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[Cancer Research 60, 2085-2089, April 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Sulindac and Exisulind Exhibit a Significant Antiproliferative Effect and Induce Apoptosis in Human Hepatocellular Carcinoma Cell Lines

Md Atiqur Rahman1, Dipok Kumar Dhar, Reiko Masunaga, Akira Yamanoi, Hitoshi Kohno and Naofumi Nagasue

Second Department of Surgery, Shimane Medical University, Izumo 693, Japan

This is the first report enumerating a superb antiproliferative effect of both sulindac and exisulind on hepatocellular cancer cell lines. The growth inhibition and cytotoxicity of sulindac in human hepatocellular carcinoma cell lines HepG2, Huh-7, and KYN-2 were investigated by studying cell growth, cell cycle distribution, and induction of apoptosis. In the presence of sulindac, there was a marked time- and dose-dependent decrease in cell proliferation and viability. Also, exisulind exhibited a similar growth-inhibitory effect on the KYN-2 cell line. The findings of this study suggest that sulindac exhibits a growth-inhibitory effect on human hepatocellular carcinoma cell lines; therefore, these drugs might serve as an effective tool for hepatocellular carcinoma chemoprevention.




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