Cancer Research Annual Meeting 2010 2010 Workshops
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jones, G.
Right arrow Articles by Merlo, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jones, G.
Right arrow Articles by Merlo, A.
[Cancer Research 61, 5688-5691, August 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

PTEN-independent Induction of Caspase-mediated Cell Death and Reduced Invasion by the Focal Adhesion Targeting Domain (FAT) in Human Astrocytic Brain Tumors Which Highly Express Focal Adhesion Kinase (FAK)1

Graham Jones, Joel Machado, Jr., Markus Tolnay and Adrian Merlo2

Laboratory of Molecular Neuro-Oncology, Department of Clinical and Biological Sciences [G. J., J. M., A. M.], Department of Surgery [A. M.], and the Institute for Pathology [M. T.], University of Basel, 4031 Basel, Switzerland

Increased expression of focal adhesion kinase (FAK) was consistently observed in low- and high-grade astrocytomas and during glioblastoma progression after radiotherapy, but not in the more benign oligodendroglioma. In glioblastoma cell lines deficient for p53, p16INK4A, and p14ARF, FAK was inhibited in a dominant-negative manner by the focal adhesion targeting (FAT) domain, reducing invasion. In addition, caspase-3 activity was increased after serum withdrawal, or by cisplatin in the presence of serum, or upon loss of substrate attachment, and was in each case independent of PTEN status. Our results identify FAK as a potential target for anti-invasive strategies against infiltrating glioma cells.




This article has been cited by other articles:


Home page
 Neuro OncologyHome page
Y. Piao, L. Lu, and J. de Groot
AMPA receptors promote perivascular glioma invasion via {beta}1 integrin-dependent adhesion to the extracellular matrix
Neuro Oncology, June 1, 2009; 11(3): 260 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. Takino, H. Saeki, H. Miyamori, T. Kudo, and H. Sato
Inhibition of Membrane-Type 1 Matrix Metalloproteinase at Cell-Matrix Adhesions
Cancer Res., December 15, 2007; 67(24): 11621 - 11629.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncologyHome page
S. de Bouard, P. Herlin, J. G. Christensen, E. Lemoisson, P. Gauduchon, E. Raymond, and J.-S. Guillamo
Antiangiogenic and anti-invasive effects of sunitinib on experimental human glioblastoma
Neuro Oncology, October 1, 2007; 9(4): 412 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. J. van Nimwegen, M. Huigsloot, A. Camier, I. B. Tijdens, and B. van de Water
Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
Mol. Pharmacol., October 1, 2006; 70(4): 1330 - 1339.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. Halder, C. N. Landen Jr., S. K. Lutgendorf, Y. Li, N. B. Jennings, D. Fan, G. M. Nelkin, R. Schmandt, M. D. Schaller, and A. K. Sood
Focal Adhesion Kinase Silencing Augments Docetaxel-Mediated Apoptosis in Ovarian Cancer Cells
Clin. Cancer Res., December 15, 2005; 11(24): 8829 - 8836.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Park, I. Han, H. J. Kwon, and E.-S. Oh
Focal Adhesion Kinase Regulates Syndecan-2-Mediated Tumorigenic Activity of HT1080 Fibrosarcoma Cells
Cancer Res., November 1, 2005; 65(21): 9899 - 9905.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. J. Riemenschneider, W. Mueller, R. A. Betensky, G. Mohapatra, and D. N. Louis
In Situ Analysis of Integrin and Growth Factor Receptor Signaling Pathways in Human Glioblastomas Suggests Overlapping Relationships with Focal Adhesion Kinase Activation
Am. J. Pathol., November 1, 2005; 167(5): 1379 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
A. Merlo and B. Bettler
Glioblastomas on the Move
Sci. Signal., April 20, 2004; 2004(229): pe18 - pe18.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M.-J. Park, M.-S. Kim, I.-C. Park, H.-S. Kang, H. Yoo, S. H. Park, C. H. Rhee, S.-I. Hong, and S.-H. Lee
PTEN Suppresses Hyaluronic Acid-induced Matrix Metalloproteinase-9 Expression in U87MG Glioblastoma Cells through Focal Adhesion Kinase Dephosphorylation
Cancer Res., November 1, 2002; 62(21): 6318 - 6322.
[Abstract] [Full Text] [PDF]

Home page
 Neuro OncologyHome page
C. B. Knobbe, A. Merlo, and G. Reifenberger
Pten signaling in gliomas
Neuro Oncology, July 1, 2002; 4(3): 196 - 211.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
W. Wick, A. Wick, J. B. Schulz, J. Dichgans, H. P. Rodemann, and M. Weller
Prevention of Irradiation-induced Glioma Cell Invasion by Temozolomide Involves Caspase 3 Activity and Cleavage of Focal Adhesion Kinase
Cancer Res., March 1, 2002; 62(6): 1915 - 1919.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.