This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scotton, C. J. Articles by Balkwill, F. R. Search for Related Content PubMed PubMed Citation Articles by Scotton, C. J. Articles by Balkwill, F. R.

Epithelial Cancer Cell Migration

A Role for Chemokine Receptors?

Imperial Cancer Research Fund Translational Oncology Laboratory, Barts and the Royal London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom [C. J. S., J. L. W., D. M., F. R. B.], and Department of Histopathology, Division of Investigative Sciences, Imperial College School of Medicine, Hammersmith Hospital Campus, London W12 ONN, United Kingdom [G. S.]

We investigated the possibility that chemokine gradients influence migration of human ovarian epithelial tumor cells. Of 14 chemokine receptors investigated, only CXCR4 was expressed on ovarian cancer cells. CXCR4 mRNA localized to a subpopulation of tumor cells in ovarian cancer biopsies. Ovarian cancer cell lines and cells freshly isolated from ascites expressed CXCR4 protein. The CXCR4 ligand, CXCL12, was found in ascites from 63 patients. CXCL12 elicited intracellular calcium flux and directed migration and changes in integrin expression in ovarian cancer cells. CXCR4 may influence cell migration in the peritoneum, a major route for ovarian cancer spread, and could be a therapeutic target.

This article has been cited by other articles:

				D. Wong and W. Korz Translating an Antagonist of Chemokine Receptor CXCR4: From Bench to Bedside Clin. Cancer Res., December 15, 2008; 14(24): 7975 - 7980. [Abstract] [Full Text] [PDF]

				R M Thomas, J Kim, M P Revelo-Penafiel, R Angel, D W Dawson, and A M Lowy The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia Gut, November 1, 2008; 57(11): 1555 - 1560. [Abstract] [Full Text] [PDF]

				B. E. Bachmeier, I. V. Mohrenz, V. Mirisola, E. Schleicher, F. Romeo, C. Hohneke, M. Jochum, A. G. Nerlich, and U. Pfeffer Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NF{kappa}B Carcinogenesis, April 1, 2008; 29(4): 779 - 789. [Abstract] [Full Text] [PDF]

				F. F. Amersi, A. M. Terando, Y. Goto, R. A. Scolyer, J. F. Thompson, A. N. Tran, M. B. Faries, D. L. Morton, and D. S.B. Hoon Activation of CCR9/CCL25 in Cutaneous Melanoma Mediates Preferential Metastasis to the Small Intestine Clin. Cancer Res., February 1, 2008; 14(3): 638 - 645. [Abstract] [Full Text] [PDF]

				B.-R. Lin, C.-C. Chang, L.-R. Chen, M.-H. Wu, M.-Y. Wang, I-H. Kuo, C.-Y. Chu, K.-J. Chang, P.-H. Lee, W.-J. Chen, et al. Cysteine-Rich 61 (CCN1) Enhances Chemotactic Migration, Transendothelial Cell Migration, and Intravasation by Concomitantly Up-Regulating Chemokine Receptor 1 and 2 Mol. Cancer Res., November 1, 2007; 5(11): 1111 - 1123. [Abstract] [Full Text] [PDF]

				X. Wang, H. Yuling, J. Yanping, T. Xinti, Y. Yaofang, Y. Feng, X. Ruijin, W. Li, C. Lang, L. Jingyi, et al. CCL19 and CXCL13 Synergistically Regulate Interaction between B Cell Acute Lymphocytic Leukemia CD23+CD5+ B Cells and CD8+ T Cells J. Immunol., September 1, 2007; 179(5): 2880 - 2888. [Abstract] [Full Text] [PDF]

				J. M. Cerutti, G. Oler, P. Michaluart Jr., R. Delcelo, R. M. Beaty, J. Shoemaker, and G. J. Riggins Molecular Profiling of Matched Samples Identifies Biomarkers of Papillary Thyroid Carcinoma Lymph Node Metastasis Cancer Res., August 15, 2007; 67(16): 7885 - 7892. [Abstract] [Full Text] [PDF]

				M. Satpathy, L. Cao, R. Pincheira, R. Emerson, R. Bigsby, H. Nakshatri, and D. Matei Enhanced Peritoneal Ovarian Tumor Dissemination by Tissue Transglutaminase Cancer Res., August 1, 2007; 67(15): 7194 - 7202. [Abstract] [Full Text] [PDF]

				E. L. Hsu, D. Yoon, H. H. Choi, F. Wang, R. T. Taylor, N. Chen, R. Zhang, and O. Hankinson A Proposed Mechanism for the Protective Effect of Dioxin against Breast Cancer Toxicol. Sci., August 1, 2007; 98(2): 436 - 444. [Abstract] [Full Text] [PDF]

				D. Uchida, T. Onoue, Y. Tomizuka, N. M. Begum, Y. Miwa, H. Yoshida, and M. Sato Involvement of an Autocrine Stromal Cell Derived Factor-1/CXCR4 System on the Distant Metastasis of Human Oral Squamous Cell Carcinoma Mol. Cancer Res., July 1, 2007; 5(7): 685 - 694. [Abstract] [Full Text] [PDF]

				I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis Am J Physiol Cell Physiol, March 1, 2007; 292(3): C987 - C995. [Abstract] [Full Text] [PDF]

				H. Chunsong, H. Yuling, W. Li, X. Jie, Z. Gang, Z. Qiuping, G. Qingping, Z. Kejian, Q. Li, A. E. Chang, et al. CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells J. Immunol., November 15, 2006; 177(10): 6713 - 6722. [Abstract] [Full Text] [PDF]

				J. Meijer, I. S. Zeelenberg, B. Sipos, and E. Roos The CXCR5 Chemokine Receptor Is Expressed by Carcinoma Cells and Promotes Growth of Colon Carcinoma in the Liver Cancer Res., October 1, 2006; 66(19): 9576 - 9582. [Abstract] [Full Text] [PDF]

				T. C. Walser, S. Rifat, X. Ma, N. Kundu, C. Ward, O. Goloubeva, M. G. Johnson, J. C. Medina, T. L. Collins, and A. M. Fulton Antagonism of CXCR3 Inhibits Lung Metastasis in a Murine Model of Metastatic Breast Cancer. Cancer Res., August 1, 2006; 66(15): 7701 - 7707. [Abstract] [Full Text] [PDF]

				T. Kakinuma and S. T. Hwang Chemokines, chemokine receptors, and cancer metastasis J. Leukoc. Biol., April 1, 2006; 79(4): 639 - 651. [Abstract] [Full Text] [PDF]

				S. Ohira, M. Sasaki, K. Harada, Y. Sato, Y. Zen, K. Isse, K. Kozaka, A. Ishikawa, K. Oda, Y. Nimura, et al. Possible Regulation of Migration of Intrahepatic Cholangiocarcinoma Cells by Interaction of CXCR4 Expressed in Carcinoma Cells with Tumor Necrosis Factor-{alpha} and Stromal-Derived Factor-1 Released in Stroma Am. J. Pathol., April 1, 2006; 168(4): 1155 - 1168. [Abstract] [Full Text] [PDF]

				H. Lu, W. Ouyang, and C. Huang Inflammation, a Key Event in Cancer Development Mol. Cancer Res., April 1, 2006; 4(4): 221 - 233. [Abstract] [Full Text] [PDF]

				L. Su, J. Zhang, H. Xu, Y. Wang, Y. Chu, R. Liu, and S. Xiong Differential Expression of CXCR4 Is Associated with the Metastatic Potential of Human Non-Small Cell Lung Cancer Cells Clin. Cancer Res., December 1, 2005; 11(23): 8273 - 8280. [Abstract] [Full Text] [PDF]

				H. Kulbe, T. Hagemann, P. W. Szlosarek, F. R. Balkwill, and J. L. Wilson The Inflammatory Cytokine Tumor Necrosis Factor-{alpha} Regulates Chemokine Receptor Expression on Ovarian Cancer Cells Cancer Res., November 15, 2005; 65(22): 10355 - 10362. [Abstract] [Full Text] [PDF]

				E. Schutyser, A. Richmond, and J. Van Damme Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes J. Leukoc. Biol., July 1, 2005; 78(1): 14 - 26. [Abstract] [Full Text] [PDF]

				R. J. Phillips, J. Mestas, M. Gharaee-Kermani, M. D. Burdick, A. Sica, J. A. Belperio, M. P. Keane, and R. M. Strieter Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1{alpha} J. Biol. Chem., June 10, 2005; 280(23): 22473 - 22481. [Abstract] [Full Text] [PDF]

				B.-C. Lee, T.-H. Lee, R. Zagozdzon, S. Avraham, A. Usheva, and H. K. Avraham Carboxyl-Terminal Src Kinase Homologous Kinase Negatively Regulates the Chemokine Receptor CXCR4 through YY1 and Impairs CXCR4/CXCL12 (SDF-1{alpha})-Mediated Breast Cancer Cell Migration Cancer Res., April 1, 2005; 65(7): 2840 - 2845. [Abstract] [Full Text] [PDF]

				J. M. Smith, P. A. Johanesen, M. K. Wendt, D. G. Binion, and M. B. Dwinell CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G316 - G326. [Abstract] [Full Text] [PDF]

				I. Kryczek, A. Lange, P. Mottram, X. Alvarez, P. Cheng, M. Hogan, L. Moons, S. Wei, L. Zou, V. Machelon, et al. CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers Cancer Res., January 15, 2005; 65(2): 465 - 472. [Abstract] [Full Text] [PDF]

				G. G. Vaday, S.-B. Hua, D. M. Peehl, M. H. Pauling, Y.-H. Lin, L. Zhu, D. M. Lawrence, H. D. Foda, and S. Zucker CXCR4 and CXCL12 (SDF-1) in Prostate Cancer: Inhibitory Effects of Human Single Chain Fv Antibodies Clin. Cancer Res., August 15, 2004; 10(16): 5630 - 5639. [Abstract] [Full Text] [PDF]

				Z. Liang, T. Wu, H. Lou, X. Yu, R. S. Taichman, S. K. Lau, S. Nie, J. Umbreit, and H. Shim Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4 Cancer Res., June 15, 2004; 64(12): 4302 - 4308. [Abstract] [Full Text] [PDF]

				K. Kawada, M. Sonoshita, H. Sakashita, A. Takabayashi, Y. Yamaoka, T. Manabe, K. Inaba, N. Minato, M. Oshima, and M. M. Taketo Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes Cancer Res., June 1, 2004; 64(11): 4010 - 4017. [Abstract] [Full Text] [PDF]

				M. B. Dwinell, H. Ogawa, K. E. Barrett, and M. F. Kagnoff SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G844 - G850. [Abstract] [Full Text] [PDF]

				N. E. Annels, A. J. Willemze, V. H. J. van der Velden, C. M. J. M. Faaij, E. van Wering, D. M. D. S. Sie-Go, R. M. Egeler, M. J. D. van Tol, and T. Revesz Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL Blood, April 1, 2004; 103(7): 2806 - 2808. [Abstract] [Full Text] [PDF]

				A. Corcione, N. Arduino, E. Ferretti, L. Raffaghello, S. Roncella, D. Rossi, F. Fedeli, L. Ottonello, L. Trentin, F. Dallegri, et al. CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells Clin. Cancer Res., February 1, 2004; 10(3): 964 - 971. [Abstract] [Full Text] [PDF]

				S. C. Robinson, K. A. Scott, J. L. Wilson, R. G. Thompson, A. E. I. Proudfoot, and F. R. Balkwill A Chemokine Receptor Antagonist Inhibits Experimental Breast Tumor Growth Cancer Res., December 1, 2003; 63(23): 8360 - 8365. [Abstract] [Full Text] [PDF]

				T. Schioppa, B. Uranchimeg, A. Saccani, S. K. Biswas, A. Doni, A. Rapisarda, S. Bernasconi, S. Saccani, M. Nebuloni, L. Vago, et al. Regulation of the Chemokine Receptor CXCR4 by Hypoxia J. Exp. Med., November 3, 2003; 198(9): 1391 - 1402. [Abstract] [Full Text] [PDF]

				X. Chen, J. A. Beutler, T. G. McCloud, A. Loehfelm, L. Yang, H.-F. Dong, O. Y. Chertov, R. Salcedo, J. J. Oppenheim, and O. M. Z. Howard Tannic Acid Is an Inhibitor of CXCL12 (SDF-1{alpha})/CXCR4 with Antiangiogenic Activity Clin. Cancer Res., August 1, 2003; 9(8): 3115 - 3123. [Abstract] [Full Text] [PDF]

				Y. Ding, Y. Shimada, M. Maeda, A. Kawabe, J. Kaganoi, I. Komoto, Y. Hashimoto, M. Miyake, H. Hashida, and M. Imamura Association of CC Chemokine Receptor 7 with Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma Clin. Cancer Res., August 1, 2003; 9(9): 3406 - 3412. [Abstract] [Full Text] [PDF]

				I. S. Zeelenberg, L. Ruuls-Van Stalle, and E. Roos The Chemokine Receptor CXCR4 Is Required for Outgrowth of Colon Carcinoma Micrometastases Cancer Res., July 1, 2003; 63(13): 3833 - 3839. [Abstract] [Full Text] [PDF]

				R. J. Phillips, M. D. Burdick, M. Lutz, J. A. Belperio, M. P. Keane, and R. M. Strieter The Stromal Derived Factor-1/CXCL12-CXC Chemokine Receptor 4 Biological Axis in Non-Small Cell Lung Cancer Metastases Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1676 - 1686. [Abstract] [Full Text] [PDF]

				M. Mareel and A. Leroy Clinical, Cellular, and Molecular Aspects of Cancer Invasion Physiol Rev, April 1, 2003; 83(2): 337 - 376. [Abstract] [Full Text] [PDF]

				T. Kijima, G. Maulik, P. C. Ma, E. V. Tibaldi, R. E. Turner, B. Rollins, M. Sattler, B. E. Johnson, and R. Salgia Regulation of Cellular Proliferation, Cytoskeletal Function, and Signal Transduction through CXCR4 and c-Kit in Small Cell Lung Cancer Cells Cancer Res., November 1, 2002; 62(21): 6304 - 6311. [Abstract] [Full Text] [PDF]

				C. J. Scotton, J. L. Wilson, K. Scott, G. Stamp, G. D. Wilbanks, S. Fricker, G. Bridger, and F. R. Balkwill Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer Cancer Res., October 15, 2002; 62(20): 5930 - 5938. [Abstract] [Full Text] [PDF]

				P. Menten, A. Saccani, C. Dillen, A. Wuyts, S. Struyf, P. Proost, A. Mantovani, J. M. Wang, and J. Van Damme Role of the autocrine chemokines MIP-1{alpha} and MIP-1{beta} in the metastatic behavior of murine T cell lymphoma J. Leukoc. Biol., October 1, 2002; 72(4): 780 - 789. [Abstract] [Full Text] [PDF]

				P. Dhawan and A. Richmond Role of CXCL1 in tumorigenesis of melanoma J. Leukoc. Biol., July 1, 2002; 72(1): 9 - 18. [Abstract] [Full Text] [PDF]

				E. Schutyser, S. Struyf, P. Proost, G. Opdenakker, G. Laureys, B. Verhasselt, L. Peperstraete, I. Van de Putte, A. Saccani, P. Allavena, et al. Identification of Biologically Active Chemokine Isoforms from Ascitic Fluid and Elevated Levels of CCL18/Pulmonary and Activation-regulated Chemokine in Ovarian Carcinoma J. Biol. Chem., June 28, 2002; 277(27): 24584 - 24593. [Abstract] [Full Text] [PDF]

				F. Bertolini, C. Dell'Agnola, P. Mancuso, C. Rabascio, A. Burlini, S. Monestiroli, A. Gobbi, G. Pruneri, and G. Martinelli CXCR4 Neutralization, a Novel Therapeutic Approach for Non-Hodgkin's Lymphoma Cancer Res., June 1, 2002; 62(11): 3106 - 3112. [Abstract] [Full Text] [PDF]

				K. Mashino, N. Sadanaga, H. Yamaguchi, F. Tanaka, M. Ohta, K. Shibuta, H. Inoue, and M. Mori Expression of Chemokine Receptor CCR7 Is Associated with Lymph Node Metastasis of Gastric Carcinoma Cancer Res., May 1, 2002; 62(10): 2937 - 2941. [Abstract] [Full Text] [PDF]

				D. Milliken, C. Scotton, S. Raju, F. Balkwill, and J. Wilson Analysis of Chemokines and Chemokine Receptor Expression in Ovarian Cancer Ascites Clin. Cancer Res., April 1, 2002; 8(4): 1108 - 1114. [Abstract] [Full Text] [PDF]

				K. Soejima and B. J. Rollins A Functional IFN-{gamma}-Inducible Protein-10/CXCL10-Specific Receptor Expressed by Epithelial and Endothelial Cells That Is Neither CXCR3 Nor Glycosaminoglycan J. Immunol., December 1, 2001; 167(11): 6576 - 6582. [Abstract] [Full Text] [PDF]