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Laboratory of Pathology, Aichi Cancer Center Research Institute, Aichi 464-8681 [N. S., Y. I., K-I. I., H. N., T. T., K. N., M. T.]; Department of Gastrointestinal Surgery, Postgraduate School of Medicine, University of Tokyo, Tokyo 112-8688 [N. S., K. N., M. K., S. K., K-I. I.]; and First Department of Surgery [A. S.], and Department of Laboratory Medicine [T. K.], Shinshu University, Matsumoto 390-8621, Japan
To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.
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