Koong, Nicholas C. Denko, Karen M. Hudson, Cornelia Schindler, Lillian Swiersz, Cameron Koch, Sydney Evans, Hani Ibrahim, Quynh T. Le, David J. Terris and Amato J. Giaccia2

Departments of Radiation Oncology [A. C. K., N. C. D., K. M. H., C. S., L. S., Q. T. L., A. J. G.] and Otolaryngology/Head and Neck Surgery [D. J. T., H. I.], Stanford University School of Medicine, Stanford, California 94305-5468, and Division of Oncology Research, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 [C. K., S. E.]

In this study, we have analyzed changes induced by hypoxia at the transcriptional level of genes that could be responsible for a more aggressive phenotype. Using a series of DNA array membranes, we identified a group of hypoxia-induced genes that included plasminogen activator inhibitor-1 (PAI-1), insulin-like growth factor-binding protein 3 (IGFBP-3), endothelin-2, low-density lipoprotein receptor-related protein (LRP), BCL2-interacting killer (BIK), migration-inhibitory factor (MIF), matrix metalloproteinase-13 (MMP-13), fibroblast growth factor-3 (FGF-3), GADD45, and vascular endothelial growth factor (VEGF). The induction of each gene was confirmed by Northern blot analysis in two different squamous cell carcinoma-derived cell lines. We also analyzed the kinetics of PAI-1 induction by hypoxia in more detail because it is a secreted protein that may serve as a useful molecular marker of hypoxia. On exposure to hypoxia, there was a gradual increase in PAI-1 mRNA between 2 and 24 h of hypoxia followed by a rapid decay after 2 h of reoxygenation. PAI-1 levels were also measured in the serum of a small group of head and neck cancer patients and were found to correlate with the degree of tumor hypoxia found in these patients.




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. L. Damico, A. Chesley, L. Johnston, E. P. Bind, E. Amaro, J. Nijmeh, B. Karakas, L. Welsh, D. B. Pearse, J. G. N. Garcia, et al.
Macrophage Migration Inhibitory Factor Governs Endothelial Cell Sensitivity to LPS-Induced Apoptosis
Am. J. Respir. Cell Mol. Biol., July 1, 2008; 39(1): 77 - 85.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Chen, G. Bu, Y. Takei, K. Sakamoto, S. Ikematsu, T. Muramatsu, and K. Kadomatsu
Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells
J. Cell Sci., November 15, 2007; 120(22): 4009 - 4015.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Montel, A. Gaultier, R. D. Lester, W. M. Campana, and S. L. Gonias
The Low-Density Lipoprotein Receptor Related Protein Regulates Cancer Cell Survival and Metastasis Development
Cancer Res., October 15, 2007; 67(20): 9817 - 9824.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Ye, Z. Gao, J. Yin, and Q. He
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1118 - E1128.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
M J Grimshaw
Endothelins and hypoxia-inducible factor in cancer
Endocr. Relat. Cancer, June 1, 2007; 14(2): 233 - 244.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
A. Wouters, B. Pauwels, F. Lardon, and J. B. Vermorken
Review: Implications of In Vitro Research on the Effect of Radiotherapy and Chemotherapy Under Hypoxic Conditions
Oncologist, June 1, 2007; 12(6): 690 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Y. Tan, L. Campo, C. Han, H. Turley, F. Pezzella, K. C. Gatter, A. L. Harris, and S. B. Fox
BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions in In situ Versus Invasive Cancer
Clin. Cancer Res., January 15, 2007; 13(2): 467 - 474.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Karakiulakis, E. Papakonstantinou, A. J. Aletras, M. Tamm, and M. Roth
Cell Type-specific Effect of Hypoxia and Platelet-derived Growth Factor-BB on Extracellular Matrix Turnover and Its Consequences for Lung Remodeling
J. Biol. Chem., January 12, 2007; 282(2): 908 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Winner, A. C. Koong, B. E. Rendon, W. Zundel, and R. A. Mitchell
Amplification of Tumor Hypoxic Responses by Macrophage Migration Inhibitory Factor-Dependent Hypoxia-Inducible Factor Stabilization
Cancer Res., January 1, 2007; 67(1): 186 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Ietta, Y. Wu, R. Romagnoli, N. Soleymanlou, B. Orsini, S. Zamudio, L. Paulesu, and I. Caniggia
Oxygen regulation of macrophage migration inhibitory factor in human placenta
Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E272 - E280.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Maity and C. Koumenis
HIF and MIF--a nifty way to delay senescence?
Genes & Dev., December 15, 2006; 20(24): 3337 - 3341.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
S. M. Welford, B. Bedogni, K. Gradin, L. Poellinger, M. Broome Powell, and A. J. Giaccia
HIF1{alpha} delays premature senescence through the activation of MIF
Genes & Dev., December 15, 2006; 20(24): 3366 - 3371.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. L. Ramnaraine, W. E. Mathews, J. M. Donohue, C. M. Lynch, M. J. Goblirsch, and D. R. Clohisy
Osteoclasts Direct Bystander Killing of Bone Cancer.
Cancer Res., November 15, 2006; 66(22): 10929 - 10935.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Chakraborty, H. Rangaswami, S. Jain, and G. C. Kundu
Hypoxia Regulates Cross-talk between Syk and Lck Leading to Breast Cancer Progression and Angiogenesis
J. Biol. Chem., April 21, 2006; 281(16): 11322 - 11331.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Gottfried, L. A. Kunz-Schughart, S. Ebner, W. Mueller-Klieser, S. Hoves, R. Andreesen, A. Mackensen, and M. Kreutz
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
Blood, March 1, 2006; 107(5): 2013 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. K. Williamson, J. J. Crowley, P. N. Lara Jr, J. McCoy, D. H.M. Lau, R. W. Tucker, G. M. Mills, and D. R. Gandara
Phase III Trial of Paclitaxel Plus Carboplatin With or Without Tirapazamine in Advanced Non-Small-Cell Lung Cancer: Southwest Oncology Group Trial S0003
J. Clin. Oncol., December 20, 2005; 23(36): 9097 - 9104.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
Q.-T. Le, G. Shi, H. Cao, D. W. Nelson, Y. Wang, E. Y. Chen, S. Zhao, C. Kong, D. Richardson, K. J. O'Byrne, et al.
Galectin-1: A Link Between Tumor Hypoxia and Tumor Immune Privilege
J. Clin. Oncol., December 10, 2005; 23(35): 8932 - 8941.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
D. E. Feldman, V. Chauhan, and A. C. Koong
The Unfolded Protein Response: A Novel Component of the Hypoxic Stress Response in Tumors
Mol. Cancer Res., November 1, 2005; 3(11): 597 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Yao, S. Shida, M. Selvakumaran, R. Zimmerman, E. Simon, J. Schick, N. B. Haas, M. Balke, H. Ross, S. W. Johnson, et al.
Macrophage Migration Inhibitory Factor Is a Determinant of Hypoxia-Induced Apoptosis in Colon Cancer Cell Lines
Clin. Cancer Res., October 15, 2005; 11(20): 7264 - 7272.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Cancello, C. Henegar, N. Viguerie, S. Taleb, C. Poitou, C. Rouault, M. Coupaye, V. Pelloux, D. Hugol, J.-L. Bouillot, et al.
Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss
Diabetes, August 1, 2005; 54(8): 2277 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. H. Chau, C. A. Clavijo, H.-T. Deng, Q. Zhang, K.-J. Kim, Y. Qiu, A. D. Le, and D. K. Ann
Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems
Am J Physiol Cell Physiol, August 1, 2005; 289(2): C444 - C454.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Grimberg, C. M. Coleman, T. F. Burns, B. P. Himelstein, C. J. Koch, P. Cohen, and W. S. El-Deiry
p53-Dependent and p53-Independent Induction of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid Damage and Hypoxia
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3568 - 3574.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Wang, D. A. Davis, M. Haque, L. E. Huang, and R. Yarchoan
Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1{alpha} and Hypoxia-Inducible Factor-2{alpha} in HEK293T Cells
Cancer Res., April 15, 2005; 65(8): 3299 - 3306.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. M. Evans, K. D. Judy, I. Dunphy, W. T. Jenkins, W.-T. Hwang, P. T. Nelson, R. A. Lustig, K. Jenkins, D. P. Magarelli, S. M. Hahn, et al.
Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors
Clin. Cancer Res., December 15, 2004; 10(24): 8177 - 8184.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
P. Vaupel
The Role of Hypoxia-Induced Factors in Tumor Progression
Oncologist, November 1, 2004; 9(suppl_5): 10 - 17.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Harrison and K. Blackwell
Hypoxia and Anemia: Factors in Decreased Sensitivity to Radiation Therapy and Chemotherapy?
Oncologist, November 1, 2004; 9(suppl_5): 31 - 40.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Chen, G. Shi, W. Xia, C. Kong, S. Zhao, A. F. Gaw, E. Y. Chen, G. P. Yang, A. J. Giaccia, Q.-T. Le, et al.
Identification of Hypoxia-Regulated Proteins in Head and Neck Cancer by Proteomic and Tissue Array Profiling
Cancer Res., October 15, 2004; 64(20): 7302 - 7310.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Murdoch, A. Giannoudis, and C. E. Lewis
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
Blood, October 15, 2004; 104(8): 2224 - 2234.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. D. Blais, V. Filipenko, M. Bi, H. P. Harding, D. Ron, C. Koumenis, B. G. Wouters, and J. C. Bell
Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress
Mol. Cell. Biol., September 1, 2004; 24(17): 7469 - 7482.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Q.-T. Le, J. McCoy, S. Williamson, J. Ryu, L. E. Gaspar, M. J. Edelman, S. R. Dakhil, S. D. Sides, J. J. Crowley, and D. R. Gandara
Phase I Study of Tirapazamine Plus Cisplatin/Etoposide and Concurrent Thoracic Radiotherapy in Limited-Stage Small Cell Lung Cancer (S0004): A Southwest Oncology Group Study
Clin. Cancer Res., August 15, 2004; 10(16): 5418 - 5424.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. C. Murray, P. Symonds, W. Ward, M. Huggins, A. Tiga, K. Rice, Y. M. Heng, I. Todd, and R. A. Robins
Colorectal Cancer Cells Induce Lymphocyte Apoptosis by an Endothelial Monocyte-Activating Polypeptide-II-Dependent Mechanism
J. Immunol., January 1, 2004; 172(1): 274 - 281.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. H. Mahabeleshwar and G. C. Kundu
Tyrosine Kinase p56lck Regulates Cell Motility and Nuclear Factor {kappa}B-mediated Secretion of Urokinase Type Plasminogen Activator through Tyrosine Phosphorylation of I{kappa}B{alpha} following Hypoxia/Reoxygenation
J. Biol. Chem., December 26, 2003; 278(52): 52598 - 52612.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. S. HUANG, T.-Y. LING, W.-F. TSENG, Y.-H. HUANG, F.-M. TANG, S. M. LEAL, and J. S. HUANG
Cellular growth inhibition by IGFBP-3 and TGF-{beta}1 requires LRP-1
FASEB J, November 1, 2003; 17(14): 2068 - 2081.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. N. Lara Jr., D. I. Quinn, K. Margolin, F. J. Meyers, J. Longmate, P. Frankel, P. C. Mack, C. Turrell, P. Valk, J. Rao, et al.
SU5416 Plus Interferon {alpha} in Advanced Renal Cell Carcinoma: A Phase II California Cancer Consortium Study with Biological and Imaging Correlates of Angiogenesis Inhibition
Clin. Cancer Res., October 15, 2003; 9(13): 4772 - 4781.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. Burke, A. Giannoudis, K. P. Corke, D. Gill, M. Wells, L. Ziegler-Heitbrock, and C. E. Lewis
Hypoxia-Induced Gene Expression in Human Macrophages: Implications for Ischemic Tissues and Hypoxia-Regulated Gene Therapy
Am. J. Pathol., October 1, 2003; 163(4): 1233 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. N. Lara Jr., P. Frankel, P. C. Mack, P. H. Gumerlock, I. Galvin, C. L. Martel, J. Longmate, J. H. Doroshow, H. J. Lenz, D. H. M. Lau, et al.
Tirapazamine Plus Carboplatin and Paclitaxel in Advanced Malignant Solid Tumors: A California Cancer Consortium Phase I and Molecular Correlative Study
Clin. Cancer Res., October 1, 2003; 9(12): 4356 - 4362.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. Bachtiary, M. Schindl, R. Potter, B. Dreier, T. H. Knocke, J. A. Hainfellner, R. Horvat, and P. Birner
Overexpression of Hypoxia-inducible Factor 1{alpha} Indicates Diminished Response to Radiotherapy and Unfavorable Prognosis in Patients Receiving Radical Radiotherapy for Cervical Cancer
Clin. Cancer Res., June 1, 2003; 9(6): 2234 - 2240.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. M. Douglas and G. G. Haddad
Genetic Models in Applied Physiology: Invited Review: Effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest
J Appl Physiol, May 1, 2003; 94(5): 2068 - 2083.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. T. Mihaylova, R. S. Bindra, J. Yuan, D. Campisi, L. Narayanan, R. Jensen, F. Giordano, R. S. Johnson, S. Rockwell, and P. M. Glazer
Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells
Mol. Cell. Biol., May 1, 2003; 23(9): 3265 - 3273.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
B. Annabi, Y.-T. Lee, S. Turcotte, E. Naud, R. R. Desrosiers, M. Champagne, N. Eliopoulos, J. Galipeau, and R. Beliveau
Hypoxia Promotes Murine Bone-Marrow-Derived Stromal Cell Migration and Tube Formation
Stem Cells, May 1, 2003; 21(3): 337 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
Y. Jiang, W. Zhang, K. Kondo, J. M. Klco, T. B. St. Martin, M. R. Dufault, S. L. Madden, W. G. Kaelin Jr, and M. Nacht
Gene Expression Profiling in a Renal Cell Carcinoma Cell Line: Dissecting VHL and Hypoxia-Dependent Pathways
Mol. Cancer Res., April 1, 2003; 1(6): 453 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. A. Sonna, M. L. Cullivan, H. K. Sheldon, R. E. Pratt, and C. M. Lilly
Effect of hypoxia on gene expression by human hepatocytes (HepG2)
Physiol Genomics, February 6, 2003; 12(3): 195 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Bacher, J. Schrader, N. Thompson, K. Kuschela, D. Gemsa, G. Waeber, and J. Schlegel
Up-Regulation of Macrophage Migration Inhibitory Factor Gene and Protein Expression in Glial Tumor Cells during Hypoxic and Hypoglycemic Stress Indicates a Critical Role for Angiogenesis in Glioblastoma Multiforme
Am. J. Pathol., January 1, 2003; 162(1): 11 - 17.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. W. Chong, L. D. Horwitz, J. W. Moore, H. M. Sowter, and A. L. Harris
A Mycobacterial Iron Chelator, Desferri-Exochelin, Induces Hypoxia-inducible Factors 1 and 2, NIP3, and Vascular Endothelial Growth Factor in Cancer Cell Lines
Cancer Res., December 1, 2002; 62(23): 6924 - 6927.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. J. Grimshaw, S. Naylor, and F. R. Balkwill
Endothelin-2 Is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells
Mol. Cancer Ther., December 1, 2002; 1(14): 1273 - 1281.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Fukuzawa, J. Nishihira, N. Hasebe, T. Haneda, J. Osaki, T. Saito, T. Nomura, T. Fujino, N. Wakamiya, and K. Kikuchi
Contribution of Macrophage Migration Inhibitory Factor to Extracellular Signal-regulated Kinase Activation by Oxidative Stress in Cardiomyocytes
J. Biol. Chem., July 5, 2002; 277(28): 24889 - 24895.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Zatyka, N. F. da Silva, S. C. Clifford, M. R. Morris, M. S. Wiesener, K.-U. Eckardt, R. S. Houlston, F. M. Richards, F. Latif, and E. R. Maher
Identification of Cyclin D1 and Other Novel Targets for the von Hippel-Lindau Tumor Suppressor Gene by Expression Array Analysis and Investigation of Cyclin D1 Genotype as a Modifier in von Hippel-Lindau Disease
Cancer Res., July 1, 2002; 62(13): 3803 - 3811.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. J. Turner, J. W. Moore, A. Jones, C. F. Taylor, D. Cuthbert-Heavens, C. Han, R. D. Leek, K. C. Gatter, P. H. Maxwell, P. J. Ratcliffe, et al.
Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation
Cancer Res., May 1, 2002; 62(10): 2957 - 2961.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Fink, A. Kazlauskas, L. Poellinger, P. Ebbesen, and V. Zachar
Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1
Blood, March 15, 2002; 99(6): 2077 - 2083.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. K. Rofstad, H. Rasmussen, K. Galappathi, B. Mathiesen, K. Nilsen, and B. A. Graff
Hypoxia Promotes Lymph Node Metastasis in Human Melanoma Xenografts by Up-Regulating the Urokinase-Type Plasminogen Activator Receptor
Cancer Res., March 1, 2002; 62(6): 1847 - 1853.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. N. Coleman, J. B. Mitchell, and K. Camphausen
Tumor Hypoxia: Chicken, Egg, or a Piece of the Farm?
J. Clin. Oncol., February 1, 2002; 20(3): 610 - 615.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Koga, Y. Osuga, O. Tsutsumi, T. Yano, O. Yoshino, Y. Takai, H. Matsumi, H. Hiroi, K. Kugu, M. Momoeda, et al.
Demonstration of Angiogenin in Human Endometrium and Its Enhanced Expression in Endometrial Tissues in the Secretory Phase and the Decidua
J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5609 - 5614.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. Lal, H. Peters, B. St. Croix, Z. A. Haroon, M. W. Dewhirst, R. L. Strausberg, J. H. A. M. Kaanders, A. J. van der Kogel, and G. J. Riggins
Transcriptional Response to Hypoxia in Human Tumors
J Natl Cancer Inst, September 5, 2001; 93(17): 1337 - 1343.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. J. P. Beasley, C. C. Wykoff, P. H. Watson, R. Leek, H. Turley, K. Gatter, J. Pastorek, G. J. Cox, P. Ratcliffe, and A. L. Harris
Carbonic Anhydrase IX, an Endogenous Hypoxia Marker, Expression in Head and Neck Squamous Cell Carcinoma and its Relationship to Hypoxia, Necrosis, and Microvessel Density
Cancer Res., July 1, 2001; 61(13): 5262 - 5267.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. M. L. West, R. A. Cooper, J. A. Loncaster, D. P. Wilks, and M. Bromley
Tumor Vascularity: A Histological Measure of Angiogenesis and Hypoxia
Cancer Res., April 1, 2001; 61(7): 2907 - 2910.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
N. C. Denko and A. J. Giaccia
Tumor Hypoxia, the Physiological Link between Trousseau's Syndrome (Carcinoma-induced Coagulopathy) and Metastasis
Cancer Res., February 1, 2001; 61(3): 795 - 798.
[Full Text]

Home page
 Cancer Res.Home page
C. C. Wykoff, N. J. P. Beasley, P. H. Watson, K. J. Turner, J. Pastorek, A. Sibtain, G. D. Wilson, H. Turley, K. L. Talks, P. H. Maxwell, et al.
Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases
Cancer Res., December 1, 2000; 60(24): 7075 - 7083.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
X.-H. Ning, S.-H. Chen, C.-S. Xu, L. Li, L. Y. Yao, K. Qian, J. J. Krueger, O. M. Hyyti, and M. A. Portman
Molecular Biology of Thermoregulation: Selected Contribution: Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis
J Appl Physiol, May 1, 2002; 92(5): 2200 - 2207.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. P. Hale, R. D. Braun, W. M. Gwinn, P. K. Greer, and M. W. Dewhirst
Hypoxia in the thymus: role of oxygen tension in thymocyte survival
Am J Physiol Heart Circ Physiol, April 1, 2002; 282(4): H1467 - H1477.
[Abstract] [Full Text] [PDF]