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[Cancer Research 61, 5692-5696, August 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer1

Jeffrey A. Magee, Toshiyuki Araki, Sushama Patil, Torsten Ehrig, Lawrence True, Peter A. Humphrey, William J. Catalona, Mark A. Watson and Jeffrey Milbrandt2

Department of Pathology, Divisions of Laboratory Medicine [J. A. M., T. A., S. P., T. E., P. A. H., M. A. W., J. M.] and Department of Surgery, Division of Urology [W. J. C.], Washington University School of Medicine, St. Louis, Missouri 63110, and Department of Pathology, University of Washington Medical Center, Seattle, Washington 98195 [L. T.]

Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that coincide with prostate cancer progression remain enigmatic. We have addressed this problem by characterizing the expression profiles of several benign and malignant human prostate samples, and we have identified several genes that are differentially expressed between benign and malignant glands. One gene that was overexpressed encodes the serine protease hepsin. We used an independent sample set to confirm that hepsin is overexpressed in prostate tumors, and in situ hybridization demonstrates that hepsin is specifically overexpressed in the carcinoma cells themselves. These facts, together with the molecular properties of hepsin, make it an ideal target for prostate cancer therapy.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.