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[Cancer Research 61, 4341-4344, June 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Kinetics and Viability of Circulating Endothelial Cells As Surrogate Angiogenesis Marker in an Animal Model of Human Lymphoma1

Silvia Monestiroli, Patrizia Mancuso, Alessandra Burlini, Giancarlo Pruneri, Chiara Dell’Agnola, Alberto Gobbi, Giovanni Martinelli and Francesco Bertolini2

Divisions of Hematology-Oncology [P. M., A. B., C. D., G. M., F. B.], Experimental Oncology [S. M., A. G.], and Pathology [G. P.], European Institute of Oncology, 20141 Milan, Italy

Circulating endothelial cells (CECs) were evaluated by flow cytometry in immunodeficient mice bearing human lymphoma. A trend toward higher CEC values was observed on days 7 and 14 after transplant, and differences versus controls were highly significant on day 21 (P = 0.0061). A strong correlation was found between CEC and tumor volume (r, 0.942; P = 0.004) and between CEC and tumor-generated VEGF (r, 0.669; P = 0.02). In mice given cyclophosphamide, most of the circulating apoptotic cells were hematopoietic and not endothelial. Conversely, in mice given endostatin, all of the increase in apoptotic cells was in the endothelial cell compartment. CEC evaluation is promising as a noninvasive, surrogate angiogenesis marker.




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Cancer Research Clinical Cancer Research
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Copyright © 2001 by the American Association for Cancer Research.