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[Cancer Research 61, 6331-6334, September 1, 2001]
© 2001 American Association for Cancer Research

Advances in Brief

Loss of Annexin II Heavy and Light Chains in Prostate Cancer and Its Precursors1

Albert Chetcuti, Sienna H. Margan, Peter Russell, Stephen Mann, Douglas S. Millar, Susan J. Clark, John Rogers, David J. Handelsman and Qihan Dong2

Department of Medicine, the University of Sydney, NSW 2006 [A. C., S. H. M., Q. D.]; Departments of Anatomical Pathology [P. R.] and Urology [J. R.] and Kanematsu Laboratories [D. S. M., S. J. C.], Royal Prince Alfred Hospital, NSW 2050; and ANZAC Research Institute and Departments of Andrology [D. J. H.] and Anatomical Pathology [S. M.], Concord Repatriation General Hospital, NSW 2139, Australia

Annexin II mRNA coding for a calcium binding protein was found to be absent in prostate cancer by subtractive hybridization and Northern analysis. In contrast to high expression in normal and benign hyperplastic glandular and basal epithelium, Annexin II heavy (p36) and light (p11) chains in 31/31 prostate cancer specimens were lost immunohistochemically. In glands involved by prostate intraepithelial neoplasia, 65% lost both chains in glandular epithelial cells, whereas basal cells were all positively stained. Southern analysis of cancer DNA showed no noticeable deletion in p36 gene. LNCaP cells treated with 5-azacytidine re-expressed p36, suggesting methylation could be responsible for the silencing.




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Copyright © 2001 by the American Association for Cancer Research.