Cancer Research Cell Death Mechanisms and Cancer Therapy Telomeres
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Horvath, L. G.
Right arrow Articles by Sutherland, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Horvath, L. G.
Right arrow Articles by Sutherland, R. L.
[Cancer Research 61, 5331-5335, July 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Frequent Loss of Estrogen Receptor-ß Expression in Prostate Cancer1

Lisa G. Horvath, Susan M. Henshall, C-Soon Lee, Darren R. Head, David I. Quinn, Sari Makela, Warick Delprado, David Golovsky, Phillip C. Brenner, Gordon O’Neill, Raji Kooner, Phillip D. Stricker, John J. Grygiel, Jan-Ake Gustafsson and Robert L. Sutherland2

Cancer Research Program, Garvan Institute of Medical Research, [L. G. H., S. M. H., D. R. H., D. I. Q., R. L. S.], and Departments of Urology [D. G., P. C. B., G. O., R. K., P. D. S.] and Medical Oncology [J. J. G.], St. Vincent’s Hospital, Darlinghurst, Sydney, NSW 2010, Australia; Department of Anatomical Pathology, Royal Prince Alfred Hospital and Department of Pathology, University of Sydney, Camperdown, NSW 2050, Australia [C. S. L.]; Department of Medical Nutrition and Biosciences, Karolinska Institute, NOVUM, S-141 86 Huddinge, Sweden [S. M., J-A. G.]; and Douglass Hanly Moir Pathology, North Ryde, NSW 2113, Australia [W. D.]

The role of estrogen and its receptors in the etiology and progression of prostate cancer (PC) is poorly understood. In normal and malignant human prostate, estrogen receptor-{alpha} is expressed only in the stroma, whereas estrogen receptor-ß (ERß) is present in both normal stroma and epithelium. Because loss of ERß expression is associated with prostate hyperplasia in ERß-null mice, this study determined patterns of ERß expression in normal, hyperplastic, and malignant human prostate and associations with clinical outcome. Five normal prostates from organ donors and 159 radical prostatectomy specimens from patients with clinically localized PC were assessed for ERß expression using immunohistochemistry. ERß-positivity was defined as >=5% of cells demonstrating nuclear immunoreactivity. All of the five normal prostates showed strong ERß-nuclear staining in >95% of the epithelium and 35% of the stromal cells. The number of ERß-positive cases declined to 24.2% (38/157) in hyperplasia adjacent to carcinoma and 11.3% (18/159) in PCs. ERß-positivity was related to decreased relapse-free survival (log-rank P = 0.04). Thus, loss of ERß expression is associated with progression from normal prostate epithelium to PC, whereas those cancers that retained ERß expression were associated with a higher rate of recurrence. These data identify the need to further investigate the potential role of ERß in the regulation of prostate epithelial cell proliferation and the functional consequences of decreased ERß expression in the evolution of PC.




This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
M H W Wong, T A Dobbins, J Tseung, N Tran, C S Lee, C J O'Brien, J Clark, and B R Rose
Oestrogen receptor {beta} expression in pleomorphic adenomas of the parotid gland
J. Clin. Pathol., September 1, 2009; 62(9): 789 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
N. Nicolaiew, G. Cancel-Tassin, A. R. Azzouzi, B. L. Grand, P. Mangin, L. Cormier, G. Fournier, J.-P. Giordanella, M. Pouchard, J.-L. Escary, et al.
Association between estrogen and androgen receptor genes and prostate cancer risk
Eur. J. Endocrinol., January 1, 2009; 160(1): 101 - 106.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. Kurahashi, M. Iwasaki, M. Inoue, S. Sasazuki, and S. Tsugane
Plasma Isoflavones and Subsequent Risk of Prostate Cancer in a Nested Case-Control Study: The Japan Public Health Center
J. Clin. Oncol., December 20, 2008; 26(36): 5923 - 5929.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Smith, D. Sepkovic, H. L. Bradlow, and K. J. Auborn
3,3'-Diindolylmethane and Genistein Decrease the Adverse Effects of Estrogen in LNCaP and PC-3 Prostate Cancer Cells
J. Nutr., December 1, 2008; 138(12): 2379 - 2385.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Stettner, S. Kaulfuss, P. Burfeind, S. Schweyer, A. Strauss, R.-H. Ringert, and P. Thelen
The relevance of estrogen receptor-{beta} expression to the antiproliferative effects observed with histone deacetylase inhibitors and phytoestrogens in prostate cancer treatment
Mol. Cancer Ther., October 1, 2007; 6(10): 2626 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
G. P Risbridger, S. J Ellem, and S. J McPherson
Estrogen action on the prostate gland: a critical mix of endocrine and paracrine signaling
J. Mol. Endocrinol., September 1, 2007; 39(3): 183 - 188.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
C. E. Harper, B. B. Patel, J. Wang, A. Arabshahi, I. A. Eltoum, and C. A. Lamartiniere
Resveratrol suppresses prostate cancer progression in transgenic mice
Carcinogenesis, September 1, 2007; 28(9): 1946 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
P. Galluzzo, F. Caiazza, S. Moreno, and M. Marino
Role of ER{beta} palmitoylation in the inhibition of human colon cancer cell proliferation
Endocr. Relat. Cancer, March 1, 2007; 14(1): 153 - 167.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
N. Kurahashi, M. Iwasaki, S. Sasazuki, T. Otani, M. Inoue, S. Tsugane, and Japan Public Health Center-Based Prospective Study
Soy Product and Isoflavone Consumption in Relation to Prostate Cancer in Japanese Men
Cancer Epidemiol. Biomarkers Prev., March 1, 2007; 16(3): 538 - 545.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. Thellenberg-Karlsson, S. Lindstrom, B. Malmer, F. Wiklund, K. Augustsson-Balter, H.-O. Adami, P. Stattin, M. Nilsson, K. Dahlman-Wright, J.-A. Gustafsson, et al.
Estrogen Receptor {beta} Polymorphism Is Associated with Prostate Cancer Risk
Clin. Cancer Res., March 15, 2006; 12(6): 1936 - 1941.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
S. M. Dehm and D. J. Tindall
Editorial Commentary on Zhu et al
J Androl, July 1, 2005; 26(4): 509 - 510.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
L.-C. Li, P. R. Carroll, and R. Dahiya
Epigenetic Changes in Prostate Cancer: Implication for Diagnosis and Treatment
J Natl Cancer Inst, January 19, 2005; 97(2): 103 - 115.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. N. Lauber, S. Ali, and N. J. Gooderham
The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity
Carcinogenesis, December 1, 2004; 25(12): 2509 - 2517.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. M. Selva, O. M. Tirado, N. Toran, C. A. Suarez-Quian, J. Reventos, and F. Munell
Estrogen Receptor {beta} Expression and Apoptosis of Spermatocytes of Mice Overexpressing a Rat Androgen-Binding Protein Transgene
Biol Reprod, November 1, 2004; 71(5): 1461 - 1468.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A Bardin, N Boulle, G Lazennec, F Vignon, and P Pujol
Loss of ER{beta} expression as a common step in estrogen-dependent tumor progression
Endocr. Relat. Cancer, September 1, 2004; 11(3): 537 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. Imamov, A. Morani, G.-J. Shim, Y. Omoto, C. Thulin-Andersson, M. Warner, and J.-A. Gustafsson
Estrogen receptor {beta} regulates epithelial cellular differentiation in the mouse ventral prostate
PNAS, June 22, 2004; 101(25): 9375 - 9380.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Martin, M. Ross, K. E. Chapman, R. Andrew, P. Bollina, J. R. Seckl, and F. K. Habib
CYP7B Generates a Selective Estrogen Receptor {beta} Agonist in Human Prostate
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2928 - 2935.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
F. E. Domann and B. W. Futscher
Flipping the Epigenetic Switch
Am. J. Pathol., June 1, 2004; 164(6): 1883 - 1886.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
X. Zhu, I. Leav, Y.-k. Leung, M. Wu, Q. Liu, Y. Gao, J. E. McNeal, and S.-M. Ho
Dynamic Regulation of Estrogen Receptor-{beta} Expression by DNA Methylation During Prostate Cancer Development and Metastasis
Am. J. Pathol., June 1, 2004; 164(6): 2003 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
A. Cabanes, M. Wang, S. Olivo, S. DeAssis, J.-A. Gustafsson, G. Khan, and L. Hilakivi-Clarke
Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis
Carcinogenesis, May 1, 2004; 25(5): 741 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. G. Horvath, S. M. Henshall, J. G. Kench, D. N. Saunders, C.-S. Lee, D. Golovsky, P. C. Brenner, G. F. O'Neill, R. Kooner, P. D. Stricker, et al.
Membranous Expression of Secreted Frizzled-Related Protein 4 Predicts for Good Prognosis in Localized Prostate Cancer and Inhibits PC3 Cellular Proliferation in Vitro
Clin. Cancer Res., January 15, 2004; 10(2): 615 - 625.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
O. M. Tirado, D. M. Selva, N. Toran, C. A. Suarez-Quian, M. Jansen, D. P. McDonnell, J. Reventos, and F. Munell
Increased Expression of Estrogen Receptor {beta} in Pachytene Spermatocytes After Short-Term Methoxyacetic Acid Administration
J Androl, January 1, 2004; 25(1): 84 - 94.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. L. Ramsey, K. E. Risinger, S. C. Jernigan, K. A. Mattingly, and C. M. Klinge
Estrogen Receptor {beta} Isoforms Exhibit Differences in Ligand-Activated Transcriptional Activity in an Estrogen Response Element Sequence-Dependent Manner
Endocrinology, January 1, 2004; 145(1): 149 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Li, H. Lee, S. Guo, T. G. Unterman, G. Jenster, and W. Bai
AKT-Independent Protection of Prostate Cancer Cells from Apoptosis Mediated through Complex Formation between the Androgen Receptor and FKHR
Mol. Cell. Biol., January 1, 2003; 23(1): 104 - 118.
[Abstract] [Full Text]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. A. Jarred, M. Keikha, C. Dowling, S. J. McPherson, A. M. Clare, A. J. Husband, J. S. Pedersen, M. Frydenberg, and G. P. Risbridger
Induction of Apoptosis in Low to Moderate-Grade Human Prostate Carcinoma by Red Clover-derived Dietary Isoflavones
Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1689 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Weihua, R. Lathe, M. Warner, and J.-A. Gustafsson
An endocrine pathway in the prostate, ERbeta , AR, 5alpha -androstane-3beta ,17beta -diol, and CYP7B1, regulates prostate growth
PNAS, October 15, 2002; 99(21): 13589 - 13594.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-M. Liu, C. Albanese, C. M. Anderson, K. Hilty, P. Webb, R. M. Uht, R. H. Price Jr., R. G. Pestell, and P. J. Kushner
Opposing Action of Estrogen Receptors alpha and beta on Cyclin D1 Gene Expression
J. Biol. Chem., June 28, 2002; 277(27): 24353 - 24360.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
V Speirs, G P Skliris, S E Burdall, and P J Carder
Distinct expression patterns of ER{alpha} and ER{beta} in normal human mammary gland
J. Clin. Pathol., May 1, 2002; 55(5): 371 - 374.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Corey, J. E. Quinn, M. J. Emond, K. R. Buhler, L. G. Brown, and R. L. Vessella
Inhibition of Androgen-independent Growth of Prostate Cancer Xenografts by 17{beta}-Estradiol
Clin. Cancer Res., April 1, 2002; 8(4): 1003 - 1007.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
C. A. Lamartiniere, J. Wang, M. Smith-Johnson, and I.-E. Eltoum
Daidzein: Bioavailability, Potential for Reproductive Toxicity, and Breast Cancer Chemoprevention in Female Rats
Toxicol. Sci., February 1, 2002; 65(2): 228 - 238.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.