Cancer Research Meeting Calendar Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Glinsky, V. V.
Right arrow Articles by Quinn, T. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glinsky, V. V.
Right arrow Articles by Quinn, T. P.
[Cancer Research 61, 4851-4857, June 15, 2001]
© 2001 American Association for Cancer Research

Tumor Biology

The Role of Thomsen-Friedenreich Antigen in Adhesion of Human Breast and Prostate Cancer Cells to the Endothelium1

Vladislav V. Glinsky, Gennadi V. Glinsky, Kate Rittenhouse-Olson, Margaret E. Huflejt, Olga V. Glinskii, Susan L. Deutscher and Thomas P. Quinn2

Department of Biochemistry, University of Missouri, Columbia, Missouri 65211 [V. V. G., O. V. G., S. L. D., T. P. Q.]; Cancer Research Center, Columbia, Missouri 65201 [V. V. G.]; Sidney Kimmel Cancer Center, San Diego, California 92121 [G. V. G., M. E. H.]; Metastat, Inc., San Diego, California 92121 [G. V. G.]; and Department of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, New York 14214 [K. R-O.]

Interactions of metastatic cancer cells with vasculatory endothelium are critical during early stages of cancer metastasis. Understanding the molecular underpinnings of these interactions is essential for the development of new efficacious cancer therapies. Here we demonstrate that cancer-associated carbohydrate T antigen plays a leading role in docking breast and prostate cancer cells onto endothelium by specifically interacting with endothelium-expressed ß-galactoside-binding protein, galectin-3. Importantly, T antigen-bearing glycoproteins are also capable of mobilizing galectin-3 to the surface of endothelial cells, thus priming them for harboring metastatic cancer cells. The T antigen-mediated, tumor-endothelial cell interactions could be efficiently disrupted using synthetic compounds either mimicking or masking this carbohydrate structure. High efficiency of T antigen-mimicking and T antigen-masking inhibitors of tumor cell adhesion warrants their further development into antiadhesive cancer therapeutics.




This article has been cited by other articles:


Home page
 GlycobiologyHome page
C. Danussi, A. Coslovi, C. Campa, M. T Mucignat, P. Spessotto, F. Uggeri, S. Paoletti, and A. Colombatti
A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction
Glycobiology, October 1, 2009; 19(10): 1056 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Zhao, X. Guo, G. B. Nash, P. C. Stone, J. Hilkens, J. M. Rhodes, and L.-G. Yu
Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface
Cancer Res., September 1, 2009; 69(17): 6799 - 6806.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Argueso, A. Guzman-Aranguez, F. Mantelli, Z. Cao, J. Ricciuto, and N. Panjwani
Association of Cell Surface Mucins with Galectin-3 Contributes to the Ocular Surface Epithelial Barrier
J. Biol. Chem., August 21, 2009; 284(34): 23037 - 23045.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Lu, Q. Wang, G. Hu, C. Van Poznak, M. Fleisher, M. Reiss, J. Massague, and Y. Kang
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis
Genes & Dev., August 15, 2009; 23(16): 1882 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. V Norling, M. Perretti, and D. Cooper
Endogenous galectins and the control of the host inflammatory response
J. Endocrinol., May 1, 2009; 201(2): 169 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. Nowak, J. Madej, P. Dziegiel, W. Lopuszynski, A. Rodo, and M. Ugorski
Tumor-associated Carbohydrate Antigens: Sialyl Lea and T/Tn Antigens in Canine Mammary Tumors
Vet. Pathol., March 1, 2009; 46(2): 222 - 226.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
S. R. Kumar and S. L. Deutscher
111In-Labeled Galectin-3-Targeting Peptide as a SPECT Agent for Imaging Breast Tumors
J. Nucl. Med., May 1, 2008; 49(5): 796 - 803.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. R. Stowell, C. M. Arthur, P. Mehta, K. A. Slanina, O. Blixt, H. Leffler, D. F. Smith, and R. D. Cummings
Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens
J. Biol. Chem., April 11, 2008; 283(15): 10109 - 10123.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
F. H.M. de Melo, D. Butera, R. S. Medeiros, L. N. d. S. Andrade, S. Nonogaki, F. A. Soares, R. A. Alvarez, A. M. Moura da Silva, and R. Chammas
Biological Applications of a Chimeric Probe for the Assessment of Galectin-3 Ligands
J. Histochem. Cytochem., October 1, 2007; 55(10): 1015 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. J. Sabbatini, G. Ragupathi, C. Hood, C. A. Aghajanian, M. Juretzka, A. Iasonos, M. L. Hensley, M. K. Spassova, O. Ouerfelli, D. R. Spriggs, et al.
Pilot Study of a Heptavalent Vaccine-Keyhole Limpet Hemocyanin Conjugate plus QS21 in Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
Clin. Cancer Res., July 15, 2007; 13(14): 4170 - 4177.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. F. Valenzuela, K. E. Pace, P. V. Cabrera, R. White, K. Porvari, H. Kaija, P. Vihko, and L. G. Baum
O-Glycosylation Regulates LNCaP Prostate Cancer Cell Susceptibility to Apoptosis Induced by Galectin-1
Cancer Res., July 1, 2007; 67(13): 6155 - 6162.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-G. Yu, N. Andrews, Q. Zhao, D. McKean, J. F. Williams, L. J. Connor, O. V. Gerasimenko, J. Hilkens, J. Hirabayashi, K. Kasai, et al.
Galectin-3 Interaction with Thomsen-Friedenreich Disaccharide on Cancer-associated MUC1 Causes Increased Cancer Cell Endothelial Adhesion
J. Biol. Chem., January 5, 2007; 282(1): 773 - 781.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. R. Kumar, E. R. Sauter, T. P. Quinn, and S. L. Deutscher
Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection
Clin. Cancer Res., October 1, 2005; 11(19): 6868 - 6871.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
O. Berezovskaya, A. D. Schimmer, A. B. Glinskii, C. Pinilla, R. M. Hoffman, J. C. Reed, and G. V. Glinsky
Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells
Cancer Res., March 15, 2005; 65(6): 2378 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
J. Zou, V. V. Glinsky, L. A. Landon, L. Matthews, and S. L. Deutscher
Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion
Carcinogenesis, February 1, 2005; 26(2): 309 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. J. Dimitroff, M. Lechpammer, D. Long-Woodward, and J. L. Kutok
Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin
Cancer Res., August 1, 2004; 64(15): 5261 - 5269.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J.-i. Fukushi, I. T. Makagiansar, and W. B. Stallcup
NG2 Proteoglycan Promotes Endothelial Cell Motility and Angiogenesis via Engagement of Galectin-3 and {alpha}3{beta}1 Integrin
Mol. Biol. Cell, August 1, 2004; 15(8): 3580 - 3590.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. I. Romanov, T. Whyard, H. L. Adler, W. C. Waltzer, and S. Zucker
Prostate Cancer Cell Adhesion to Bone Marrow Endothelium: The Role of Prostate-Specific Antigen
Cancer Res., March 15, 2004; 64(6): 2083 - 2089.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
O. V. Glinskii, J. R. Turk, K. J. Pienta, V. H. Huxley, and V. V. Glinsky
Evidence of porcine and human endothelium activation by cancer-associated carbohydrates expressed on glycoproteins and tumour cells
J. Physiol., January 1, 2004; 554(1): 89 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. V. Glinsky, G. V. Glinsky, O. V. Glinskii, V. H. Huxley, J. R. Turk, V. V. Mossine, S. L. Deutscher, K. J. Pienta, and T. P. Quinn
Intravascular Metastatic Cancer Cell Homotypic Aggregation at the Sites of Primary Attachment to the Endothelium
Cancer Res., July 1, 2003; 63(13): 3805 - 3811.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. M. John, H. Leffler, B. Kahl-Knutsson, I. Svensson, and G. A. Jarvis
Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer
Clin. Cancer Res., June 1, 2003; 9(6): 2374 - 2383.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Mareel and A. Leroy
Clinical, Cellular, and Molecular Aspects of Cancer Invasion
Physiol Rev, April 1, 2003; 83(2): 337 - 376.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. K. Khaldoyanidi, V. V. Glinsky, L. Sikora, A. B. Glinskii, V. V. Mossine, T. P. Quinn, G. V. Glinsky, and P. Sriramarao
MDA-MB-435 Human Breast Carcinoma Cell Homo- and Heterotypic Adhesion under Flow Conditions Is Mediated in Part by Thomsen-Friedenreich Antigen-Galectin-3 Interactions
J. Biol. Chem., January 31, 2003; 278(6): 4127 - 4134.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kudo, T. Iwai, T. Kubota, H. Iwasaki, Y. Takayma, T. Hiruma, N. Inaba, Y. Zhang, M. Gotoh, A. Togayachi, et al.
Molecular Cloning and Characterization of a Novel UDP-Gal:GalNAcalpha Peptide beta 1,3-Galactosyltransferase (C1Gal-T2), an Enzyme Synthesizing a Core 1 Structure of O-Glycan
J. Biol. Chem., November 27, 2002; 277(49): 47724 - 47731.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.