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[Cancer Research 61, 6328-6330, September 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Enhanced Adenovirus Transgene Expression in Malignant Cells Treated with the Histone Deacetylase Inhibitor FR901228

Masaki Kitazono, Merrill E. Goldsmith, Takashi Aikou, Susan Bates and Tito Fojo1

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 [M. K., M. E. G., S. B., T. F.], and First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan [T. A.]

The presence of coxsackie and adenovirus receptor (CAR) and {alpha}v integrin on cell surfaces is required for efficient adenovirus infection. Treatment of cells with the histone deacetylase inhibitor FR901228 (depsipeptide) increased CAR and {alpha}v integrin RNA levels in six cancer cell lines. Sodium butyrate and trichostatin A, other histone deacetylase inhibitors, caused similar increases. Cells treated with FR901228 prior to infection had a 4–10-fold increase in transgene expression from a ß-galactosidase-expressing adenoviral vector. These studies suggest that FR901228 increases the efficiency of adenoviral transgene expression and may be useful in cancer gene therapy.




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Copyright © 2001 by the American Association for Cancer Research.