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[Cancer Research 61, 5974-5978, August 15, 2001]
© 2001 American Association for Cancer Research


Advances in Brief

Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer

John B. Welsh, Lisa M. Sapinoso, Andrew I. Su, Suzanne G. Kern, Jessica Wang-Rodriguez, Christopher A. Moskaluk, Henry F. Frierson, Jr. and Garret M. Hampton1

Genomics Institute of the Novartis Research Foundation, San Diego, California 92121 [J. B. W., L. M. S., S. G. K., G. M. H.]; The Scripps Research Institute, La Jolla, California 92037 [A. I. S.]; Department of Pathology, University of California, San Diego, La Jolla, California 92093 [J. W-R.]; and Department of Pathology, University of Virginia, Charlottesville, Virginia 22908 [C. A. M., H. F. F.]

Detection, treatment, and prediction of outcome for men with prostate cancer increasingly depend on a molecular understanding of tumor development and behavior. We characterized primary prostate cancer by monitoring expression levels of more than 8900 genes in normal and malignant tissues. Patterns of gene expression across tissues revealed a precise distinction between normal and tumor samples, and revealed a striking group of about 400 genes that were overexpressed in tumor tissues. We ranked these genes according to their differential expression in normal and cancer tissues by selecting for highly and specifically overexpressed genes in the majority of cancers with correspondingly low or absent expression in normal tissues. Several such genes were identified that act within a variety of biochemical pathways and encode secreted molecules with diagnostic potential, such as the secreted macrophage inhibitory cytokine, MIC-1. Other genes, such as fatty acid synthase, encode enzymes known as drug targets in other contexts, which suggests new therapeutic approaches.




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