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Advances in Brief |
in Somatic and Meiotic Cells1
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 [F. B. J., D. B. L., R. A. M., L. G.]; Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts 02115 [F. B. J.]; Division of Hematology-Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 [R. A. M.]; Laboratory of Molecular Genetics, New York Blood Center, New York, New York 10021 [N. F. N.]; Whitehead Institute, Cambridge, Massachusetts 02142 [M-A. M., R. J.]; Beth Israel/Deaconess Medical Center, Boston, Massachusetts 02215 [W. D., Y. Y.]; and Laboratory of Cancer Susceptibility, Memorial Sloan-Kettering Cancer Research Center, New York, New York 10021 [N. A. E.]
Bloom syndrome (BS) is characterized by genomic instability and cancer
susceptibility caused by defects in BLM, a DNA helicase of the
RecQ-family (J. German and N. A. Ellis, The Genetic Basis of Human
Cancer, pp. 301–316, 1998). RecQ helicases and topoisomerase III
proteins interact physically and functionally in yeast (S. Gangloff
et al., Mol. Cell. Biol., 14: 8391–8398,
1994) and in Escherichia coli can function together to
enable passage of double-stranded DNA (F. G. Harmon et
al., Mol. Cell, 3: 611–620, 1999). We
demonstrate in somatic and meiotic human cells an association between
BLM and topoisomerase III
. These proteins colocalize in
promyelocytic leukemia protein nuclear bodies, and this localization is
disrupted in BS cells. Thus, mechanisms by which RecQ helicases and
topoisomerase III proteins cooperate to maintain genomic stability in
model organisms likely apply to humans.
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H. W. Mankouri and I. D. Hickson Top3 Processes Recombination Intermediates and Modulates Checkpoint Activity after DNA Damage Mol. Biol. Cell, October 1, 2006; 17(10): 4473 - 4483. [Abstract] [Full Text] [PDF]
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J. A. Cobb and L. Bjergbaek RecQ helicases: lessons from model organisms Nucleic Acids Res., September 10, 2006; 34(15): 4106 - 4114. [Abstract] [Full Text] [PDF]
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L. Wu, C. Z. Bachrati, J. Ou, C. Xu, J. Yin, M. Chang, W. Wang, L. Li, G. W. Brown, and I. D. Hickson BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. PNAS, March 14, 2006; 103(11): 4068 - 4073. [Abstract] [Full Text] [PDF]
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V. A. Rao, A. M. Fan, L. Meng, C. F. Doe, P. S. North, I. D. Hickson, and Y. Pommier Phosphorylation of BLM, Dissociation from Topoisomerase III{alpha}, and Colocalization with {gamma}-H2AX after Topoisomerase I-Induced Replication Damage Mol. Cell. Biol., October 15, 2005; 25(20): 8925 - 8937. [Abstract] [Full Text] [PDF]
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S. Sharma, J. A. Sommers, S. Choudhary, J. K. Faulkner, S. Cui, L. Andreoli, L. Muzzolini, A. Vindigni, and R. M. Brosh Jr. Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1 J. Biol. Chem., July 29, 2005; 280(30): 28072 - 28084. [Abstract] [Full Text] [PDF]
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K. M. Doherty, S. Sharma, L. A. Uzdilla, T. M. Wilson, S. Cui, A. Vindigni, and R. M. Brosh Jr. RECQ1 Helicase Interacts with Human Mismatch Repair Factors That Regulate Genetic Recombination J. Biol. Chem., July 29, 2005; 280(30): 28085 - 28094. [Abstract] [Full Text] [PDF]
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R.-b. Guo, P. Rigolet, L. Zargarian, S. Fermandjian, and X. G. Xi Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase Nucleic Acids Res., June 1, 2005; 33(10): 3109 - 3124. [Abstract] [Full Text] [PDF]
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J. L. Plank, S. H. Chu, J. R. Pohlhaus, T. Wilson-Sali, and T.-s. Hsieh Drosophila melanogaster Topoisomerase III{alpha} Preferentially Relaxes a Positively or Negatively Supercoiled Bubble Substrate and Is Essential during Development J. Biol. Chem., February 4, 2005; 280(5): 3564 - 3573. [Abstract] [Full Text] [PDF]
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C. Wicky, A. Alpi, M. Passannante, A. Rose, A. Gartner, and F. Muller Multiple Genetic Pathways Involving the Caenorhabditis elegans Bloom's Syndrome Genes him-6, rad-51, and top-3 Are Needed To Maintain Genome Stability in the Germ Line Mol. Cell. Biol., June 1, 2004; 24(11): 5016 - 5027. [Abstract] [Full Text] [PDF]
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S. Sharma, J. A. Sommers, L. Wu, V. A. Bohr, I. D. Hickson, and R. M. Brosh Jr. Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein J. Biol. Chem., March 12, 2004; 279(11): 9847 - 9856. [Abstract] [Full Text] [PDF]
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H. Gao, X.-B. Chen, and C. H. McGowan Mus81 Endonuclease Localizes to Nucleoli and to Regions of DNA Damage in Human S-phase Cells Mol. Biol. Cell, December 1, 2003; 14(12): 4826 - 4834. [Abstract] [Full Text] [PDF]
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B. Cheng, C.-X. Zhu, C. Ji, A. Ahumada, and Y.-C. Tse-Dinh Direct Interaction between Escherichia coli RNA Polymerase and the Zinc Ribbon Domains of DNA Topoisomerase I J. Biol. Chem., August 15, 2003; 278(33): 30705 - 30710. [Abstract] [Full Text] [PDF]
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A. R. Meetei, S. Sechi, M. Wallisch, D. Yang, M. K. Young, H. Joenje, M. E. Hoatlin, and W. Wang A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome Mol. Cell. Biol., May 15, 2003; 23(10): 3417 - 3426. [Abstract] [Full Text] [PDF]
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S. A. Bastin-Shanower, W. M. Fricke, J. R. Mullen, and S. J. Brill The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10 Mol. Cell. Biol., May 15, 2003; 23(10): 3487 - 3496. [Abstract] [Full Text] [PDF]
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W. Wang, M. Seki, Y. Narita, T. Nakagawa, A. Yoshimura, M. Otsuki, Y.-i. Kawabe, S. Tada, H. Yagi, Y. Ishii, et al. Functional Relation among RecQ Family Helicases RecQL1, RecQL5, and BLM in Cell Growth and Sister Chromatid Exchange Formation Mol. Cell. Biol., May 15, 2003; 23(10): 3527 - 3535. [Abstract] [Full Text] [PDF]
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L. V. Laursen, E. Ampatzidou, A. H. Andersen, and J. M. Murray Role for the Fission Yeast RecQ Helicase in DNA Repair in G2 Mol. Cell. Biol., May 15, 2003; 23(10): 3692 - 3705. [Abstract] [Full Text] [PDF]
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 F. Cortes and N. Pastor Induction of endoreduplication by topoisomerase II catalytic inhibitors Mutagenesis, March 1, 2003; 18(2): 105 - 112. [Abstract] [Full Text] [PDF]
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D. J. Stavropoulos, P. S. Bradshaw, X. Li, I. Pasic, K. Truong, M. Ikura, M. Ungrin, and M. S. Meyn The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis Hum. Mol. Genet., December 1, 2002; 11(25): 3135 - 3144. [Abstract] [Full Text] [PDF]
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L. Wu and I. D. Hickson The Bloom's syndrome helicase stimulates the activity of human topoisomerase III{alpha} Nucleic Acids Res., November 15, 2002; 30(22): 4823 - 4829. [Abstract] [Full Text] [PDF]
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A. Franchitto and P. Pichierri Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex Hum. Mol. Genet., October 1, 2002; 11(20): 2447 - 2453. [Abstract] [Full Text] [PDF]
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Y. Wang, Y. L. Lyu, and J. C. Wang Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus PNAS, September 17, 2002; 99(19): 12114 - 12119. [Abstract] [Full Text] [PDF]
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M. D. Huber, D. C. Lee, and N. Maizels G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition Nucleic Acids Res., September 15, 2002; 30(18): 3954 - 3961. [Abstract] [Full Text] [PDF]
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 P. B. Moens, N. K. Kolas, M. Tarsounas, E. Marcon, P. E. Cohen, and B. Spyropoulos The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination J. Cell Sci., April 15, 2002; 115(8): 1611 - 1622. [Abstract] [Full Text] [PDF]
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A. Franchitto and P. Pichierri Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest J. Cell Biol., April 1, 2002; 157(1): 19 - 30. [Abstract] [Full Text] [PDF]
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S. Dutertre, R. Sekhri, L. A. Tintignac, R. Onclercq-Delic, B. Chatton, C. Jaulin, and M. Amor-Gueret Dephosphorylation and Subcellular Compartment Change of the Mitotic Bloom's Syndrome DNA Helicase in Response to Ionizing Radiation J. Biol. Chem., February 15, 2002; 277(8): 6280 - 6286. [Abstract] [Full Text] [PDF]
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R. K. Chakraverty, J. M. Kearsey, T. J. Oakley, M. Grenon, M.-A. de la Torre Ruiz, N. F. Lowndes, and I. D. Hickson Topoisomerase III Acts Upstream of Rad53p in the S-Phase DNA Damage Checkpoint Mol. Cell. Biol., November 1, 2001; 21(21): 7150 - 7162. [Abstract] [Full Text] [PDF]
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V. Kaliraman, J. R. Mullen, W. M. Fricke, S. A. Bastin-Shanower, and S. J. Brill Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease Genes & Dev., October 15, 2001; 15(20): 2730 - 2740. [Abstract] [Full Text] [PDF]
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P. Hu, S. Beresten, A. van Brabant, T.-Z. Ye, P.-P. Pandolfi, F. B. Johnson, L. Guarente, and N. A. Ellis Evidence for BLM and Topoisomerase III{{alpha}} interaction in genomic stability Hum. Mol. Genet., June 1, 2001; 10(12): 1287 - 1298. [Abstract] [Full Text] [PDF]
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K. Y. Kwan and J. C. Wang Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan PNAS, April 25, 2001; (2001) 101132498. [Abstract] [Full Text]
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P. P. Pandolfi Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia Hum. Mol. Genet., April 1, 2001; 10(7): 769 - 775. [Abstract] [Full Text] [PDF]
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 J. R. Mullen, V. Kaliraman, S. S. Ibrahim, and S. J. Brill Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae Genetics, January 1, 2001; 157(1): 103 - 118. [Abstract] [Full Text]
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F. Hartung, H. Plchova, and H. Puchta Molecular characterisation of RecQ homologues in Arabidopsis thaliana Nucleic Acids Res., November 1, 2000; 28(21): 4275 - 4282. [Abstract] [Full Text] [PDF]
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S. Liao, J. Graham, and H. Yan The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication Genes & Dev., October 15, 2000; 14(20): 2570 - 2575. [Abstract] [Full Text]
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 D. B. Lombard and L. Guarente Nijmegen Breakage Syndrome Disease Protein and MRE11 at PML Nuclear Bodies and Meiotic Telomeres Cancer Res., May 1, 2000; 60(9): 2331 - 2334. [Abstract] [Full Text]
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G. Langland, J. Kordich, J. Creaney, K. H. Goss, K. Lillard-Wetherell, K. Bebenek, T. A. Kunkel, and J. Groden The Bloom's Syndrome Protein (BLM) Interacts with MLH1 but Is Not Required for DNA Mismatch Repair J. Biol. Chem., August 3, 2001; 276(32): 30031 - 30035. [Abstract] [Full Text] [PDF]
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W. M. Fricke, V. Kaliraman, and S. J. Brill Mapping the DNA Topoisomerase III Binding Domain of the Sgs1 DNA Helicase J. Biol. Chem., March 16, 2001; 276(12): 8848 - 8855. [Abstract] [Full Text] [PDF]
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K. Y. Kwan and J. C. Wang Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan PNAS, May 8, 2001; 98(10): 5717 - 5721. [Abstract] [Full Text] [PDF]
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A. Franchitto and P. Pichierri Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest J. Cell Biol., April 1, 2002; 157(1): 19 - 30. [Abstract] [Full Text] [PDF]
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