Cancer Research Infection and Cancer: Biology, Therapeutics, and Prevention Translational Medicine Conference in Israel
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bachelder, R. E.
Right arrow Articles by Mercurio, A. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bachelder, R. E.
Right arrow Articles by Mercurio, A. M.
[Cancer Research 61, 5736-5740, August 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Vascular Endothelial Growth Factor Is an Autocrine Survival Factor for Neuropilin-expressing Breast Carcinoma Cells1

Robin E. Bachelder2, Aimee Crago2, Jun Chung, Melissa A. Wendt, Leslie M. Shaw, Gregory Robinson3 and Arthur M. Mercurio4

Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School [R. E. B., A. C., J. C., M. A. W., L. M. S., A. M. M.], and Department of Ophthalmology, The Children’s Hospital [G. R.], Boston, Massachusetts 02215

We identify a novel function for the vascular endothelial growth factor (VEGF) in its ability to stimulate an autocrine signaling pathway in metastatic breast carcinoma cells that is essential for their survival. Suppression of VEGF expression in metastatic cells in vitro induced their apoptosis, in addition to inhibiting the constitutively elevated phosphatidylinositol 3'-kinase activity that is characteristic of these cells and important for their survival. Hypoxia enhanced the survival of metastatic cells by increasing VEGF expression. The importance of the VEGF receptor neuropilin was indicated by the ability of a neuropilin-binding VEGF isoform to enhance breast carcinoma survival. Moreover, the expression of neuropilin in neuropilin-deficient breast carcinoma cells protected them from apoptosis. The identification of this VEGF autocrine signaling pathway has important implications for tumor metastasis and therapeutic intervention.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
Z. Qu, S. Van Ginkel, A. M. Roy, L. Westbrook, M. Nasrin, Y. Maxuitenko, A. R. Frost, D. Carey, W. Wang, R. Li, et al.
Vascular Endothelial Growth Factor Reduces Tamoxifen Efficacy and Promotes Metastatic Colonization and Desmoplasia in Breast Tumors
Cancer Res., August 1, 2008; 68(15): 6232 - 6240.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
Z. Belaid-Choucair, Y. Lepelletier, G. Poncin, A. Thiry, C. Humblet, M. Maachi, A. Beaulieu, E. Schneider, A. Briquet, P. Mineur, et al.
Human Bone Marrow Adipocytes Block Granulopoiesis Through Neuropilin-1-Induced Granulocyte Colony-Stimulating Factor Inhibition
Stem Cells, June 1, 2008; 26(6): 1556 - 1564.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. N. Korgaonkar, X. Feng, M. D. Ross, T.-c. Lu, V. D'Agati, R. Iyengar, P. E. Klotman, and J. C. He
HIV-1 Upregulates VEGF in Podocytes
J. Am. Soc. Nephrol., May 1, 2008; 19(5): 877 - 883.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Sulpice, J. Plouet, M. Berge, D. Allanic, G. Tobelem, and T. Merkulova-Rainon
Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity
Blood, February 15, 2008; 111(4): 2036 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. Chakraborty, S. Jain, and G. C. Kundu
Osteopontin Promotes Vascular Endothelial Growth Factor Dependent Breast Tumor Growth and Angiogenesis via Autocrine and Paracrine Mechanisms
Cancer Res., January 1, 2008; 68(1): 152 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M.-A. Herve, H. Buteau-Lozano, R. Vassy, I. Bieche, G. Velasco, M. Pla, G. Perret, S. Mourah, and M. Perrot-Applanat
Overexpression of Vascular Endothelial Growth Factor 189 in Breast Cancer Cells Leads to Delayed Tumor Uptake with Dilated Intratumoral Vessels
Am. J. Pathol., January 1, 2008; 172(1): 167 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. R. Emlet, K. A. Brown, D. L. Kociban, A. A. Pollice, C. A. Smith, B. B. L. Ong, and S. E. Shackney
Response to trastuzumab, erlotinib, and bevacizumab, alone and in combination, is correlated with the level of human epidermal growth factor receptor-2 expression in human breast cancer cell lines
Mol. Cancer Ther., October 1, 2007; 6(10): 2664 - 2674.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T.-M. Hong, Y.-L. Chen, Y.-Y. Wu, A. Yuan, Y.-C. Chao, Y.-C. Chung, M.-H. Wu, S.-C. Yang, S.-H. Pan, J.-Y. Shih, et al.
Targeting Neuropilin 1 as an Antitumor Strategy in Lung Cancer
Clin. Cancer Res., August 15, 2007; 13(16): 4759 - 4768.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Z. Ma, S. L. Gibson, M. A. Byrne, J. Zhang, M. F. White, and L. M. Shaw
Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis
Mol. Cell. Biol., December 15, 2006; 26(24): 9338 - 9351.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Chen, J. Lin, T. Kanekura, J. Su, W. Lin, H. Xie, Y. Wu, J. Li, M. Chen, and J. Chang
A Small Interfering CD147-Targeting RNA Inhibited the Proliferation, Invasiveness, and Metastatic Activity of Malignant Melanoma
Cancer Res., December 1, 2006; 66(23): 11323 - 11330.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-U. Kim, S. S. Kang, S.-A. Yoo, K.-H. Hong, D.-G. Bae, M.-S. Lee, S. W. Hong, C.-B. Chae, and C.-S. Cho
Interaction of Vascular Endothelial Growth Factor 165 with Neuropilin-1 Protects Rheumatoid Synoviocytes from Apoptotic Death by Regulating Bcl-2 Expression and Bax Translocation
J. Immunol., October 15, 2006; 177(8): 5727 - 5735.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Z. Yang, L. E. Harris, D. E. Palmer-Toy, and W. S. Hancock
Multilectin Affinity Chromatography for Characterization of Multiple Glycoprotein Biomarker Candidates in Serum from Breast Cancer Patients
Clin. Chem., October 1, 2006; 52(10): 1897 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Q.-D. Nguyen, S. Rodrigues, C. M. Rodrigue, C. Rivat, C. Grijelmo, E. Bruyneel, S. Emami, S. Attoub, and C. Gespach
Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts.
Mol. Cancer Ther., August 1, 2006; 5(8): 2070 - 2077.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
B Zhao, A Ma, J Cai, and M Boulton
VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells
Br. J. Ophthalmol., August 1, 2006; 90(8): 1052 - 1059.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. J. Kang, H. J. Kim, J.-K. Rih, T. L. Mattson, K. W. Kim, C.-H. Cho, J. S. Isaacs, and I. Bae
BRCA1 Plays a Role in the Hypoxic Response by Regulating HIF-1{alpha} Stability and by Modulating Vascular Endothelial Growth Factor Expression
J. Biol. Chem., May 12, 2006; 281(19): 13047 - 13056.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
L. M. Ellis
The role of neuropilins in cancer
Mol. Cancer Ther., May 1, 2006; 5(5): 1099 - 1107.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
A. L. Mulkeen, T. Silva, P. S. Yoo, J. C. Schmitz, E. Uchio, E. Chu, and C. Cha
Short Interfering RNA-Mediated Gene Silencing of Vascular Endothelial Growth Factor: Effects on Cellular Proliferation in Colon Cancer Cells
Arch Surg, April 1, 2006; 141(4): 367 - 374.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. du Manoir, G. Francia, S. Man, M. Mossoba, J. A. Medin, A. Viloria-Petit, D. J. Hicklin, U. Emmenegger, and R. S. Kerbel
Strategies for Delaying or Treating In vivo Acquired Resistance to Trastuzumab in Human Breast Cancer Xenografts
Clin. Cancer Res., February 1, 2006; 12(3): 904 - 916.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. A. Lipscomb, K. J. Simpson, S. R. Lyle, J. E. Ring, A. S. Dugan, and A. M. Mercurio
The {alpha}6{beta}4 Integrin Maintains the Survival of Human Breast Carcinoma Cells In vivo
Cancer Res., December 1, 2005; 65(23): 10970 - 10976.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. J. Gray, J. S. Wey, A. Belcheva, M. F. McCarty, J. G. Trevino, D. B. Evans, L. M. Ellis, and G. E. Gallick
Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors
Cancer Res., May 1, 2005; 65(9): 3664 - 3670.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Murga, O. Fernandez-Capetillo, and G. Tosato
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
Blood, March 1, 2005; 105(5): 1992 - 1999.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Brusselmans, F. Bono, D. Collen, J.-M. Herbert, P. Carmeliet, and M. Dewerchin
A Novel Role for Vascular Endothelial Growth Factor as an Autocrine Survival Factor for Embryonic Stem Cells during Hypoxia
J. Biol. Chem., February 4, 2005; 280(5): 3493 - 3499.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Kryczek, A. Lange, P. Mottram, X. Alvarez, P. Cheng, M. Hogan, L. Moons, S. Wei, L. Zou, V. Machelon, et al.
CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers
Cancer Res., January 15, 2005; 65(2): 465 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. R. Foster, M. A. Saleem, P. W. Mathieson, D. O. Bates, and S. J. Harper
Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
Am J Physiol Renal Physiol, January 1, 2005; 288(1): F48 - F57.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Woolard, W.-Y. Wang, H. S. Bevan, Y. Qiu, L. Morbidelli, R. O. Pritchard-Jones, T.-G. Cui, M. Sugiono, E. Waine, R. Perrin, et al.
VEGF165b, an Inhibitory Vascular Endothelial Growth Factor Splice Variant: Mechanism of Action, In vivo Effect On Angiogenesis and Endogenous Protein Expression
Cancer Res., November 1, 2004; 64(21): 7822 - 7835.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. S. Wang, J. Teruya-Feldstein, Y. Wu, Z. Zhu, D. J. Hicklin, and M. A. S. Moore
Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
Blood, November 1, 2004; 104(9): 2893 - 2902.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Castro-Rivera, S. Ran, P. Thorpe, and J. D. Minna
Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect
PNAS, August 3, 2004; 101(31): 11432 - 11437.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. K. Lee, N. D. Bone, A. K. Strege, T. D. Shanafelt, D. F. Jelinek, and N. E. Kay
VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia
Blood, August 1, 2004; 104(3): 788 - 794.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Chung, S. Yoon, K. Datta, R. E. Bachelder, and A. M. Mercurio
Hypoxia-Induced Vascular Endothelial Growth Factor Transcription and Protection from Apoptosis Are Dependent on {alpha}6{beta}1 Integrin in Breast Carcinoma Cells
Cancer Res., July 15, 2004; 64(14): 4711 - 4716.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. A. Parikh, F. Fan, W. B. Liu, S. A. Ahmad, O. Stoeltzing, N. Reinmuth, D. Bielenberg, C. D. Bucana, M. Klagsbrun, and L. M. Ellis
Neuropilin-1 in Human Colon Cancer: Expression, Regulation, and Role in Induction of Angiogenesis
Am. J. Pathol., June 1, 2004; 164(6): 2139 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Fukasawa and M. Korc
Vascular Endothelial Growth Factor-Trap Suppresses Tumorigenicity of Multiple Pancreatic Cancer Cell Lines
Clin. Cancer Res., May 15, 2004; 10(10): 3327 - 3332.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
E. Zelzer, R. Mamluk, N. Ferrara, R. S. Johnson, E. Schipani, and B. R. Olsen
VEGFA is necessary for chondrocyte survival during bone development
Development, May 1, 2004; 131(9): 2161 - 2171.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. A. DeClerck, A. M. Mercurio, M. S. Stack, H. A. Chapman, M. M. Zutter, R. J. Muschel, A. Raz, L. M. Matrisian, B. F. Sloane, A. Noel, et al.
Proteases, Extracellular Matrix, and Cancer: A Workshop of the Path B Study Section
Am. J. Pathol., April 1, 2004; 164(4): 1131 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Fukahi, M. Fukasawa, G. Neufeld, J. Itakura, and M. Korc
Aberrant Expression of Neuropilin-1 and -2 in Human Pancreatic Cancer Cells
Clin. Cancer Res., January 15, 2004; 10(2): 581 - 590.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. G. Oshima, J. Lesperance, V. Munoz, L. Hebbard, B. Ranscht, N. Sharan, W. J. Muller, C. A. Hauser, and R. D. Cardiff
Angiogenic Acceleration of Neu Induced Mammary Tumor Progression and Metastasis
Cancer Res., January 1, 2004; 64(1): 169 - 179.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wang, H. Zeng, P. Wang, S. Soker, and D. Mukhopadhyay
Neuropilin-1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor-dependent Endothelial Cell Migration
J. Biol. Chem., December 5, 2003; 278(49): 48848 - 48860.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. F. Meresman, M. A. Bilotas, E. Lombardi, M. Tesone, C. Sueldo, and R. I. Baranao
Effect of GnRH analogues on apoptosis and release of interleukin-1{beta} and vascular endothelial growth factor in endometrial cell cultures from patients with endometriosis
Hum. Reprod., September 1, 2003; 18(9): 1767 - 1771.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. E. Bachelder, E. A. Lipscomb, X. Lin, M. A. Wendt, N. H. Chadborn, B. J. Eickholt, and A. M. Mercurio
Competing Autocrine Pathways Involving Alternative Neuropilin-1 Ligands Regulate Chemotaxis of Carcinoma Cells
Cancer Res., September 1, 2003; 63(17): 5230 - 5233.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Guo, Q. Fang, H.-Q. Tao, C. A. Schafer, B. M. Fenton, I. Ding, B. Hu, and S.-Y. Cheng
Overexpression of Vascular Endothelial Growth Factor by MCF-7 Breast Cancer Cells Promotes Estrogen-independent Tumor Growth in Vivo
Cancer Res., August 1, 2003; 63(15): 4684 - 4691.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. R. Foster, R. Hole, K. Anderson, S. C. Satchell, R. J. Coward, P. W. Mathieson, D. A. Gillatt, M. A. Saleem, D. O. Bates, and S. J. Harper
Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1263 - F1273.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A Giatromanolaki, E Sivridis, E Maltezos, D Papazoglou, C Simopoulos, K C Gatter, A L Harris, and M I Koukourakis
Hypoxia inducible factor 1{alpha} and 2{alpha} overexpression in inflammatory bowel disease
J. Clin. Pathol., March 1, 2003; 56(3): 209 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T.-H. Lee, H. K. Avraham, S. Jiang, and S. Avraham
Vascular Endothelial Growth Factor Modulates the Transendothelial Migration of MDA-MB-231 Breast Cancer Cells through Regulation of Brain Microvascular Endothelial Cell Permeability
J. Biol. Chem., February 7, 2003; 278(7): 5277 - 5284.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
K. D. Miller, C. J. Sweeney, and G. W. Sledge
The Snark is a Boojum: the continuing problem of drug resistance in the antiangiogenic era
Ann. Onc., January 1, 2003; 14(1): 20 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. E. Bachelder, M. A. Wendt, and A. M. Mercurio
Vascular Endothelial Growth Factor Promotes Breast Carcinoma Invasion in an Autocrine Manner by Regulating the Chemokine Receptor CXCR4
Cancer Res., December 15, 2002; 62(24): 7203 - 7206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Zhang, N. Yang, J.-R. Conejo Garcia, A. Mohamed, F. Benencia, S. C. Rubin, D. Allman, and G. Coukos
Generation of a Syngeneic Mouse Model to Study the Effects of Vascular Endothelial Growth Factor in Ovarian Carcinoma
Am. J. Pathol., December 1, 2002; 161(6): 2295 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
H. F. Dvorak
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy
J. Clin. Oncol., November 1, 2002; 20(21): 4368 - 4380.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Stopeck, M. Sheldon, M. Vahedian, G. Cropp, R. Gosalia, and A. Hannah
Results of a Phase I Dose-escalating Study of the Antiangiogenic Agent, SU5416, in Patients with Advanced Malignancies
Clin. Cancer Res., September 1, 2002; 8(9): 2798 - 2805.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. R. Wedge, D. J. Ogilvie, M. Dukes, J. Kendrew, R. Chester, J. A. Jackson, S. J. Boffey, P. J. Valentine, J. O. Curwen, H. L. Musgrove, et al.
ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration
Cancer Res., August 15, 2002; 62(16): 4645 - 4655.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. A. Masso-Welch, D. Zangani, C. Ip, M. M. Vaughan, S. Shoemaker, R. A. Ramirez, and M. M. Ip
Inhibition of Angiogenesis by the Cancer Chemopreventive Agent Conjugated Linoleic Acid
Cancer Res., August 1, 2002; 62(15): 4383 - 4389.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
J. Chung, R. E. Bachelder, E. A. Lipscomb, L. M. Shaw, and A. M. Mercurio
Integrin ({alpha}6{beta}4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
J. Cell Biol., July 8, 2002; 158(1): 165 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. Pleasure, P. Bannerman, J. Ara, M. Scarlato, and T. Itoh
Prospects for Vascular Endothelial Growth Factor Neurotherapeutics
Arch Neurol, May 1, 2002; 59(5): 692 - 694.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Tomizawa, Y. Sekido, M. Kondo, B. Gao, J. Yokota, J. Roche, H. Drabkin, M. I. Lerman, A. F. Gazdar, and J. D. Minna
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B
PNAS, November 20, 2001; 98(24): 13954 - 13959.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2001 by the American Association for Cancer Research.