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Dynamic Micro-Magnetic Resonance Imaging of Liver Micrometastasis in Mice with a Novel Liver Macromolecular Magnetic Resonance Contrast Agent DAB-Am64-(1B4M-Gd)₆₄

Department of Diagnostic and Interventional Imagiology² [H. K., K. T.], Department of Nuclear Medicine and Diagnostic Imaging [T. S., N. S., T. I., J. K.], and Department of Radiology [A. H.], Kyoto University, Kyoto 606-8507, Japan; Department of Radiology, Otsu Municipal Hospital, Otsu 520-0804, Japan [S. K.]; and Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH [M. W. B.], Bethesda, Maryland 20892

DAB-Am64-(1B4M-Gd)₆₄ is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)₆₄, which quickly accumulated in the liver, have been reported recently. In the present study, the dynamic micro-MRI with DAB-Am64-(1B4M-Gd)₆₄ was obtained in the mouse liver metastasis model using colon carcinoma cells to evaluate the ability to visualize the micrometastatic tumors compared with that using Gd-DTPA. The dynamic micro-MRI with DAB-Am64-(1B4M-Gd)₆₄ was able to homogeneously enhance the normal liver parenchyma and visualize micrometastatic tumors of 0.3-mm diameter in the liver of the mice with better contrast than that with Gd-DTPA. In conclusion, DAB-Am64-(1B4M-Gd)₆₄ is a new liver MRI contrast agent potentially useful for diagnosis of micrometastasis in the liver.

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