Cancer Research Landon Prizes for Basic and Translational Cancer Research AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lombard, D. B.
Right arrow Articles by Guarente, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lombard, D. B.
Right arrow Articles by Guarente, L.
[Cancer Research 60, 2331-2334, May 1, 2000]
© 2000 American Association for Cancer Research

Advances in Brief

Nijmegen Breakage Syndrome Disease Protein and MRE11 at PML Nuclear Bodies and Meiotic Telomeres1

David B. Lombard and Leonard Guarente2

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Nijmegen breakage syndrome is a disease characterized by immunodeficiency, genomic instability, and cancer susceptibility. The gene product defective in Nijmegen breakage syndrome, p95, associates with two other proteins, MRE11 and RAD50. Here we demonstrate that in the absence of DNA damage, a portion of p95 and MRE11 is concentrated in PML nuclear bodies (NBs); MRE11 localization to the NBs is p95-dependent. In mammalian meiocytes, these proteins are specifically found at the telomeres. These results implicate the NBs in the maintenance of genomic stability and suggest that p95 and MRE11 may have roles in telomere maintenance in mammals, analogous to the role their homologues play in yeast.




This article has been cited by other articles:


Home page
 J. Virol.Home page
A. J. Ullman and P. Hearing
Cellular Proteins PML and Daxx Mediate an Innate Antiviral Defense Antagonized by the Adenovirus E4 ORF3 Protein
J. Virol., August 1, 2008; 82(15): 7325 - 7335.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. H. Luo, K. Rosenke, K. Czornak, and E. A. Fortunato
Human Cytomegalovirus Disrupts both Ataxia Telangiectasia Mutated Protein (ATM)- and ATM-Rad3-Related Kinase-Mediated DNA Damage Responses during Lytic Infection
J. Virol., February 15, 2007; 81(4): 1934 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Yang, J.-H. Jeong, A. L. Brown, C.-H. Lee, P. P. Pandolfi, J. H. Chung, and M. K. Kim
Promyelocytic Leukemia Activates Chk2 by Mediating Chk2 Autophosphorylation
J. Biol. Chem., September 8, 2006; 281(36): 26645 - 26654.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. J. Luciani, D. Depetris, Y. Usson, C. Metzler-Guillemain, C. Mignon-Ravix, M. J. Mitchell, A. Megarbane, P. Sarda, H. Sirma, A. Moncla, et al.
PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase
J. Cell Sci., June 15, 2006; 119(12): 2518 - 2531.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
P. E. Cohen, S. E. Pollack, and J. W. Pollard
Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals
Endocr. Rev., June 1, 2006; 27(4): 398 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. J. Chiang, M.-L. Nguyen, S. Gurunathan, P. Kaminker, L. Tessarollo, J. Campisi, and R. J. Hodes
Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice.
Mol. Cell. Biol., March 1, 2006; 26(6): 2037 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. H. Stracker, D. V. Lee, C. T. Carson, F. D. Araujo, D. A. Ornelles, and M. D. Weitzman
Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins
J. Virol., June 1, 2005; 79(11): 6664 - 6673.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. Eladad, T.-Z. Ye, P. Hu, M. Leversha, S. Beresten, M. J. Matunis, and N. A. Ellis
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification
Hum. Mol. Genet., May 15, 2005; 14(10): 1351 - 1365.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. W. Ching, G. Dellaire, C. H. Eskiw, and D. P. Bazett-Jones
PML bodies: a meeting place for genomic loci?
J. Cell Sci., March 1, 2005; 118(5): 847 - 854.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Nabetani, O. Yokoyama, and F. Ishikawa
Localization of hRad9, hHus1, hRad1, and hRad17 and Caffeine-sensitive DNA Replication at the Alternative Lengthening of Telomeres-associated Promyelocytic Leukemia Body
J. Biol. Chem., June 11, 2004; 279(24): 25849 - 25857.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S. Kurki, L. Latonen, and M. Laiho
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
J. Cell Sci., October 1, 2003; 116(19): 3917 - 3925.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
A. R. Davalos and J. Campisi
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
J. Cell Biol., September 29, 2003; 162(7): 1197 - 1209.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. M. Cerosaletti and P. Concannon
Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation
J. Biol. Chem., June 6, 2003; 278(24): 21944 - 21951.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Wu, X. Jiang, W.-H. Lee, and P.-L. Chen
Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1
Cancer Res., May 15, 2003; 63(10): 2589 - 2595.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. de Jager and R. Kanaar
Genome instability and Rad50S: subtle yet severe
Genes & Dev., September 1, 2002; 16(17): 2173 - 2178.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
C. F. Bender, M. L. Sikes, R. Sullivan, L. E. Huye, M. M. Le Beau, D. B. Roth, O. K. Mirzoeva, E. M. Oltz, and J. H. J. Petrini
Cancer predisposition and hematopoietic failure in Rad50S/S mice
Genes & Dev., September 1, 2002; 16(17): 2237 - 2251.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
T. M. Nakamura, B. A. Moser, and P. Russell
Telomere Binding of Checkpoint Sensor and DNA Repair Proteins Contributes to Maintenance of Functional Fission Yeast Telomeres
Genetics, August 1, 2002; 161(4): 1437 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. Hu, S. Beresten, A. van Brabant, T.-Z. Ye, P.-P. Pandolfi, F. B. Johnson, L. Guarente, and N. A. Ellis
Evidence for BLM and Topoisomerase III{{alpha}} interaction in genomic stability
Hum. Mol. Genet., June 1, 2001; 10(12): 1287 - 1298.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
E. M. Taylor, J. S. Moghraby, J. H. Lees, B. Smit, P. B. Moens, and A. R. Lehmann
Characterization of a Novel Human SMC Heterodimer Homologous to the Schizosaccharomyces pombe Rad18/Spr18 Complex
Mol. Biol. Cell, June 1, 2001; 12(6): 1583 - 1594.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. P. Pandolfi
Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia
Hum. Mol. Genet., April 1, 2001; 10(7): 769 - 775.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. de Jager, M. L. G. Dronkert, M. Modesti, C. E. M. T. Beerens, R. Kanaar, and D. C. van Gent
DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways
Nucleic Acids Res., March 15, 2001; 29(6): 1317 - 1325.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. McIlrath, S. D. Bouffler, E. Samper, A. Cuthbert, A. Wojcik, I. Szumiel, P. E. Bryant, A. C. Riches, A. Thompson, M. A. Blasco, et al.
Telomere Length Abnormalities in Mammalian Radiosensitive Cells
Cancer Res., February 1, 2001; 61(3): 912 - 915.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
O. K. Mirzoeva and J. H. J. Petrini
DNA Damage-Dependent Nuclear Dynamics of the Mre11 Complex
Mol. Cell. Biol., January 1, 2001; 21(1): 281 - 288.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2000 by the American Association for Cancer Research.