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[Cancer Research 61, 5979-5984, August 15, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Estrogen Receptor Status in Breast Cancer Is Associated with Remarkably Distinct Gene Expression Patterns1

Sofia Gruvberger, Markus Ringnér, Yidong Chen, Sujatha Panavally, Lao H. Saal, Åke Borg, Mårten Fernö, Carsten Peterson and Paul S. Meltzer2

Department of Oncology [S. G., Å. B., M. F.] and Complex Systems Division, Department of Theoretical Physics [M. R., C. P.], Lund University, SE-221 00 Lund, Sweden, and Cancer Genetics Branch, National Human Genome Research Institute [S. G., M. R., Y. C., S. P., L. H. S., P. S. M.], NIH, Bethesda, Maryland 20892

To investigate the phenotype associated with estrogen receptor {alpha} (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. Using artificial neural networks as well as standard hierarchical clustering techniques, the tumors could be classified according to ER status, and a list of genes which discriminate tumors according to ER status was generated. The artificial neural networks could accurately predict ER status even when excluding top discriminator genes, including ER itself. By reference to the serial analysis of gene expression database, we found that only a small proportion of the 100 most important ER discriminator genes were also regulated by estradiol in MCF-7 cells. The results provide evidence that ER+ and ER- tumors display remarkably different gene-expression phenotypes not solely explained by differences in estrogen responsiveness.




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M Lacroix, R-A Toillon, and G Leclercq
Stable 'portrait' of breast tumors during progression: data from biology, pathology and genetics
Endocr. Relat. Cancer, September 1, 2004; 11(3): 497 - 522.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
K. Yu, C. H. Lee, P. H. Tan, and P. Tan
Conservation of Breast Cancer Molecular Subtypes and Transcriptional Patterns of Tumor Progression Across Distinct Ethnic Populations
Clin. Cancer Res., August 15, 2004; 10(16): 5508 - 5517.
[Abstract] [Full Text] [PDF]

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 JNCI J Natl Cancer InstHome page
W. D. Foulkes
Re: Estrogen Receptor Status of Primary Breast Cancer Is Predictive of Estrogen Receptor Status of Contralateral Breast Cancer
J Natl Cancer Inst, July 7, 2004; 96(13): 1040 - 1041.
[Full Text] [PDF]

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 Genome ResHome page
H. K. Lee, A. K. Hsu, J. Sajdak, J. Qin, and P. Pavlidis
Coexpression Analysis of Human Genes Across Many Microarray Data Sets
Genome Res., June 1, 2004; 14(6): 1085 - 1094.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
M. A. Rubin, S. Varambally, R. Beroukhim, S. A. Tomlins, D. R. Rhodes, P. L. Paris, M. D. Hofer, M. Storz-Schweizer, R. Kuefer, J. A. Fletcher, et al.
Overexpression, Amplification, and Androgen Regulation of TPD52 in Prostate Cancer
Cancer Res., June 1, 2004; 64(11): 3814 - 3822.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
V. Bourdeau, J. Deschenes, R. Metivier, Y. Nagai, D. Nguyen, N. Bretschneider, F. Gannon, J. H. White, and S. Mader
Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse
Mol. Endocrinol., June 1, 2004; 18(6): 1411 - 1427.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
K. Yu, C. H. Lee, P. H. Tan, G. S. Hong, S. B. Wee, C. Y. Wong, and P. Tan
A Molecular Signature of the Nottingham Prognostic Index in Breast Cancer
Cancer Res., May 1, 2004; 64(9): 2962 - 2968.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
G. V. Glinsky, T. Higashiyama, and A. B. Glinskii
Classification of Human Breast Cancer Using Gene Expression Profiling as a Component of the Survival Predictor Algorithm
Clin. Cancer Res., April 1, 2004; 10(7): 2272 - 2283.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
F. M. Selaru, J. Yin, A. Olaru, Y. Mori, Y. Xu, S. H. Epstein, F. Sato, E. Deacu, S. Wang, A. Sterian, et al.
An Unsupervised Approach to Identify Molecular Phenotypic Components Influencing Breast Cancer Features
Cancer Res., March 1, 2004; 64(5): 1584 - 1588.
[Abstract] [Full Text] [PDF]

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 JCOHome page
P. N. Span, E. Waanders, P. Manders, J. J.T.M. Heuvel, J. A. Foekens, M. A. Watson, L. V.A.M. Beex, and F. C.G.J. Sweep
Mammaglobin Is Associated With Low-Grade, Steroid Receptor-Positive Breast Tumors From Postmenopausal Patients, and Has Independent Prognostic Value for Relapse-Free Survival Time
J. Clin. Oncol., February 15, 2004; 22(4): 691 - 698.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. Frasor, F. Stossi, J. M. Danes, B. Komm, C. R. Lyttle, and B. S. Katzenellenbogen
Selective Estrogen Receptor Modulators: Discrimination of Agonistic versus Antagonistic Activities by Gene Expression Profiling in Breast Cancer Cells
Cancer Res., February 15, 2004; 64(4): 1522 - 1533.
[Abstract] [Full Text] [PDF]

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 Molecular Cancer TherapeuticsHome page
S. K. Gruvberger-Saal, P. Eden, M. Ringner, B. Baldetorp, G. Chebil, A. Borg, M. Ferno, C. Peterson, and P. S. Meltzer
Predicting continuous values of prognostic markers in breast cancer from microarray gene expression profiles
Mol. Cancer Ther., February 1, 2004; 3(2): 161 - 168.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. ProteomicsHome page
M. Huber, I. Bahr, J. R. Kratzschmar, A. Becker, E.-C. Muller, P. Donner, H.-D. Pohlenz, M. R. Schneider, and A. Sommer
Comparison of Proteomic and Genomic Analyses of the Human Breast Cancer Cell Line T47D and the Antiestrogen-resistant Derivative T47D-r
Mol. Cell. Proteomics, January 1, 2004; 3(1): 43 - 55.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
B. Weigelt, A. M. Glas, L. F. A. Wessels, A. T. Witteveen, J. L. Peterse, and L. J. van't Veer
Gene expression profiles of primary breast tumors maintained in distant metastases
PNAS, December 23, 2003; 100(26): 15901 - 15905.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
Y. Kun, L. C. How, T. P. Hoon, V. B. Bajic, T. S. Lam, A. Aggarwal, H. G. Sze, W. S. Bok, W. C. Yin, and P. Tan
Classifying the estrogen receptor status of breast cancers by expression profiles reveals a poor prognosis subpopulation exhibiting high expression of the ERBB2 receptor
Hum. Mol. Genet., December 15, 2003; 12(24): 3245 - 3258.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
H. E. Cunliffe, M. Ringner, S. Bilke, R. L. Walker, J. M. Cheung, Y. Chen, and P. S. Meltzer
The Gene Expression Response of Breast Cancer to Growth Regulators: Patterns and Correlation with Tumor Expression Profiles
Cancer Res., November 1, 2003; 63(21): 7158 - 7166.
[Abstract] [Full Text] [PDF]

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 JNCI J Natl Cancer InstHome page
W. D. Foulkes, I. M. Stefansson, P. O. Chappuis, L. R. Begin, J. R. Goffin, N. Wong, M. Trudel, and L. A. Akslen
Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer
J Natl Cancer Inst, October 1, 2003; 95(19): 1482 - 1485.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
J. Frasor, J. M. Danes, B. Komm, K. C. N. Chang, C. R. Lyttle, and B. S. Katzenellenbogen
Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype
Endocrinology, October 1, 2003; 144(10): 4562 - 4574.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. G. Kleer, Q. Cao, S. Varambally, R. Shen, I. Ota, S. A. Tomlins, D. Ghosh, R. G. A. B. Sewalt, A. P. Otte, D. F. Hayes, et al.
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
PNAS, September 30, 2003; 100(20): 11606 - 11611.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. Sotiriou, S.-Y. Neo, L. M. McShane, E. L. Korn, P. M. Long, A. Jazaeri, P. Martiat, S. B. Fox, A. L. Harris, and E. T. Liu
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
PNAS, September 2, 2003; 100(18): 10393 - 10398.
[Abstract] [Full Text] [PDF]

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 GeneticsHome page
M. Perez-Enciso, M. A. Toro, M. Tenenhaus, and D. Gianola
Combining Gene Expression and Molecular Marker Information for Mapping Complex Trait Genes: A Simulation Study
Genetics, August 1, 2003; 164(4): 1597 - 1606.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S. M. Henshall, D. E. H. Afar, J. Hiller, L. G. Horvath, D. I. Quinn, K. K. Rasiah, K. Gish, D. Willhite, J. G. Kench, M. Gardiner-Garden, et al.
Survival Analysis of Genome-Wide Gene Expression Profiles of Prostate Cancers Identifies New Prognostic Targets of Disease Relapse
Cancer Res., July 15, 2003; 63(14): 4196 - 4203.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
T. Sorlie, R. Tibshirani, J. Parker, T. Hastie, J. S. Marron, A. Nobel, S. Deng, H. Johnsen, R. Pesich, S. Geisler, et al.
Repeated observation of breast tumor subtypes in independent gene expression data sets
PNAS, July 8, 2003; 100(14): 8418 - 8423.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
L. Pusztai, M. Ayers, J. Stec, E. Clark, K. Hess, D. Stivers, A. Damokosh, N. Sneige, T. A. Buchholz, F. J. Esteva, et al.
Gene Expression Profiles Obtained from Fine-Needle Aspirations of Breast Cancer Reliably Identify Routine Prognostic Markers and Reveal Large-Scale Molecular Differences between Estrogen-negative and Estrogen-positive Tumors
Clin. Cancer Res., July 1, 2003; 9(7): 2406 - 2415.
[Abstract] [Full Text] [PDF]

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 The OncologistHome page
L. Pusztai, M. Ayers, J. Stec, and G. N. Hortobagyi
Clinical Application of cDNA Microarrays in Oncology
Oncologist, June 1, 2003; 8(3): 252 - 258.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
M. Phelps, M. Darley, J. N. Primrose, and J. P. Blaydes
p53-independent Activation of the hdm2-P2 Promoter through Multiple Transcription Factor Response Elements Results in Elevated hdm2 Expression in Estrogen Receptor {alpha}-positive Breast Cancer Cells
Cancer Res., May 15, 2003; 63(10): 2616 - 2623.
[Abstract] [Full Text] [PDF]

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 JCOHome page
M. J. Piccart-Gebhart
Mathematics and Oncology: A Match for Life?
J. Clin. Oncol., April 15, 2003; 21(8): 1425 - 1428.
[Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
I. Hedenfalk, M. Ringner, A. Ben-Dor, Z. Yakhini, Y. Chen, G. Chebil, R. Ach, N. Loman, H. Olsson, P. Meltzer, et al.
Molecular classification of familial non-BRCA1/BRCA2 breast cancer
PNAS, March 4, 2003; 100(5): 2532 - 2537.
[Abstract] [Full Text] [PDF]

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 JCOHome page
H. T. Lynch, C. L. Snyder, J. F. Lynch, B. D. Riley, and W. S. Rubinstein
Hereditary Breast-Ovarian Cancer at the Bedside: Role of the Medical Oncologist
J. Clin. Oncol., February 15, 2003; 21(4): 740 - 753.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. Palmieri, S. Poggi, V. Ulivi, G. Casartelli, and P. Manduca
Pro-collagen I COOH-terminal Trimer Induces Directional Migration and Metalloproteinases in Breast Cancer Cells
J. Biol. Chem., January 31, 2003; 278(6): 3639 - 3647.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
M. J. van de Vijver, Y. D. He, L. J. van 't Veer, H. Dai, A. A.M. Hart, D. W. Voskuil, G. J. Schreiber, J. L. Peterse, C. Roberts, M. J. Marton, et al.
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
N. Engl. J. Med., December 19, 2002; 347(25): 1999 - 2009.
[Abstract] [Full Text] [PDF]

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 NEJMHome page
A. Kallioniemi
Molecular Signatures of Breast Cancer -- Predicting the Future
N. Engl. J. Med., December 19, 2002; 347(25): 2067 - 2068.
[Full Text] [PDF]

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 Cancer Res.Home page
J. L. Dennis, J. K. Vass, E. C. Wit, W. N. Keith, and K. A. Oien
Identification from Public Data of Molecular Markers of Adenocarcinoma Characteristic of the Site of Origin
Cancer Res., November 1, 2002; 62(21): 5999 - 6005.
[Abstract] [Full Text] [PDF]

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 JNCI J Natl Cancer InstHome page
I. A. Hedenfalk
Gene Expression Profiling of Hereditary and Sporadic Ovarian Cancers Reveals Unique BRCA1 and BRCA2 Signatures
J Natl Cancer Inst, July 3, 2002; 94(13): 960 - 961.
[Full Text] [PDF]

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 EndocrinologyHome page
D. Soulet and S. Rivest
Perspective: How to Make Microarray, Serial Analysis of Gene Expression, and Proteomic Relevant to Day-to-Day Endocrine Problems and Physiological Systems
Endocrinology, June 1, 2002; 143(6): 1995 - 2001.
[Abstract] [Full Text] [PDF]


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