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Advances in Brief |
Genomics Institute of the Novartis Research Foundation, San Diego, California 92121 [J. B. W., L. M. S., S. G. K., G. M. H.]; The Scripps Research Institute, La Jolla, California 92037 [A. I. S.]; Department of Pathology, University of California, San Diego, La Jolla, California 92093 [J. W-R.]; and Department of Pathology, University of Virginia, Charlottesville, Virginia 22908 [C. A. M., H. F. F.]
Detection, treatment, and prediction of outcome for men with prostate cancer increasingly depend on a molecular understanding of tumor development and behavior. We characterized primary prostate cancer by monitoring expression levels of more than 8900 genes in normal and malignant tissues. Patterns of gene expression across tissues revealed a precise distinction between normal and tumor samples, and revealed a striking group of about 400 genes that were overexpressed in tumor tissues. We ranked these genes according to their differential expression in normal and cancer tissues by selecting for highly and specifically overexpressed genes in the majority of cancers with correspondingly low or absent expression in normal tissues. Several such genes were identified that act within a variety of biochemical pathways and encode secreted molecules with diagnostic potential, such as the secreted macrophage inhibitory cytokine, MIC-1. Other genes, such as fatty acid synthase, encode enzymes known as drug targets in other contexts, which suggests new therapeutic approaches.
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S Tozlu, I Girault, S Vacher, J Vendrell, C Andrieu, F Spyratos, P Cohen, R Lidereau, and I Bieche Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach Endocr. Relat. Cancer, December 1, 2006; 13(4): 1109 - 1120. [Abstract] [Full Text] [PDF] |
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Z. Li, M. Szabolcs, J. D. Terwilliger, and A. Efstratiadis Prostatic intraepithelial neoplasia and adenocarcinoma in mice expressing a probasin-Neu oncogenic transgene Carcinogenesis, May 1, 2006; 27(5): 1054 - 1067. [Abstract] [Full Text] [PDF] |
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H.-R. Li, J. Wang-Rodriguez, T. M. Nair, J. M. Yeakley, Y.-S. Kwon, M. Bibikova, C. Zheng, L. Zhou, K. Zhang, T. Downs, et al. Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Res., April 15, 2006; 66(8): 4079 - 4088. [Abstract] [Full Text] [PDF] |
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J.-A. Xuan, D. Schneider, P. Toy, R. Lin, A. Newton, Y. Zhu, S. Finster, D. Vogel, B. Mintzer, H. Dinter, et al. Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture. Cancer Res., April 1, 2006; 66(7): 3611 - 3619. [Abstract] [Full Text] [PDF] |
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D. K. Vanaja, K. V. Ballman, B. W. Morlan, J. C. Cheville, R. M. Neumann, M. M. Lieber, D. J. Tindall, and C. Y.F. Young PDLIM4 Repression by Hypermethylation as a Potential Biomarker for Prostate Cancer Clin. Cancer Res., February 15, 2006; 12(4): 1128 - 1136. [Abstract] [Full Text] [PDF] |
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S. Nanni, C. Priolo, A. Grasselli, M. D'Eletto, R. Merola, F. Moretti, M. Gallucci, P. De Carli, S. Sentinelli, A. M. Cianciulli, et al. Epithelial-Restricted Gene Profile of Primary Cultures from Human Prostate Tumors: A Molecular Approach to Predict Clinical Behavior of Prostate Cancer Mol. Cancer Res., February 1, 2006; 4(2): 79 - 92. [Abstract] [Full Text] [PDF] |
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S. P. Duggan, W. M. Gallagher, E. J.P. Fox, M. M. Abdel-Latif, J. V. Reynolds, and D. Kelleher Low pH induces co-ordinate regulation of gene expression in oesophageal cells Carcinogenesis, February 1, 2006; 27(2): 319 - 327. [Abstract] [Full Text] [PDF] |
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E. M. Vestergaard, M. Borre, S. S. Poulsen, E. Nexo, and N. Torring Plasma Levels of Trefoil Factors are Increased in Patients with Advanced Prostate Cancer Clin. Cancer Res., February 1, 2006; 12(3): 807 - 812. [Abstract] [Full Text] [PDF] |
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J. Koopmann, C. N. W. Rosenzweig, Z. Zhang, M. I. Canto, D. A. Brown, M. Hunter, C. Yeo, D. W. Chan, S. N. Breit, and M. Goggins Serum Markers in Patients with Resectable Pancreatic Adenocarcinoma: Macrophage Inhibitory Cytokine 1 versus CA19-9 Clin. Cancer Res., January 15, 2006; 12(2): 442 - 446. [Abstract] [Full Text] [PDF] |
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D. A. Brown, C. Stephan, R. L. Ward, M. Law, M. Hunter, A. R. Bauskin, J. Amin, K. Jung, E. P. Diamandis, G. M. Hampton, et al. Measurement of Serum Levels of Macrophage Inhibitory Cytokine 1 Combined with Prostate-Specific Antigen Improves Prostate Cancer Diagnosis Clin. Cancer Res., January 1, 2006; 12(1): 89 - 96. [Abstract] [Full Text] [PDF] |
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S. A. Tomlins, D. R. Rhodes, S. Perner, S. M. Dhanasekaran, R. Mehra, X.-W. Sun, S. Varambally, X. Cao, J. Tchinda, R. Kuefer, et al. Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer Science, October 28, 2005; 310(5748): 644 - 648. [Abstract] [Full Text] [PDF] |
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I. M. Berquin, Y. Min, R. Wu, H. Wu, and Y. Q. Chen Expression Signature of the Mouse Prostate J. Biol. Chem., October 28, 2005; 280(43): 36442 - 36451. [Abstract] [Full Text] [PDF] |
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A. C. Tan, D. Q. Naiman, L. Xu, R. L. Winslow, and D. Geman Simple decision rules for classifying human cancers from gene expression profiles Bioinformatics, October 15, 2005; 21(20): 3896 - 3904. [Abstract] [Full Text] [PDF] |
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L. Xu, A. C. Tan, D. Q. Naiman, D. Geman, and R. L. Winslow Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data Bioinformatics, October 15, 2005; 21(20): 3905 - 3911. [Abstract] [Full Text] [PDF] |
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C. J.M. Best, J. W. Gillespie, Y. Yi, G. V.R. Chandramouli, M. A. Perlmutter, Y. Gathright, H. S. Erickson, L. Georgevich, M. A. Tangrea, P. H. Duray, et al. Molecular Alterations in Primary Prostate Cancer after Androgen Ablation Therapy Clin. Cancer Res., October 1, 2005; 11(19): 6823 - 6834. [Abstract] [Full Text] [PDF] |
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X. Wang, J. Yu, A. Sreekumar, S. Varambally, R. Shen, D. Giacherio, R. Mehra, J. E. Montie, K. J. Pienta, M. G. Sanda, et al. Autoantibody Signatures in Prostate Cancer N. Engl. J. Med., September 22, 2005; 353(12): 1224 - 1235. [Abstract] [Full Text] [PDF] |
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M. Goggins Molecular Markers of Early Pancreatic Cancer J. Clin. Oncol., July 10, 2005; 23(20): 4524 - 4531. [Abstract] [Full Text] [PDF] |
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A. R. Bauskin, D. A. Brown, S. Junankar, K. K. Rasiah, S. Eggleton, M. Hunter, T. Liu, D. Smith, T. Kuffner, G. J. Pankhurst, et al. The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome Cancer Res., March 15, 2005; 65(6): 2330 - 2336. [Abstract] [Full Text] [PDF] |
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D M Peehl Primary cell cultures as models of prostate cancer development Endocr. Relat. Cancer, March 1, 2005; 12(1): 19 - 47. [Abstract] [Full Text] [PDF] |
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A. Santamaria, E. Castellanos, V. Gomez, P. Benedit, J. Renau-Piqueras, J. Morote, J. Reventos, T. M. Thomson, and R. Paciucci PTOV1 Enables the Nuclear Translocation and Mitogenic Activity of Flotillin-1, a Major Protein of Lipid Rafts Mol. Cell. Biol., March 1, 2005; 25(5): 1900 - 1911. [Abstract] [Full Text] [PDF] |
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S. J. Baek, J.-S. Kim, F. R. Jackson, T. E. Eling, M. F. McEntee, and S.-H. Lee Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells Carcinogenesis, December 1, 2004; 25(12): 2425 - 2432. [Abstract] [Full Text] [PDF] |
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J. P. Hobson, S. Netzel-Arnett, R. Szabo, S. M. Rehault, F. C. Church, D. K. Strickland, D. A. Lawrence, T. M. Antalis, and T. H. Bugge Mouse DESC1 Is Located within a Cluster of Seven DESC1-like Genes and Encodes a Type II Transmembrane Serine Protease That Forms Serpin Inhibitory Complexes J. Biol. Chem., November 5, 2004; 279(45): 46981 - 46994. [Abstract] [Full Text] [PDF] |
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B. E. Nicholson, H. F. Frierson, M. R. Conaway, J. M. Seraj, M. A. Harding, G. M. Hampton, and D. Theodorescu Profiling the Evolution of Human Metastatic Bladder Cancer Cancer Res., November 1, 2004; 64(21): 7813 - 7821. [Abstract] [Full Text] [PDF] |
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M. Bibikova, D. Talantov, E. Chudin, J. M. Yeakley, J. Chen, D. Doucet, E. Wickham, D. Atkins, D. Barker, M. Chee, et al. Quantitative Gene Expression Profiling in Formalin-Fixed, Paraffin-Embedded Tissues Using Universal Bead Arrays Am. J. Pathol., November 1, 2004; 165(5): 1799 - 1807. [Abstract] [Full Text] [PDF] |
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T. J. Jang, H. J. Kang, J. R. Kim, and C. H. Yang Non-steroidal anti-inflammatory drug activated gene (NAG-1) expression is closely related to death receptor-4 and -5 induction, which may explain sulindac sulfide induced gastric cancer cell apoptosis Carcinogenesis, October 1, 2004; 25(10): 1853 - 1858. [Abstract] [Full Text] [PDF] |
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R. Foley, D. Hollywood, and M. Lawler Molecular pathology of prostate cancer: the key to identifying new biomarkers of disease Endocr. Relat. Cancer, September 1, 2004; 11(3): 477 - 488. [Abstract] [Full Text] [PDF] |
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D. E.H. Afar, V. Bhaskar, E. Ibsen, D. Breinberg, S. M. Henshall, J. G. Kench, M. Drobnjak, R. Powers, M. Wong, F. Evangelista, et al. Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer Mol. Cancer Ther., August 1, 2004; 3(8): 921 - 932. [Abstract] [Full Text] [PDF] |
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A. M. Velasco, K. A. Gillis, Y. Li, E. L. Brown, T. M. Sadler, M. Achilleos, L. M. Greenberger, P. Frost, W. Bai, and Y. Zhang Identification and Validation of Novel Androgen-Regulated Genes in Prostate Cancer Endocrinology, August 1, 2004; 145(8): 3913 - 3924. [Abstract] [Full Text] [PDF] |
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Y. P. Yu, D. Landsittel, L. Jing, J. Nelson, B. Ren, L. Liu, C. McDonald, R. Thomas, R. Dhir, S. Finkelstein, et al. Gene Expression Alterations in Prostate Cancer Predicting Tumor Aggression and Preceding Development of Malignancy J. Clin. Oncol., July 15, 2004; 22(14): 2790 - 2799. [Abstract] [Full Text] [PDF] |
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D. R. Rhodes, J. Yu, K. Shanker, N. Deshpande, R. Varambally, D. Ghosh, T. Barrette, A. Pandey, and A. M. Chinnaiyan Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression PNAS, June 22, 2004; 101(25): 9309 - 9314. [Abstract] [Full Text] [PDF] |
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A. Sreekumar, B. Laxman, D. R. Rhodes, S. Bhagavathula, J. Harwood, D. Giacherio, D. Ghosh, M. G. Sanda, M. A. Rubin, and A. M. Chinnaiyan Humoral Immune Response to {alpha}-Methylacyl-CoA Racemase and Prostate Cancer J Natl Cancer Inst, June 2, 2004; 96(11): 834 - 843. [Abstract] [Full Text] [PDF] |
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M. A. Rubin, S. Varambally, R. Beroukhim, S. A. Tomlins, D. R. Rhodes, P. L. Paris, M. D. Hofer, M. Storz-Schweizer, R. Kuefer, J. A. Fletcher, et al. Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer Cancer Res., June 1, 2004; 64(11): 3814 - 3822. [Abstract] [Full Text] [PDF] |
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E. P. Diamandis How Are We Going to Discover New Cancer Biomarkers? A Proteomic Approach for Bladder Cancer Clin. Chem., May 1, 2004; 50(5): 793 - 795. [Full Text] [PDF] |
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E. P. Diamandis Mass Spectrometry as a Diagnostic and a Cancer Biomarker Discovery Tool: Opportunities and Potential Limitations Mol. Cell. Proteomics, April 1, 2004; 3(4): 367 - 378. [Abstract] [Full Text] [PDF] |
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J. Koopmann, P. Buckhaults, D. A. Brown, M. L. Zahurak, N. Sato, N. Fukushima, L. J. Sokoll, D. W. Chan, C. J. Yeo, R. H. Hruban, et al. Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers Clin. Cancer Res., April 1, 2004; 10(7): 2386 - 2392. [Abstract] [Full Text] [PDF] |
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C. Kumar-Sinha, R. B. Shah, B. Laxman, S. A. Tomlins, J. Harwood, W. Schmitz, E. Conzelmann, M. G. Sanda, J. T. Wei, M. A. Rubin, et al. Elevated {alpha}-Methylacyl-CoA Racemase Enzymatic Activity in Prostate Cancer Am. J. Pathol., March 1, 2004; 164(3): 787 - 793. [Abstract] [Full Text] [PDF] |
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J. Lapointe, C. Li, J. P. Higgins, M. van de Rijn, E. Bair, K. Montgomery, M. Ferrari, L. Egevad, W. Rayford, U. Bergerheim, et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer PNAS, January 20, 2004; 101(3): 811 - 816. [Abstract] [Full Text] [PDF] |
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R. O. Stuart, W. Wachsman, C. C. Berry, J. Wang-Rodriguez, L. Wasserman, I. Klacansky, D. Masys, K. Arden, S. Goodison, M. McClelland, et al. In silico dissection of cell-type-associated patterns of gene expression in prostate cancer PNAS, January 13, 2004; 101(2): 615 - 620. [Abstract] [Full Text] [PDF] |
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A J Evans {alpha}-Methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies J. Clin. Pathol., December 1, 2003; 56(12): 892 - 897. [Abstract] [Full Text] [PDF] |
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N. Schulke, O. A. Varlamova, G. P. Donovan, D. Ma, J. P Gardner, D. M. Morrissey, R. R. Arrigale, C. Zhan, A. J. Chodera, K. G. Surowitz, et al. The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy PNAS, October 28, 2003; 100(22): 12590 - 12595. [Abstract] [Full Text] [PDF] |
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J. L. Tanyi, Y. Hasegawa, R. Lapushin, A. J. Morris, J. K. Wolf, A. Berchuck, K. Lu, D. I. Smith, K. Kalli, L. C. Hartmann, et al. Role of Decreased Levels of Lipid Phosphate Phosphatase-1 in Accumulation of Lysophosphatidic Acid in Ovarian Cancer Clin. Cancer Res., September 1, 2003; 9(10): 3534 - 3545. [Abstract] [Full Text] [PDF] |
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T. Liu, A. R. Bauskin, J. Zaunders, D. A. Brown, S. Pankurst, P. J. Russell, and S. N. Breit Macrophage Inhibitory Cytokine 1 Reduces Cell Adhesion and Induces Apoptosis in Prostate Cancer Cells Cancer Res., August 15, 2003; 63(16): 5034 - 5040. [Abstract] [Full Text] [PDF] |
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W.A. Schulz, M. Burchardt, and M.V. Cronauer Molecular biology of prostate cancer Mol. Hum. Reprod., August 1, 2003; 9(8): 437 - 448. [Abstract] [Full Text] [PDF] |
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D. H. Lee, Y. Yang, S. J. Lee, K.-Y. Kim, T. H. Koo, S. M. Shin, K. S. Song, Y. H. Lee, Y.-J. Kim, J. J. Lee, et al. Macrophage Inhibitory Cytokine-1 Induces the Invasiveness of Gastric Cancer Cells by Up-Regulating the Urokinase-type Plasminogen Activator System Cancer Res., August 1, 2003; 63(15): 4648 - 4655. [Abstract] [Full Text] [PDF] |
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S. Rossi, E. Graner, P. Febbo, L. Weinstein, N. Bhattacharya, T. Onody, G. Bubley, S. Balk, and M. Loda Fatty Acid Synthase Expression Defines Distinct Molecular Signatures in Prostate Cancer Mol. Cancer Res., August 1, 2003; 1(10): 707 - 715. [Abstract] [Full Text] [PDF] |
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M. Grzmil, P. Thelen, B. Hemmerlein, S. Schweyer, S. Voigt, D. Mury, and P. Burfeind Bax Inhibitor-1 Is Overexpressed in Prostate Cancer and Its Specific Down-Regulation by RNA Interference Leads to Cell Death in Human Prostate Carcinoma Cells Am. J. Pathol., August 1, 2003; 163(2): 543 - 552. [Abstract] [Full Text] [PDF] |
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D. K. Vanaja, J. C. Cheville, S. J. Iturria, and C. Y. F. Young Transcriptional Silencing of Zinc Finger Protein 185 Identified by Expression Profiling Is Associated with Prostate Cancer Progression Cancer Res., July 15, 2003; 63(14): 3877 - 3882. [Abstract] [Full Text] [PDF] |
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K. A. Iczkowski and C. G. Pantazis Overexpression of NSAID-Activated Gene Product in Prostate Cancer International Journal of Surgical Pathology, July 1, 2003; 11(3): 159 - 166. [Abstract] [PDF] |
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D. A. Brown, R. L. Ward, P. Buckhaults, T. Liu, K. E. Romans, N. J. Hawkins, A. R. Bauskin, K. W. Kinzler, B. Vogelstein, and S. N. Breit MIC-1 Serum Level and Genotype: Associations with Progress and Prognosis of Colorectal Carcinoma Clin. Cancer Res., July 1, 2003; 9(7): 2642 - 2650. [Abstract] [Full Text] [PDF] |
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G. L. Shen-Ong, Y. Feng, and D. A. Troyer Expression Profiling Identifies a Novel {alpha}-Methylacyl-CoA Racemase Exon with Fumarate Hydratase Homology Cancer Res., June 15, 2003; 63(12): 3296 - 3301. [Abstract] [Full Text] [PDF] |
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D. R. Rhodes, M. G. Sanda, A. P. Otte, A. M. Chinnaiyan, and M. A. Rubin Multiplex Biomarker Approach for Determining Risk of Prostate-Specific Antigen-Defined Recurrence of Prostate Cancer J Natl Cancer Inst, May 7, 2003; 95(9): 661 - 668. [Abstract] [Full Text] [PDF] |
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S. Singh, S. Sadacharan, S. Su, A. Belldegrun, S. Persad, and G. Singh Overexpression of Vimentin: Role in the Invasive Phenotype in an Androgen-independent Model of Prostate Cancer Cancer Res., May 1, 2003; 63(9): 2306 - 2311. [Abstract] [Full Text] [PDF] |
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G. J. Gordon, R. V. Jensen, L.-L. Hsiao, S. R. Gullans, J. E. Blumenstock, W. G. Richards, M. T. Jaklitsch, D. J. Sugarbaker, and R. Bueno Using Gene Expression Ratios to Predict Outcome Among Patients With Mesothelioma J Natl Cancer Inst, April 16, 2003; 95(8): 598 - 605. [Abstract] [Full Text] [PDF] |
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J. B. Welsh, L. M. Sapinoso, S. G. Kern, D. A. Brown, T. Liu, A. R. Bauskin, R. L. Ward, N. J. Hawkins, D. I. Quinn, P. J. Russell, et al. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum PNAS, March 18, 2003; 100(6): 3410 - 3415. [Abstract] [Full Text] [PDF] |
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A. Santamaria, P. L. Fernandez, X. Farre, P. Benedit, J. Reventos, J. Morote, R. Paciucci, and T. M. Thomson PTOV-1, a Novel Protein Overexpressed in Prostate Cancer, Shuttles between the Cytoplasm and the Nucleus and Promotes Entry into the S Phase of the Cell Division Cycle Am. J. Pathol., March 1, 2003; 162(3): 897 - 905. [Abstract] [Full Text] [PDF] |
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P. Philip-Couderc, F. Smih, M. Pelat, C. Vidal, P. Verwaerde, A. Pathak, S. Buys, M. Galinier, J.-M. Senard, and P. Rouet Cardiac Transcriptome Analysis in Obesity-Related Hypertension Hypertension, March 1, 2003; 41(3): 414 - 421. [Abstract] [Full Text] [PDF] |
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V.-M. Wasenius, S. Hemmer, E. Kettunen, S. Knuutila, K. Franssila, and H. Joensuu Hepatocyte Growth Factor Receptor, Matrix Metalloproteinase-11, Tissue Inhibitor of Metalloproteinase-1, and Fibronectin Are Up-Regulated in Papillary Thyroid Carcinoma: A cDNA and Tissue Microarray Study Clin. Cancer Res., January 1, 2003; 9(1): 68 - 75. [Abstract] [Full Text] [PDF] |
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W. Xin, D. R. Rhodes, C. Ingold, A. M. Chinnaiyan, and M. A. Rubin Dysregulation of the Annexin Family Protein Family Is Associated with Prostate Cancer Progression Am. J. Pathol., January 1, 2003; 162(1): 255 - 261. [Abstract] [Full Text] [PDF] |
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A. Bar-Shira, J. H. Pinthus, U. Rozovsky, M. Goldstein, W. R. Sellers, Y. Yaron, Z. Eshhar, and A. Orr-Urtreger Multiple Genes in Human 20q13 Chromosomal Region Are Involved in an Advanced Prostate Cancer Xenograft Cancer Res., December 1, 2002; 62(23): 6803 - 6807. [Abstract] [Full Text] [PDF] |
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V. Srikantan, M. Valladares, J. S. Rhim, J. W. Moul, and S. Srivastava HEPSIN Inhibits Cell Growth/Invasion in Prostate Cancer Cells Cancer Res., December 1, 2002; 62(23): 6812 - 6816. [Abstract] [Full Text] [PDF] |
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J. J. Gildea, M. J. Seraj, G. Oxford, M. A. Harding, G. M. Hampton, C. A. Moskaluk, H. F. Frierson, M. R. Conaway, and D. Theodorescu RhoGDI2 Is an Invasion and Metastasis Suppressor Gene in Human Cancer Cancer Res., November 15, 2002; 62(22): 6418 - 6423. [Abstract] [Full Text] [PDF] |
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A. Dash, I. P. Maine, S. Varambally, R. Shen, A. M. Chinnaiyan, and M. A. Rubin Changes in Differential Gene Expression because of Warm Ischemia Time of Radical Prostatectomy Specimens Am. J. Pathol., November 1, 2002; 161(5): 1743 - 1748. [Abstract] [Full Text] [PDF] |
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H. F. Frierson Jr, A. K. El-Naggar, J. B. Welsh, L. M. Sapinoso, A. I. Su, J. Cheng, T. Saku, C. A. Moskaluk, and G. M. Hampton Large Scale Molecular Analysis Identifies Genes with Altered Expression in Salivary Adenoid Cystic Carcinoma Am. J. Pathol., October 1, 2002; 161(4): 1315 - 1323. [Abstract] [Full Text] [PDF] |
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G. Velasco, S. Cal, V. Quesada, L. M. Sanchez, and C. Lopez-Otin Matriptase-2, a Membrane-bound Mosaic Serine Proteinase Predominantly Expressed in Human Liver and Showing Degrading Activity against Extracellular Matrix Proteins J. Biol. Chem., September 27, 2002; 277(40): 37637 - 37646. [Abstract] [Full Text] [PDF] |
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R. Kuefer, S. Varambally, M. Zhou, P. C. Lucas, M. Loeffler, H. Wolter, T. Mattfeldt, R. E. Hautmann, J. E. Gschwend, T. R. Barrette, et al. {alpha}-Methylacyl-CoA Racemase: Expression Levels of this Novel Cancer Biomarker Depend on Tumor Differentiation Am. J. Pathol., September 1, 2002; 161(3): 841 - 848. [Abstract] [Full Text] [PDF] |
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N. Winssinger, S. Ficarro, P. G. Schultz, and J. L. Harris Profiling protein function with small molecule microarrays PNAS, August 20, 2002; 99(17): 11139 - 11144. [Abstract] [Full Text] [PDF] |
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D. R. Rhodes, T. R. Barrette, M. A. Rubin, D. Ghosh, and A. M. Chinnaiyan Meta-Analysis of Microarrays: Interstudy Validation of Gene Expression Profiles Reveals Pathway Dysregulation in Prostate Cancer Cancer Res., August 1, 2002; 62(15): 4427 - 4433. [Abstract] [Full Text] [PDF] |
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G. W. Birrell, J. A. Brown, H. I. Wu, G. Giaever, A. M. Chu, R. W. Davis, and J. M. Brown Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents PNAS, June 25, 2002; 99(13): 8778 - 8783. [Abstract] [Full Text] [PDF] |
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D. Karan, D. L. Kelly, A. Rizzino, M.-F. Lin, and S. K. Batra Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells Carcinogenesis, June 1, 2002; 23(6): 967 - 976. [Abstract] [Full Text] [PDF] |
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