| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Experimental Therapeutics |
Developmental Therapeutics Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute [J. B., A. S. C., Y. N.], and Navy Medical Oncology, National Naval Medical Center [P. A. D.], Bethesda, Maryland 20889
To evaluate the role of Akt/PKB in non-small cell lung cancer (NSCLC) survival, we analyzed NSCLC cell lines that differed in tumor histology as well as p53, Rb, and K-ras status. Constitutive Akt/protein kinase B (PKB) activity was demonstrated in 16 of 17 cell lines by maintenance of S473 phosphorylation with serum deprivation. Additional analysis of five of 2these NSCLC lines revealed that phosphorylation of S473 and T308 correlated with in vitro kinase activity. Akt/PKB activation was phosphatidylinositol 3-kinase-dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin inhibited Akt/PKB phosphorylation, Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB. To test whether Akt/PKB activity promoted therapeutic resistance, LY294002 was added with individual chemotherapeutic agents or irradiation. LY294002 greatly potentiated chemotherapy-induced apoptosis in cells with high Akt/PKB levels, but did not significantly increase chemotherapy-induced apoptosis in cells with low Akt/PKB levels. Combined with radiation in cells with active Akt/PKB, LY294002 additively increased apoptosis and inhibited clonogenic growth. These results were extended with transiently transfected Akt/PKB mutants. Transfecting dominant negative Akt/PKB decreased Akt/PKB activity and increased basal apoptosis as well as chemotherapy- and irradiation-induced apoptosis only in cells with high Akt/PKB activity. Conversely, transfecting constitutively active Akt/PKB into cells with low Akt/PKB activity increased Akt/PKB activity and attenuated chemotherapy- and radiation-induced apoptosis. We therefore identify Akt/PKB as a constitutively active kinase that promotes survival of NSCLC cells and demonstrate that modulation of Akt/PKB activity by pharmacological or genetic approaches alters the cellular responsiveness to therapeutic modalities typically used to treat patients with NSCLC.
This article has been cited by other articles:
![]() |
G. Konstantinidou, E. A. Bey, A. Rabellino, K. Schuster, M. S. Maira, A. F. Gazdar, A. Amici, D. A. Boothman, and P. P. Scaglioni Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations Cancer Res., October 1, 2009; 69(19): 7644 - 7652. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. AL-SAAD, T. DONNEM, K. AL-SHIBLI, M. PERSSON, R. M. BREMNES, and L.-T. BUSUND Diverse Prognostic Roles of Akt Isoforms, PTEN and PI3K in Tumor Epithelial Cells and Stromal Compartment in Non-small Cell Lung Cancer Anticancer Res, October 1, 2009; 29(10): 4175 - 4183. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Markman, F. Atzori, J. Perez-Garcia, J. Tabernero, and J. Baselga Status of PI3K inhibition and biomarker development in cancer therapeutics Ann. Onc., August 27, 2009; (2009) mdp347v1. [Abstract] [Full Text] [PDF] |
||||
![]() |
X.-Y. Wang, A. Demelash, H. Kim, S. Jensen-Taubman, E. H. Dakir, L. Ozbun, M. J. Birrer, and R. I. Linnoila Matrilysin-1 Mediates Bronchiolization of Alveoli, a Potential Premalignant Change in Lung Cancer Am. J. Pathol., August 1, 2009; 175(2): 592 - 604. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-K. Hwang, H.-T. Lim, A. Minai-Tehrani, E.-S. Lee, J. Park, S. B. Park, G. R. Beck Jr., and M.-H. Cho Repeated Aerosol Delivery of Carboxyl-terminal Modulator Protein Suppresses Tumor in the Lungs of K-rasLA1 Mice Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1131 - 1140. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Brognard, M. Niederst, G. Reyes, N. Warfel, and A. C. Newton Common Polymorphism in the Phosphatase PHLPP2 Results in Reduced Regulation of Akt and Protein Kinase C J. Biol. Chem., May 29, 2009; 284(22): 15215 - 15223. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Wang, J. J. DiGiovanna, J. B. Stern, T. J. Hornyak, M. Raffeld, S. G. Khan, K.-S. Oh, M. C. Hollander, P. A. Dennis, and K. H. Kraemer Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas PNAS, April 14, 2009; 106(15): 6279 - 6284. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. M. Schittenhelm, C. Kollmannsberger, K. Oechsle, A. Harlow, J. Morich, F. Honecker, R. Kurek, S. Storkel, L. Kanz, C. L. Corless, et al. Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer Mol. Cancer Ther., March 1, 2009; 8(3): 481 - 489. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Qian, Y. Zou, J. S.M. Rahman, B. Lu, and P. P. Massion Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung Mol. Cancer Ther., January 1, 2009; 8(1): 101 - 109. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Jin, C.-X. Xu, H.-T. Lim, S.-J. Park, J.-Y. Shin, Y.-S. Chung, S.-C. Park, S.-H. Chang, H.-J. Youn, K.-H. Lee, et al. High Dietary Inorganic Phosphate Increases Lung Tumorigenesis and Alters Akt Signaling Am. J. Respir. Crit. Care Med., January 1, 2009; 179(1): 59 - 68. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-J. Kim, J.-Y. Byun, C.-H. Yun, I.-C. Park, K.-H. Lee, and S.-J. Lee c-Src-p38 Mitogen-Activated Protein Kinase Signaling Is Required for Akt Activation in Response to Ionizing Radiation Mol. Cancer Res., December 1, 2008; 6(12): 1872 - 1880. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-J. Kim, S.-Y. Choi, I.-C. Park, S.-G. Hwang, C. Kim, Y.-H. Choi, H. Kim, K.-H. Lee, and S.-J. Lee Opposing Roles of c-Jun NH2-Terminal Kinase and p38 Mitogen-Activated Protein Kinase in the Cellular Response to Ionizing Radiation in Human Cervical Cancer Cells Mol. Cancer Res., November 1, 2008; 6(11): 1718 - 1731. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Castro-Rivera, S. Ran, R. A. Brekken, and J. D. Minna Semaphorin 3B Inhibits the Phosphatidylinositol 3-Kinase/Akt Pathway through Neuropilin-1 in Lung and Breast Cancer Cells Cancer Res., October 15, 2008; 68(20): 8295 - 8303. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Serra, B. Markman, M. Scaltriti, P. J.A. Eichhorn, V. Valero, M. Guzman, M. L. Botero, E. Llonch, F. Atzori, S. Di Cosimo, et al. NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations Cancer Res., October 1, 2008; 68(19): 8022 - 8030. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. J. VanMeter, A. S. Rodriguez, E. D. Bowman, J. Jen, C. C. Harris, J. Deng, V. S. Calvert, A. Silvestri, C. Fredolini, V. Chandhoke, et al. Laser Capture Microdissection and Protein Microarray Analysis of Human Non-small Cell Lung Cancer: Differential Epidermal Growth Factor Receptor (EGPR) Phosphorylation Events Associated with Mutated EGFR Compared with Wild Type Mol. Cell. Proteomics, October 1, 2008; 7(10): 1902 - 1924. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Zheng, S. E. Morgan-Lappe, J. Yang, K. M. Bockbrader, D. Pamarthy, D. Thomas, S. W. Fesik, and Y. Sun Growth Inhibition and Radiosensitization of Glioblastoma and Lung Cancer Cells by Small Interfering RNA Silencing of Tumor Necrosis Factor Receptor-Associated Factor 2 Cancer Res., September 15, 2008; 68(18): 7570 - 7578. [Abstract] [Full Text] [PDF] |
||||
![]() |
C.-X. Xu, D. Jere, H. Jin, S.-H. Chang, Y.-S. Chung, J.-Y. Shin, J.-E. Kim, S.-J. Park, Y.-H. Lee, C.-H. Chae, et al. Poly(ester amine)-mediated, Aerosol-delivered Akt1 Small Interfering RNA Suppresses Lung Tumorigenesis Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 60 - 73. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Toulany, R. Kehlbach, U. Florczak, A. Sak, S. Wang, J. Chen, M. Lobrich, and H. P. Rodemann Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair Mol. Cancer Ther., July 1, 2008; 7(7): 1772 - 1781. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Gallo, G. F. Zannoni, I. De Stefano, M. Mosca, C. Ferlini, E. Mantuano, and G. Scambia Soy Phytochemicals Decrease Nonsmall Cell Lung Cancer Growth In Female Athymic Mice J. Nutr., July 1, 2008; 138(7): 1360 - 1364. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. C. Park, H. J. Zhang, E. S. Yao, C. J. Park, and M. J. Bissell {beta}1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts Cancer Res., June 1, 2008; 68(11): 4398 - 4405. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Wang, S. K. Kulp, D. Wang, C.-C. Yang, A. M. Sargeant, J.-H. Hung, Y. Kashida, M. Yamaguchi, G.-D. Chang, and C.-S. Chen Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors Cancer Res., April 15, 2008; 68(8): 2820 - 2830. [Abstract] [Full Text] [PDF] |
||||
![]() |
M.-E. Legrier, C.-P. H. Yang, H.-G. Yan, L. Lopez-Barcons, S. M. Keller, R. Perez-Soler, S. B. Horwitz, and H. M. McDaid Targeting Protein Translation in Human Non Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression Cancer Res., December 1, 2007; 67(23): 11300 - 11308. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Hohla, A. V. Schally, C. A. Kanashiro, S. Buchholz, B. Baker, C. Kannadka, A. Moder, E. Aigner, C. Datz, and G. Halmos Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt PNAS, November 20, 2007; 104(47): 18671 - 18676. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Tokuda, N. Fujita, T. Oh-hara, S. Sato, A. Kurata, R. Katayama, T. Itoh, T. Takenawa, K. Miyazono, and T. Tsuruo Casein Kinase 2 Interacting Protein-1, a Novel Akt Pleckstrin Homology Domain-Interacting Protein, Down-regulates PI3K/Akt Signaling and Suppresses Tumor Growth In vivo Cancer Res., October 15, 2007; 67(20): 9666 - 9676. [Abstract] [Full Text] [PDF] |
||||
![]() |
Q. Zhang, X. Tang, Z.-F. Zhang, R. Velikina, S. Shi, and A. D. Le Nicotine Induces Hypoxia-Inducible Factor-1{alpha} Expression in Human Lung Cancer Cells via Nicotinic Acetylcholine Receptor Mediated Signaling Pathways Clin. Cancer Res., August 15, 2007; 13(16): 4686 - 4694. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Toulany, M. Baumann, and H. P. Rodemann Stimulated PI3K-AKT Signaling Mediated through Ligand or Radiation-Induced EGFR Depends Indirectly, but not Directly, on Constitutive K-Ras Activity Mol. Cancer Res., August 1, 2007; 5(8): 863 - 872. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Engelman The Role of Phosphoinositide 3-Kinase Pathway Inhibitors in the Treatment of Lung Cancer Clin. Cancer Res., August 1, 2007; 13(15): 4637s - 4640s. [Abstract] [Full Text] [PDF] |
||||
![]() |
L.-Z. Liu, X.-D. Zhou, G. Qian, X. Shi, J. Fang, and B.-H. Jiang AKT1 Amplification Regulates Cisplatin Resistance in Human Lung Cancer Cells through the Mammalian Target of Rapamycin/p70S6K1 Pathway Cancer Res., July 1, 2007; 67(13): 6325 - 6332. [Abstract] [Full Text] [PDF] |
||||
![]() |
L Taillade, F Penault-Llorca, T Boulet, P Fouret, S Michiels, E Taranchon, G Mountzios, P Validire, J Domont, P Girard, et al. Immunohistochemichal expression of biomarkers: a comparative study between diagnostic bronchial biopsies and surgical specimens of non-small-cell lung cancer Ann. Onc., June 1, 2007; 18(6): 1043 - 1050. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Morgillo, W.-Y. Kim, E. S. Kim, F. Ciardiello, W. K. Hong, and H.-Y. Lee Implication of the Insulin-like Growth Factor-IR Pathway in the Resistance of Non small Cell Lung Cancer Cells to Treatment with Gefitinib Clin. Cancer Res., May 1, 2007; 13(9): 2795 - 2803. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Fujiwara, Y. Hosokawa, K. Watanabe, S. Tanimura, K.-i. Ozaki, and M. Kohno Blockade of the phosphatidylinositol-3-kinase-Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which the pathway is constitutively activated Mol. Cancer Ther., March 1, 2007; 6(3): 1133 - 1142. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Failly, S. Korur, V. Egler, J.-L. Boulay, M. M. Lino, R. Imber, and A. Merlo Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells Mol. Cancer Ther., February 1, 2007; 6(2): 773 - 781. [Abstract] [Full Text] [PDF] |
||||
![]() |
S.-H. Chang, K. N. Yu, Y.-S. Lee, G.-H. An, G. R. Beck Jr., N. H. Colburn, K.-H. Lee, and M.-H. Cho Elevated Inorganic Phosphate Stimulates Akt-ERK1/2-Mnk1 Signaling in Human Lung Cells Am. J. Respir. Cell Mol. Biol., November 1, 2006; 35(5): 528 - 539. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Liu, C. E. Denlinger, B. K. Rundall, P. W. Smith, and D. R. Jones Suberoylanilide Hydroxamic Acid Induces Akt-mediated Phosphorylation of p300, Which Promotes Acetylation and Transcriptional Activation of RelA/p65 J. Biol. Chem., October 20, 2006; 281(42): 31359 - 31368. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Morgillo, J. K. Woo, E. S. Kim, W. K. Hong, and H.-Y. Lee Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib. Cancer Res., October 15, 2006; 66(20): 10100 - 10111. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Hohla, A. V. Schally, K. Szepeshazi, J. L. Varga, S. Buchholz, F. Koster, E. Heinrich, G. Halmos, F. G. Rick, C. Kannadka, et al. Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel PNAS, September 26, 2006; 103(39): 14513 - 14518. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. El-Bayoumy, A. Das, B. Narayanan, N. Narayanan, E. S. Fiala, D. Desai, C. V. Rao, S. Amin, and R. Sinha Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer Carcinogenesis, July 1, 2006; 27(7): 1369 - 1376. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-H. Lee, S.-W. Han, P. G. Hwang, D.-Y. Oh, D.-W. Kim, D. H. Chung, S.-A. Im, T.-Y. Kim, D. S. Heo, and Y.-J. Bang Epidermal Growth Factor Receptor Mutations and Response to Chemotherapy in Patients with Non-Small-Cell Lung Cancer. Jpn. J. Clin. Oncol., June 1, 2006; 36(6): 344 - 350. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. A. Warfel, E. R. Lepper, C. Zhang, W. D. Figg, and P. A. Dennis Importance of the Stress Kinase p38{alpha} in Mediating the Direct Cytotoxic Effects of the Thalidomide Analogue, CPS49, in Cancer Cells and Endothelial Cells. Clin. Cancer Res., June 1, 2006; 12(11): 3502 - 3509. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Li, Y. Lu, W. Jin, K. Liang, G. B. Mills, and Z. Fan Autophosphorylation of Akt at Threonine 72 and Serine 246: A POTENTIAL MECHANISM OF REGULATION OF Akt KINASE ACTIVITY J. Biol. Chem., May 12, 2006; 281(19): 13837 - 13843. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Huh, A. Liepins, J. Zielonka, C. Andrekopoulos, B. Kalyanaraman, and A. Sorokin Cyclooxygenase 2 Rescues LNCaP Prostate Cancer Cells from Sanguinarine-Induced Apoptosis by a Mechanism Involving Inhibition of Nitric Oxide Synthase Activity. Cancer Res., April 1, 2006; 66(7): 3726 - 3736. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. Granville, R. M. Memmott, J. J. Gills, and P. A. Dennis Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway Clin. Cancer Res., February 1, 2006; 12(3): 679 - 689. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Tsurutani, J. Fukuoka, H. Tsurutani, J. H. Shih, S. M. Hewitt, W. D. Travis, J. Jen, and P. A. Dennis Evaluation of Two Phosphorylation Sites Improves the Prognostic Significance of Akt Activation in Non-Small-Cell Lung Cancer Tumors J. Clin. Oncol., January 10, 2006; 24(2): 306 - 314. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. M. Lee, C. B. Fuhrman, V. Planelles, M. R. Peltier, D. K. Gaffney, A. P. Soisson, M. K. Dodson, H. D. Tolley, C. L. Green, and K. A. Zempolich Phosphatidylinositol 3-Kinase Inhibition by LY294002 Radiosensitizes Human Cervical Cancer Cell Lines Clin. Cancer Res., January 1, 2006; 12(1): 250 - 256. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Dutu, S. Michiels, P. Fouret, F. Penault-Llorca, P. Validire, S. Benhamou, E. Taranchon, L. Morat, D. Grunenwald, T. Le Chevalier, et al. Differential expression of biomarkers in lung adenocarcinoma: a comparative study between smokers and never-smokers Ann. Onc., December 1, 2005; 16(12): 1906 - 1914. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-Y. Lee, S.-H. Oh, J. K. Woo, W.-Y. Kim, C. S. Van Pelt, R. E. Price, D. Cody, H. Tran, J. M. Pezzuto, R. M. Moriarty, et al. Chemopreventive Effects of Deguelin, a Novel Akt Inhibitor, on Tobacco-Induced Lung Tumorigenesis J Natl Cancer Inst, November 16, 2005; 97(22): 1695 - 1699. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. E. Denlinger, B. K. Rundall, and D. R. Jones Inhibition of phosphatidylinositol 3-kinase/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo J. Thorac. Cardiovasc. Surg., November 1, 2005; 130(5): 1422 - 1429. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Sithanandam, G. T. Smith, J. R. Fields, L. W. Fornwald, and L. M. Anderson Alternate Paths from Epidermal Growth Factor Receptor to Akt in Malignant Versus Nontransformed Lung Epithelial Cells: ErbB3 Versus Gab1 Am. J. Respir. Cell Mol. Biol., November 1, 2005; 33(5): 490 - 499. [Abstract] [Full Text] [PDF] |
||||
![]() |
J Lim, J-H Kim, J-Y Paeng, M-J Kim, S-D Hong, J-I Lee, and S-P Hong Prognostic value of activated Akt expression in oral squamous cell carcinoma J. Clin. Pathol., November 1, 2005; 58(11): 1199 - 1205. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-C. Chen, Y.-N. Su, P.-C. Chou, W.-C. Chiang, M.-C. Chang, L.-S. Wang, S.-C. Teng, and K.-J. Wu Overexpression of NBS1 Contributes to Transformation through the Activation of Phosphatidylinositol 3-Kinase/Akt J. Biol. Chem., September 16, 2005; 280(37): 32505 - 32511. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Tsurutani, K. A. West, J. Sayyah, J. J. Gills, and P. A. Dennis Inhibition of the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway but not the MEK/ERK Pathway Attenuates Laminin-Mediated Small Cell Lung Cancer Cellular Survival and Resistance to Imatinib Mesylate or Chemotherapy Cancer Res., September 15, 2005; 65(18): 8423 - 8432. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Oka, S. Nakahara, Y. Takenaka, T. Fukumori, V. Hogan, H.-o. Kanayama, T. Yanagawa, and A. Raz Galectin-3 Inhibits Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Activating Akt in Human Bladder Carcinoma Cells Cancer Res., September 1, 2005; 65(17): 7546 - 7553. [Abstract] [Full Text] [PDF] |
||||
![]() |
I.-A. Kim, S.-S. Bae, A. Fernandes, J. Wu, R. J. Muschel, W. G. McKenna, M. J. Birnbaum, and E. J. Bernhard Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines Cancer Res., September 1, 2005; 65(17): 7902 - 7910. [Abstract] [Full Text] [PDF] |
||||
![]() |
L.-Z. Liu, J. Fang, Q. Zhou, X. Hu, X. Shi, and B.-H. Jiang Apigenin Inhibits Expression of Vascular Endothelial Growth Factor and Angiogenesis in Human Lung Cancer Cells: Implication of Chemoprevention of Lung Cancer Mol. Pharmacol., September 1, 2005; 68(3): 635 - 643. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Guo, M. Chu, T. Abbeyquaye, and C.-Y. Chen Persistent Nicotine Treatment Potentiates Amplification of the Dihydrofolate Reductase Gene in Rat Lung Epithelial Cells as a Consequence of Ras Activation J. Biol. Chem., August 26, 2005; 280(34): 30422 - 30431. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-Y. Lee, S.-H. Oh, Y.-A. Suh, J. H. Baek, V. Papadimitrakopoulou, S. Huang, and W. K. Hong Response of Non-Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH2-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer Clin. Cancer Res., August 15, 2005; 11(16): 6065 - 6074. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. A. Rascoe, X. Cao, J. C. Daniel, S. D. Miller, and W. R. Smythe Receptor tyrosine kinase and phosphoinositide-3 kinase signaling in malignant mesothelioma J. Thorac. Cardiovasc. Surg., August 1, 2005; 130(2): 393 - 400. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. M. Bruzek, J. N. Poynter, S. H. Kaufmann, and A. A. Adjei Characterization of a Human Carcinoma Cell Line Selected for Resistance to the Farnesyl Transferase Inhibitor 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH66336) Mol. Pharmacol., August 1, 2005; 68(2): 477 - 486. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Zheng, G. Bepler, A. Cantor, and E. B. Haura Small Tumor Size and Limited Smoking History Predicts Activated Epidermal Growth Factor Receptor in Early-Stage Non-small Cell Lung Cancer Chest, July 1, 2005; 128(1): 308 - 316. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Cortes-Funes, C. Gomez, R. Rosell, P. Valero, C. Garcia-Giron, A. Velasco, A. Izquierdo, P. Diz, C. Camps, D. Castellanos, et al. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients Ann. Onc., July 1, 2005; 16(7): 1081 - 1086. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Tsurutani, S.S. Castillo, J. Brognard, C. A. Granville, C. Zhang, J. J. Gills, J. Sayyah, and P. A. Dennis Tobacco components stimulate Akt-dependent proliferation and NF{kappa}B-dependent survival in lung cancer cells Carcinogenesis, July 1, 2005; 26(7): 1182 - 1195. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. J. Phillips, J. Mestas, M. Gharaee-Kermani, M. D. Burdick, A. Sica, J. A. Belperio, M. P. Keane, and R. M. Strieter Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1{alpha} J. Biol. Chem., June 10, 2005; 280(23): 22473 - 22481. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Hurbin, J.-L. Coll, L. Dubrez-Daloz, B. Mari, P. Auberger, C. Brambilla, and M.-C. Favrot Cooperation of Amphiregulin and Insulin-like Growth Factor-1 Inhibits Bax- and Bad-mediated Apoptosis via a Protein Kinase C-dependent Pathway in Non-small Cell Lung Cancer Cells J. Biol. Chem., May 20, 2005; 280(20): 19757 - 19767. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Wislez, M. L. Spencer, J. G. Izzo, D. M. Juroske, K. Balhara, D. D. Cody, R. E. Price, W. N. Hittelman, I. I. Wistuba, and J. M. Kurie Inhibition of Mammalian Target of Rapamycin Reverses Alveolar Epithelial Neoplasia Induced by Oncogenic K-ras Cancer Res., April 15, 2005; 65(8): 3226 - 3235. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Shah, W. A. Swain, D. Richardson, J. Edwards, D. J. Stewart, C. M. Richardson, D. E.B. Swinson, D. Patel, J. L. Jones, and K. J. O'Byrne Phospho-Akt Expression Is Associated with a Favorable Outcome in Non-Small Cell Lung Cancer Clin. Cancer Res., April 15, 2005; 11(8): 2930 - 2936. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Ferraro, G. Bepler, S. Sharma, A. Cantor, and E. B. Haura EGR1 Predicts PTEN and Survival in Patients With Non-Small-Cell Lung Cancer J. Clin. Oncol., March 20, 2005; 23(9): 1921 - 1926. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Li, J. Jaboin, P. A. Dennis, and C. J. Thiele Genetic and Pharmacologic Identification of Akt as a Mediator of Brain-Derived Neurotrophic Factor/TrkB Rescue of Neuroblastoma Cells from Chemotherapy-Induced Cell Death Cancer Res., March 15, 2005; 65(6): 2070 - 2075. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. S. Fiala, O. S. Sohn, C.-X. Wang, E. Seibert, J. Tsurutani, P. A. Dennis, K. El-Bayoumy, R. S. Sodum, D. Desai, J. Reinhardt, et al. Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E Carcinogenesis, March 1, 2005; 26(3): 605 - 612. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Chu, J. Guo, and C.-Y. Chen Long-term Exposure to Nicotine, via Ras Pathway, Induces Cyclin D1 to Stimulate G1 Cell Cycle Transition J. Biol. Chem., February 25, 2005; 280(8): 6369 - 6379. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. G. Viniegra, N. Martinez, P. Modirassari, J. H. Losa, C. P. Cobo, V. J. S.-A. Lobo, C. I. A. Luquero, L. Alvarez-Vallina, S. Ramon y Cajal, J. M. Rojas, et al. Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM J. Biol. Chem., February 11, 2005; 280(6): 4029 - 4036. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. V. Thomas, S. Horvath, B. L. Smith, K. Crosby, L. A. Lebel, M. Schrage, J. Said, J. De Kernion, R. E. Reiter, and C. L. Sawyers Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer Clin. Cancer Res., December 15, 2004; 10(24): 8351 - 8356. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-M. Peng, S.-M. Liang, and C.-M. Liang VP1 of Foot-and-Mouth Disease Virus Induces Apoptosis via the Akt Signaling Pathway J. Biol. Chem., December 10, 2004; 279(50): 52168 - 52174. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. L. Chen, P. Y. Law, and H. H. Loh Inhibition of Akt/Protein Kinase B Signaling by Naltrindole in Small Cell Lung Cancer Cells Cancer Res., December 1, 2004; 64(23): 8723 - 8730. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. VanderWeele, R. Zhou, and C. M. Rudin Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin Mol. Cancer Ther., December 1, 2004; 3(12): 1605 - 1613. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. W. Kim, I. K. Park, C. S. Cho, K. H. Lee, G. R. Beck Jr., N. H. Colburn, and M. H. Cho Aerosol Delivery of Glucosylated Polyethylenimine/Phosphatase and Tensin Homologue Deleted on Chromosome 10 Complex Suppresses Akt Downstream Pathways in the Lung of K-ras Null Mice Cancer Res., November 1, 2004; 64(21): 7971 - 7976. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. R. Balsara, J. Pei, Y. Mitsuuchi, R. Page, A. Klein-Szanto, H. Wang, M. Unger, and J. R. Testa Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions Carcinogenesis, November 1, 2004; 25(11): 2053 - 2059. [Abstract] [Full Text] [PDF] |
||||
![]() |
H.-Y. Lee, H. Moon, K.-H. Chun, Y.-S. Chang, K. Hassan, L. Ji, R. Lotan, F. R. Khuri, and W. K. Hong Effects of Insulin-like Growth Factor Binding Protein-3 and Farnesyltransferase Inhibitor SCH66336 on Akt Expression and Apoptosis in Non-Small-Cell Lung Cancer Cells J Natl Cancer Inst, October 20, 2004; 96(20): 1536 - 1548. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tracy, T. Mukohara, M. Hansen, M. Meyerson, B. E. Johnson, and P. A. Janne Gefitinib Induces Apoptosis in the EGFRL858R Non-Small-Cell Lung Cancer Cell Line H3255 Cancer Res., October 15, 2004; 64(20): 7241 - 7244. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. David, J. Jett, H. LeBeau, G. Dy, J. Hughes, M. Friedman, and A. R. Brody Phospho-Akt Overexpression in Non-Small Cell Lung Cancer Confers Significant Stage-Independent Survival Disadvantage Clin. Cancer Res., October 15, 2004; 10(20): 6865 - 6871. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. deGraffenried, L. Fulcher, W. E. Friedrichs, V. Grunwald, R. B. Ray, and M. Hidalgo Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway Ann. Onc., October 1, 2004; 15(10): 1510 - 1516. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Tell, A. Pines, F. Arturi, L. Cesaratto, E. Adamson, C. Puppin, I. Presta, D. Russo, S. Filetti, and G. Damante Control of Phosphatase and Tensin Homolog (PTEN) Gene Expression in Normal and Neoplastic Thyroid Cells Endocrinology, October 1, 2004; 145(10): 4660 - 4666. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Pold, K. Krysan, A. Pold, M. Dohadwala, N. Heuze-Vourc'h, J. T. Mao, K. L. Riedl, S. Sharma, and S. M. Dubinett Cyclooxygenase-2 Modulates the Insulin-Like Growth Factor Axis in Non-Small-Cell Lung Cancer Cancer Res., September 15, 2004; 64(18): 6549 - 6555. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Cappuzzo, E. Magrini, G. L. Ceresoli, S. Bartolini, E. Rossi, V. Ludovini, V. Gregorc, C. Ligorio, A. Cancellieri, S. Damiani, et al. Akt Phosphorylation and Gefitinib Efficacy in Patients With Advanced Non-Small-Cell Lung Cancer J Natl Cancer Inst, August 4, 2004; 96(15): 1133 - 1141. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. Bartling, J.-Y. Yang, D. Michod, C. Widmann, R. Lewensohn, and B. Zhivotovsky RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide Carcinogenesis, June 1, 2004; 25(6): 909 - 921. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tanno, N. Yanagawa, A. Habiro, K. Koizumi, Y. Nakano, M. Osanai, Y. Mizukami, T. Okumura, J. R. Testa, and Y. Kohgo Serine/Threonine Kinase AKT Is Frequently Activated in Human Bile Duct Cancer and Is Associated with Increased Radioresistance Cancer Res., May 15, 2004; 64(10): 3486 - 3490. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Kurie Role of Protein Kinase B-Dependent Signaling in Lung Tumorigenesis Chest, May 1, 2004; 125(5_suppl): 141S - 144S. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. S. Castillo, J. Brognard, P. A. Petukhov, C. Zhang, J. Tsurutani, C. A. Granville, M. Li, M. Jung, K. A. West, J. G. Gills, et al. Preferential Inhibition of Akt and Killing of Akt-Dependent Cancer Cells by Rationally Designed Phosphatidylinositol Ether Lipid Analogues Cancer Res., April 15, 2004; 64(8): 2782 - 2792. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. K. Park, Y. M. Chung, B.-G. Kim, Y.-A Yoo, B.-S. Yang, J. S. Kim, and Y. D. Yoo N'-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells Mol. Cancer Ther., April 1, 2004; 3(4): 403 - 407. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Dowlati, D. Nethery, and J. A. Kern Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy Mol. Cancer Ther., April 1, 2004; 3(4): 459 - 463. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. M. Vasudevan, S. Gurumurthy, and V. M. Rangnekar Suppression of PTEN Expression by NF-{kappa}B Prevents Apoptosis Mol. Cell. Biol., February 1, 2004; 24(3): 1007 - 1021. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. M. Nguyen, G. A. Chen, R. Reddy, W. Tsai, W. D. Schrump, G. Cole Jr, and D. S. Schrump Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway J. Thorac. Cardiovasc. Surg., February 1, 2004; 127(2): 365 - 375. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. A. West, I. R. Linnoila, S. A. Belinsky, C. C. Harris, and P. A. Dennis Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3'-Kinase/Akt Pathway in Vitro and in Vivo Cancer Res., January 15, 2004; 64(2): 446 - 451. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Sumitomo, T. Asano, J. Asakuma, T. Asano, A. Horiguchi, and M. Hayakawa ZD1839 Modulates Paclitaxel Response in Renal Cancer by Blocking Paclitaxel-Induced Activation of the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase Pathway Clin. Cancer Res., January 15, 2004; 10(2): 794 - 801. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Okudela, H. Hayashi, T. Ito, T. Yazawa, T. Suzuki, Y. Nakane, H. Sato, H. Ishi, X. KeQin, A. Masuda, et al. K-ras Gene Mutation Enhances Motility of Immortalized Airway Cells and Lung Adenocarcinoma Cells via Akt Activation: Possible Contribution to Non-Invasive Expansion of Lung Adenocarcinoma Am. J. Pathol., January 1, 2004; 164(1): 91 - 100. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Holleman, M. L. d. Boer, K. M. Kazemier, G. E. Janka-Schaub, and R. Pieters Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia Blood, December 15, 2003; 102(13): 4541 - 4546. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Jetzt, J. A. Howe, M. T. Horn, E. Maxwell, Z. Yin, D. Johnson, and C. C. Kumar Adenoviral-Mediated Expression of a Kinase-Dead Mutant of Akt Induces Apoptosis Selectively in Tumor Cells and Suppresses Tumor Growth in Mice Cancer Res., October 15, 2003; 63(20): 6697 - 6706. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Sithanandam, G. T. Smith, A. Masuda, T. Takahashi, L. M. Anderson, and L. W. Fornwald Cell cycle activation in lung adenocarcinoma cells by the ErbB3/phosphatidylinositol 3-kinase/Akt pathway Carcinogenesis, October 1, 2003; 24(10): 1581 - 1592. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. B.Y. Ma, R. G. Bristow, J. Kim, and L. L. Siu Combined-Modality Treatment of Solid Tumors Using Radiotherapy and Molecular Targeted Agents J. Clin. Oncol., July 15, 2003; 21(14): 2760 - 2776. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |