Cancer Research Targets Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, T.
Right arrow Articles by Farrar, W. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, T.
Right arrow Articles by Farrar, W. L.
[Cancer Research 60, 2132-2135, April 15, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Interleukin 6 Activates Androgen Receptor-mediated Gene Expression through a Signal Transducer and Activator of Transcription 3-dependent Pathway in LNCaP Prostate Cancer Cells1

Taosheng Chen2, Li Hua Wang and William L. Farrar

Intramural Research Support Program, Science Applications International Corporation-Frederick [T. C.] and Cytokine Molecular Mechanisms Section, Laboratory of Molecular Immunoregulation [L. H. W., W. L. F.], National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702

Interleukin 6 (IL-6) is a cytokine that regulates not only immune and inflammatory responses but also the growth of some tumors, including prostate carcinomas. IL-6 signals through Janus kinase, signal transducer and activator of transcription 3 (STAT3), and mitogen-activated protein kinase and is also able to induce androgen receptor (AR)-mediated gene activation in prostate cancer, which is an important process in prostate cancer androgen-independent progression. We now show that IL-6-induced AR-mediated gene activation requires the activation of STAT3 by IL-6 in LNCaP prostate cancer cells. In particular, STAT3 associates with AR in an androgen-independent but IL-6-dependent manner. Inhibition of STAT3 rather than mitogen-activated protein kinase results in inhibition of AR-mediated gene activation in response to IL-6. These findings not only identify STAT3 as an important signaling molecule required for IL-6-signaling to induce AR-mediated gene activation in prostate carcinoma cells but also reveal the importance of activated STAT3 in human tumor development and progression.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
J. Y. Chun, N. Nadiminty, S. Dutt, W. Lou, J. C. Yang, H.-J. Kung, C. P. Evans, and A. C. Gao
Interleukin-6 Regulates Androgen Synthesis in Prostate Cancer Cells
Clin. Cancer Res., August 1, 2009; 15(15): 4815 - 4822.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. J. Vander Griend, L. Antony, S. L. Dalrymple, Y. Xu, S. B. Christensen, S. R. Denmeade, and J. T. Isaacs
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells
Mol. Cancer Ther., May 1, 2009; 8(5): 1340 - 1349.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
K. Malinowska, H. Neuwirt, I. T Cavarretta, J. Bektic, H. Steiner, H. Dietrich, P. L Moser, D. Fuchs, A. Hobisch, and Z. Culig
Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor
Endocr. Relat. Cancer, March 1, 2009; 16(1): 155 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
S. Feng, Q. Tang, M. Sun, J. Y. Chun, C. P. Evans, and A. C. Gao
Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
Mol. Cancer Ther., March 1, 2009; 8(3): 665 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. Zoubeidi, J. Rocha, F. Z. Zouanat, L. Hamel, E. Scarlata, A. G. Aprikian, and S. Chevalier
The Fer Tyrosine Kinase Cooperates with Interleukin-6 to Activate Signal Transducer and Activator of Transcription 3 and Promote Human Prostate Cancer Cell Growth
Mol. Cancer Res., January 1, 2009; 7(1): 142 - 155.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Lin, J. Wu, H. Dong, D. Bouck, F.-Y. Zeng, and T. Chen
Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediated CYP3A4 Gene Expression in HepG2 Liver Carcinoma Cells
J. Biol. Chem., November 7, 2008; 283(45): 30650 - 30657.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
K.-H. Tsui, T.-H. Feng, C.-M. Lin, P.-L. Chang, and H.-H. Juang
Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antigen Expression in Human Prostatic Carcinoma Cells
J Androl, November 1, 2008; 29(6): 661 - 668.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Sharifi, E. M. Hurt, S. B. Thomas, and W. L. Farrar
Effects of Manganese Superoxide Dismutase Silencing on Androgen Receptor Function and Gene Regulation: Implications for Castration-Resistant Prostate Cancer
Clin. Cancer Res., October 1, 2008; 14(19): 6073 - 6080.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H. Hu, H.-J. Lee, C. Jiang, J. Zhang, L. Wang, Y. Zhao, Q. Xiang, E.-O. Lee, S.-H. Kim, and J. Lu
Penta-1,2,3,4,6-O-galloyl-{beta}-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
Mol. Cancer Ther., September 1, 2008; 7(9): 2681 - 2691.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. S. Lyons, S. Rao, W. Balkan, J. Faysal, C. A. Maiorino, and K. L. Burnstein
Ligand-Independent Activation of Androgen Receptors by Rho GTPase Signaling in Prostate Cancer
Mol. Endocrinol., March 1, 2008; 22(3): 597 - 608.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S.-H. Tan, A. Dagvadorj, F. Shen, L. Gu, Z. Liao, J. Abdulghani, Y. Zhang, E. P. Gelmann, T. Zellweger, Z. Culig, et al.
Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells
Cancer Res., January 1, 2008; 68(1): 236 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
H. Neuwirt, M. Puhr, I. T Cavarretta, M. Mitterberger, A. Hobisch, and Z. Culig
Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion
Endocr. Relat. Cancer, December 1, 2007; 14(4): 1007 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. V. Heemers and D. J. Tindall
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
Endocr. Rev., December 1, 2007; 28(7): 778 - 808.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. G. Nickols and P. B. Dervan
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide
PNAS, June 19, 2007; 104(25): 10418 - 10423.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Azare, K. Leslie, H. Al-Ahmadie, W. Gerald, P. H. Weinreb, S. M. Violette, and J. Bromberg
Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin {beta}6
Mol. Cell. Biol., June 15, 2007; 27(12): 4444 - 4453.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. C.K. Leung and J.-H. Choi
Endocrine signaling in ovarian surface epithelium and cancer
Hum. Reprod. Update, March 1, 2007; 13(2): 143 - 162.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. G. Uzzo, P. L. Crispen, K. Golovine, P. Makhov, E. M. Horwitz, and V. M. Kolenko
Diverse effects of zinc on NF-{kappa}B and AP-1 transcription factors: implications for prostate cancer progression
Carcinogenesis, October 1, 2006; 27(10): 1980 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
R. P Singh and R. Agarwal
Mechanisms of action of novel agents for prostate cancer chemoprevention.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 751 - 778.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Maggio, S. Basaria, A. Ble, F. Lauretani, S. Bandinelli, G. P. Ceda, G. Valenti, S. M. Ling, and L. Ferrucci
Correlation between Testosterone and the Inflammatory Marker Soluble Interleukin-6 Receptor in Older Men
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 345 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
V. E. MacRae, C. Farquharson, and S. F. Ahmed
The pathophysiology of the growth plate in juvenile idiopathic arthritis
Rheumatology, January 1, 2006; 45(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Chen, M. Nomura, H. Morinaga, E. Matsubara, T. Okabe, K. Goto, T. Yanase, H. Zheng, J. Lu, and H. Nawata
Modulation of Androgen Receptor Transactivation by FoxH1: A NEWLY IDENTIFIED ANDROGEN RECEPTOR COREPRESSOR
J. Biol. Chem., October 28, 2005; 280(43): 36355 - 36363.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
K-M Rau, H-Y Kang, T-L Cha, S A Miller, and M-C Hung
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers
Endocr. Relat. Cancer, September 1, 2005; 12(3): 511 - 532.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Yang, M.-W. Chen, S. Terry, F. Vacherot, D. K. Chopin, D. L. Bemis, J. Kitajewski, M. C. Benson, Y. Guo, and R. Buttyan
A Human- and Male-Specific Protocadherin that Acts through the Wnt Signaling Pathway to Induce Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Cancer Res., June 15, 2005; 65(12): 5263 - 5271.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
Z Culig, H Steiner, G Bartsch, and A Hobisch
Mechanisms of endocrine therapy-responsive and -unresponsive prostate tumours
Endocr. Relat. Cancer, June 1, 2005; 12(2): 229 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. J. George, S. Halabi, T. F. Shepard, B. Sanford, N. J. Vogelzang, E. J. Small, and P. W. Kantoff
The Prognostic Significance of Plasma Interleukin-6 Levels in Patients with Metastatic Hormone-Refractory Prostate Cancer: Results from Cancer and Leukemia Group B 9480
Clin. Cancer Res., March 1, 2005; 11(5): 1815 - 1820.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. B. Wetherill, N. L. Fisher, A. Staubach, M. Danielsen, R. W. de Vere White, and K. E. Knudsen
Xenoestrogen Action in Prostate Cancer: Pleiotropic Effects Dependent on Androgen Receptor Status
Cancer Res., January 1, 2005; 65(1): 54 - 65.
[Abstract] [Full Text] [PDF]

Home page
 Integr Cancer TherHome page
M. F. McCarty
Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy
Integr Cancer Ther, December 1, 2004; 3(4): 349 - 380.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
H. Li, T. J. Ahonen, K. Alanen, J. Xie, M. J. LeBaron, T. G. Pretlow, E. L. Ealley, Y. Zhang, M. Nurmi, B. Singh, et al.
Activation of Signal Transducer and Activator of Transcription 5 in Human Prostate Cancer Is Associated with High Histological Grade
Cancer Res., July 15, 2004; 64(14): 4774 - 4782.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Tong and H.-H. Tai
Synergistic Induction of the Nicotinamide Adenine Dinucleotide-Linked 15-Hydroxyprostaglandin Dehydrogenase by an Androgen and Interleukin-6 or Forskolin in Human Prostate Cancer Cells
Endocrinology, May 1, 2004; 145(5): 2141 - 2147.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor in Prostate Cancer
Endocr. Rev., April 1, 2004; 25(2): 276 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
B. E. Barton, J. G. Karras, T. F. Murphy, A. Barton, and H. F-S. Huang
Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines
Mol. Cancer Ther., January 1, 2004; 3(1): 11 - 20.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Y. Pan, J.-S. Zhang, M. H. Gazi, and C. Y. F. Young
The Cyclooxygenase 2-specific Nonsteroidal Anti-inflammatory Drugs Celecoxib and Nimesulide Inhibit Androgen Receptor Activity via Induction of c-Jun in Prostate Cancer Cells
Cancer Epidemiol. Biomarkers Prev., August 1, 2003; 12(8): 769 - 774.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. V. Litvinov, A. M. De Marzo, and J. T. Isaacs
Is the Achilles' Heel for Prostate Cancer Therapy a Gain of Function in Androgen Receptor Signaling?
J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 2972 - 2982.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. O. Lee, W. Lou, M. Hou, F. de Miguel, L. Gerber, and A. C. Gao
Interleukin-6 Promotes Androgen-independent Growth in LNCaP Human Prostate Cancer Cells
Clin. Cancer Res., January 1, 2003; 9(1): 370 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. B. Mora, R. Buettner, J. Seigne, J. Diaz, N. Ahmad, R. Garcia, T. Bowman, R. Falcone, R. Fairclough, A. Cantor, et al.
Constitutive Activation of Stat3 in Human Prostate Tumors and Cell Lines: Direct Inhibition of Stat3 Signaling Induces Apoptosis of Prostate Cancer Cells
Cancer Res., November 15, 2002; 62(22): 6659 - 6666.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. D. Debes, L. J. Schmidt, H. Huang, and D. J. Tindall
p300 Mediates Androgen-independent Transactivation of the Androgen Receptor by Interleukin 6
Cancer Res., October 15, 2002; 62(20): 5632 - 5636.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Godoy-Tundidor, A. Hobisch, K. Pfeil, G. Bartsch, and Z. Culig
Acquisition of Agonistic Properties of Nonsteroidal Antiandrogens after Treatment with Oncostatin M in Prostate Cancer Cells
Clin. Cancer Res., July 1, 2002; 8(7): 2356 - 2361.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor (AR) Coregulators: An Overview
Endocr. Rev., April 1, 2002; 23(2): 175 - 200.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Ueda, N. Bruchovsky, and M. D. Sadar
Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways
J. Biol. Chem., February 22, 2002; 277(9): 7076 - 7085.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L.-F. Lee, J. Guan, Y. Qiu, and H.-J. Kung
Neuropeptide-Induced Androgen Independence in Prostate Cancer Cells: Roles of Nonreceptor Tyrosine Kinases Etk/Bmx, Src, and Focal Adhesion Kinase
Mol. Cell. Biol., December 15, 2001; 21(24): 8385 - 8397.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. Giri, M. Ozen, and M. Ittmann
Interleukin-6 Is an Autocrine Growth Factor in Human Prostate Cancer
Am. J. Pathol., December 1, 2001; 159(6): 2159 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. Cinar, K. S. Koeneman, M. Edlund, G. S. Prins, H. E. Zhau, and L. W. K. Chung
Androgen Receptor Mediates the Reduced Tumor Growth, Enhanced Androgen Responsiveness, and Selected Target Gene Transactivation in a Human Prostate Cancer Cell Line
Cancer Res., October 1, 2001; 61(19): 7310 - 7317.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Hobisch, R. Ramoner, D. Fuchs, S. Godoy-Tundidor, G. Bartsch, H. Klocker, and Z. Culig
Prostate Cancer Cells (LNCaP) Generated after Long-Term Interleukin 6 (IL-6) Treatment Express IL-6 and Acquire an IL-6 Partially Resistant Phenotype
Clin. Cancer Res., September 1, 2001; 7(9): 2941 - 2948.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D.-L. Lin, M. C. Whitney, Z. Yao, and E. T. Keller
Interleukin-6 Induces Androgen Responsiveness in Prostate Cancer Cells through Up-Regulation of Androgen Receptor Expression
Clin. Cancer Res., June 1, 2001; 7(6): 1773 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. L. Campbell, Z. Jiang, D. M. F. Savarese, and T. M. Savarese
Increased Expression of the Interleukin-11 Receptor and Evidence of STAT3 Activation in Prostate Carcinoma
Am. J. Pathol., January 1, 2001; 158(1): 25 - 32.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.