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[Cancer Research 61, 4971-4973, July 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Monitoring Response to Convection-enhanced Taxol Delivery in Brain Tumor Patients Using Diffusion-weighted Magnetic Resonance Imaging1

Yael Mardor, Yiftach Roth, Zvi Lidar, Tali Jonas, Raphael Pfeffer, Stephan E. Maier, Meir Faibel, Dvora Nass, Moshe Hadani, Arie Orenstein, Jack S. Cohen and Zvi Ram2

Advanced Technology Center [Y. M., Y. R., A. O., J. S. C.], Neurosurgery Department [Z. L., M. H., Z. R.], Radiology Department [T. J., M. F.], Oncology Institute [R. P.], Pathology Institute [D. N.], The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel, and Brigham and Women’s Hospital, Harvard University, Boston, Massachusetts 02115 [S. E. M.]

Convection-enhanced drug delivery (CEDD) is a novel approach to enhance the delivery of drugs directly into brain tumors. We have used diffusion-weighted MRI (DWMRI) to monitor the effects of intratumoral CEDD in three brain tumor patients treated with Taxol. Clear changes in the images and the water diffusion parameters were observed shortly after the initiation of treatment. Initially, a bright area corresponding to decreased diffusion appeared, followed by the appearance of a dark area of increased diffusion within the bright area. The time to appearance of the dark area varied among the patients, suggesting different response rates. In this work, we have demonstrated the feasibility of using DWMRI as a noninvasive tool to achieve unique early tissue characterization not attainable by other conventional imaging methods.




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Copyright © 2001 by the American Association for Cancer Research.