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[Cancer Research 61, 4671-4674, June 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

NY-ESO-1 Expression and Immunogenicity Associated with Transitional Cell Carcinoma

Correlation with Tumor Grade1

Takushi Kurashige, Yuji Noguchi2, Takashi Saika, Toshiro Ono, Yasuhiro Nagata, Achim Jungbluth, Gerd Ritter, Yao-Tseng Chen, Elisabeth Stockert, Tomoyasu Tsushima, Hiromi Kumon, Lloyd J. Old and Eiichi Nakayama

Departments of Urology [T. K., T. S., T. T., H. K.] and Immunology [Y. No., T. O., E. N.], Okayama University Medical School, Okayama 700-8558, Japan; Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York, New York 10021 [Y. Na., A. J., G. R., Y-T. C., E. S., L. J. O.]; and Department of Pathology, Cornell University Medical College, New York, New York 10021 [Y-T. C.]

NY-ESO-1 mRNA expression in transitional cell carcinoma was investigated by reverse transcription-PCR and immunohistochemistry. NY-ESO-1 mRNA was detected in 20 of 62 (32%) tumor specimens. There was a correlation between NY-ESO-1 expression and tumor grade: 0 of 4 (0%) grade 1 (G1), 6 of 26 (23%) grade 2 (G2), and 14 of 32 (44%) grade 3 (G3) tumors were NY-ESO-1 mRNA positive. Immunohistochemical analysis using NY-ESO-1-specific monoclonal antibody ES121 showed that 2 of 14 NY-ESO-1 mRNA-expressing G3 tumors were positive for NY-ESO-1. No NY-ESO-1 staining was observed in the panel of 30 G1 or G2 tumor specimens, including 6 NY-ESO-1 mRNA-positive cases. Sera from an expanded panel of 124 patients with transitional cell carcinoma were tested for the presence of NY-ESO-1 antibody. Seropositivity was observed in 9 of 72 (12.5%) patients with G3 tumors, whereas none of 52 patients with G1 or G2 tumors produced antibody against NY-ESO-1. In the 9 positive patients with NY-ESO-1 antibody, 4 had muscular invasive tumors, and 5 had carcinoma in situ.




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