This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Guo, H. Articles by Toole, B. P. Search for Related Content PubMed PubMed Citation Articles by Guo, H. Articles by Toole, B. P.

EMMPRIN (CD147), an Inducer of Matrix Metalloproteinase Synthesis, Also Binds Interstitial Collagenase to the Tumor Cell Surface¹

Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, Massachusetts 02111 [H. G., R. L., B. P. T.], and Departments of Research and Medicine, Veteran Affairs Medical Center, Northport, New York 11768 [S. Z.]

Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at the tumor cell surface. Complex formation was demonstrated by phage display, affinity chromatography, and immunocytochemistry. Presentation of MMP-1 complexed to EMMPRIN at the tumor cell surface may be important in modifying the tumor cell pericellular matrix to promote invasion.

This article has been cited by other articles:

				H. Tan, K. Ye, Z. Wang, and H. Tang Clinicopathologic Evaluation of Immunohistochemical CD147 and MMP-2 Expression in Differentiated Thyroid Carcinoma Jpn. J. Clin. Oncol., August 1, 2008; 38(8): 528 - 533. [Abstract] [Full Text] [PDF]

				Y. Koyama, H. Naruo, Y. Yoshitomi, S. Munesue, S. Kiyono, Y. Kusano, K. Hashimoto, T. Yokoi, H. Nakanishi, S. Shimizu, et al. Matrix Metalloproteinase-9 Associated with Heparan Sulphate Chains of GPI-Anchored Cell Surface Proteoglycans Mediates Motility of Murine Colon Adenocarcinoma Cells J. Biochem., May 1, 2008; 143(5): 581 - 592. [Abstract] [Full Text] [PDF]

				D. R. Yager, R. A. Kulina, and L. A. Gilman Wound Fluids: A Window Into the Wound Environment? International Journal of Lower Extremity Wounds, December 1, 2007; 6(4): 262 - 272. [Abstract] [PDF]

				J. Tang, H.-w. Zhou, J.-l. Jiang, X.-m. Yang, Y. Li, H.-X. Zhang, Z.-n. Chen, and W.-p. Guo {beta}ig-h3 Is Involved in the HAb18G/CD147-Mediated Metastasis Process in Human Hepatoma Cells Experimental Biology and Medicine, March 1, 2007; 232(3): 344 - 352. [Abstract] [Full Text] [PDF]

				M. Stefanidakis and E. Koivunen Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression Blood, September 1, 2006; 108(5): 1441 - 1450. [Abstract] [Full Text] [PDF]

				A. Pardo and M. Selman Matrix metalloproteases in aberrant fibrotic tissue remodeling. Proceedings of the ATS, January 1, 2006; 3(4): 383 - 388. [Abstract] [Full Text] [PDF]

				S. Zhou, H. Zhou, P. J. Walian, and B. K. Jap CD147 is a regulatory subunit of the {gamma}-secretase complex in Alzheimer's disease amyloid {beta}-peptide production PNAS, May 24, 2005; 102(21): 7499 - 7504. [Abstract] [Full Text] [PDF]

				B. Davidson, S. Konstantinovsky, S. Nielsen, H. P. Dong, A. Berner, M. Vyberg, and R. Reich Altered Expression of Metastasis-Associated and Regulatory Molecules in Effusions from Breast Cancer Patients: A Novel Model for Tumor Progression Clin. Cancer Res., November 1, 2004; 10(21): 7335 - 7346. [Abstract] [Full Text] [PDF]

				E. Mira, R. A. Lacalle, J. M. Buesa, G. G. de Buitrago, S. Jimenez-Baranda, C. Gomez-Mouton, C. Martinez-A, and S. Manes Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface J. Cell Sci., May 1, 2004; 117(9): 1847 - 1857. [Abstract] [Full Text] [PDF]

				Y. Noguchi, T. Sato, M. Hirata, T. Hara, K. Ohama, and A. Ito Identification and Characterization of Extracellular Matrix Metalloproteinase Inducer in Human Endometrium during the Menstrual Cycle in Vivo and in Vitro J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 6063 - 6072. [Abstract] [Full Text] [PDF]

				T. Betsuyaku, M. Tanino, K. Nagai, Y. Nasuhara, M. Nishimura, and R. M. Senior Extracellular Matrix Metalloproteinase Inducer Is Increased in Smokers' Bronchoalveolar Lavage Fluid Am. J. Respir. Crit. Care Med., July 15, 2003; 168(2): 222 - 227. [Abstract] [Full Text] [PDF]

				T. Betsuyaku, K. Kadomatsu, G. L. Griffin, T. Muramatsu, and R. M. Senior Increased Basigin in Bleomycin-Induced Lung Injury Am. J. Respir. Cell Mol. Biol., May 1, 2003; 28(5): 600 - 606. [Abstract] [Full Text] [PDF]

				T. C. Major, L. Liang, X. Lu, W. Rosebury, and T. M.A. Bocan Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Is Induced Upon Monocyte Differentiation and Is Expressed in Human Atheroma Arterioscler. Thromb. Vasc. Biol., July 1, 2002; 22(7): 1200 - 1207. [Abstract] [Full Text] [PDF]

				S. Zucker, M. Hymowitz, E. E. Rollo, R. Mann, C. E. Conner, J. Cao, H. D. Foda, D. C. Tompkins, and B. P. Toole Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer Am. J. Pathol., June 1, 2001; 158(6): 1921 - 1928. [Abstract] [Full Text] [PDF]